戊型病毒性肝炎患者血清可溶性白细胞介素-2受体变化的研究

张缭云; 李德华; 张玲荣; 王守义

戊型病毒性肝炎患者血清可溶性白细胞介素-2受体变化的研究

详细信息

中图分类号: R512.65
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出版历程
- 出版日期: 2001-02-20

The study of the level of serum soluble interleukin 2 receptor in patients with viral hepatitis E.

摘要

摘要: 探讨血清可溶性白细胞介素 - 2受体（SIL - 2R）与戊型肝炎肝细胞损害和病期的关系。采用双抗夹心法对 18例戊型肝炎患者急性期、恢复期血清进行SIL - 2R测定。急性期SIL - 2R与恢复期比较 ,差别有显著性（P <0 0 5 ） ,恢复期与正常对照组比较差别无显著性（P >0 0 5 ） ;相关分析表明 ,急性期SIL - 2R与ALT存在正相关 ,(r =0 85 7,t=6 7788,（P <0 0 5 ） ,而与Bil虽也存在正相关 ,但差别无显著性 (r =0 10 5 7,t=0 42 5 2 ,（P >0 0 5 ）。戊型病毒性肝炎时 ,肝功能的损害与免疫参与有关 ,测定血清SIL - 2R可作为对戊型肝炎病情预测的一项指标。
- 病毒性肝炎 /
- 可溶性白细胞介素2受体 /
- 戊型肝炎病毒
Abstract: To study the relation between the level of serum interleoukin-2 receptor (SIL-2R) and the damage of heptocyte in viral hepatitis E (HE) .The level of SIL-2R in acute phase is higher than that in recovery phase ( (P<0.05) , No signi-fi cant difference existed between recovery phase and normal controt (P<0.05) .The level of SIL-2R in acute phase is correlated with the level of ALT positively (r=0.857, t=6.7788, P<0.05) , but there is no relation between the levels of SIL-2R and Bil (r=0.1057, t=0.4252, (P>0.05) .The damage of hepatocyte in HE is related to immume.The level of SIL-2R in HE is a predictable index for severity of HE.
- Viral hepatitis /
- Serum interleukin 2 receptor /
- Hepatitis E viral

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参考文献(4)

[1] LoughnanMS , SandersonCJ , NossalGJ Solubleinterleukin 2receptorsarereleasedfromthecellsurfadeofnormalmuringBlymphocytes stimulatedwithinterleukin 5 [J] ProcNatiAcadSCIUSA , 1988, 85 (9) ∶3115

[2]GreenWC , LeonardWJ, DepperJM , etal Thehumaninterleukin2receptor∶normalandabnormalexpresioninTcellsandinleukemiasinducedbythenumanT lymphotropicretroviruses[J] AnninternalMed , 1986 , 10 5∶5 0 6

[3]朱瑞龙 , 沈健伟血清可溶性白细胞介素 2受体测定在病毒性肝炎中的意义 [J] 中华传染病杂志 , 1995 , 9 (3) ∶2 84

[4]郝春秋 , 阎荣甲肝患者淋巴细胞的表达及血清释放的动态变化[J] 中华传染病杂志 , 1994, 12 , (2 ) ∶89

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