血清前S1抗原与HBV其它标志物及其DNA检测间的关系

阮秀花; 张效本; 卢洁; 张喜梅

血清前S1抗原与HBV其它标志物及其DNA检测间的关系

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中图分类号: R446.6;R446.5
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出版历程
- 出版日期: 2005-01-20

Relationship between Pre-S1 antigen and other HBV markers, HBVDNA.

摘要

摘要: 探讨血清乙型肝炎病毒前S1抗原（PreS1）与HBV其它标志物及其DNA检测间的关系。对 916例血清标本进行PreS1、乙肝病毒标志物和HBVDNA同步检测。在HBsAg（+）病例组 ,PreS1与HBeAg及HBVDNA阳性率分别为 77 0 9%、5 9 78%和 6 5 36 % ,结果符合率达 72 6 3%和 74 72 % ,在正常对照组三者均为阴性 ;在HBsAg、HBeAg、抗HBc与HBsAg、抗HBe、抗HBc和HBsAg、抗HBc三种阳性模式组 ,PreS1与HBVDNA结果符合率为90 4 2 %、5 1 0 0 %和 5 3 4 1% ,PreS1阳性率（91 5 9%、5 5 0 0 %、5 6 82 % ）与HBVDNA（96 96 %、17 0 0 %、2 1 5 9% ）相比 ,差异有显著性（P均 <0 0 5 ）。提示血清PreS1主要存在于HBsAg携带者 ,且与HBeAg和HBVDNA关系密切 ,是反映HBV复制及传染性的又一可靠血清学指标。PreS1联合HBV标志物同步检测具有重要的临床意义
- 前S1抗原 /
- 乙肝病毒标志物 /
- HBVDNA
Abstract: To explore the relationship between Pre-S1 antigen (PreS1) and other hepatitis B virus (HBV) markers, HBV DNA.Pre-S1 antigen, HBV markers (HBVM) and HBV DNA in 916 serum samples were synchronously detected.The positive rates of Pre-S1 antigen, HBeAg and HBV DNA in the patient group are 77.09%, 59.78%, 65.36% respectively. The coincident rates of results are 72.63%, 74.72%, while they are all negative in control group. Among the three positive patterns with HBsAg, HBeAg, Anti-HBc or HBsAg, Anti-HBe, Anti-HBc and HBsAg, Anti-HBc, the coincident rate of Pre-S1 and HBV DNA were 90.42%、51.00%、and 53.41%.Compared the positive rates of Pre-S1 (91.59%、55.00%、56.82%) and those of HBV DNA (96.96%、17.00%、21.59%) , the differences were significant (all P<0.05) .The results suggested that Pre-S1 mainly exists in patients with HBsAg (+) , and has close relation with the condition of HBeAg and HBV DNA.So it is another dependable index to reflect the HBV replication and infective activity, the synchronous detection of Pre-S1 with HBV markers has its important clinical meaning.
- Pre-S1 antigen /
- HBV markers /
- HBV DNA.

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参考文献(4)

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[2] GerkenG , PaterliniP , MannsM , etal.AssayofhepatitisBVirus.DNAbyPolymeraseChainreactionanditsrelationshiptoPre-SandS -encodedViralSurfaceantigen[J].Hepatology, 1991, 13 (1) ∶158-66.

[3]崔杰峰, 潘柏中, 贾哲甫, 等.乙肝病毒PreS1与HBVM和HBVD NA检测的相关性分析[J].中国实验诊断学, 2002, 6 (3) ∶140～141.

[4] YuKiN , HayashinN , KatayamaK , etal.QuantitativeanalysisofPre-S1 andPS2 inrelationtoHBsAgexpression[J].Hepatology, 1990, 11 (1) ∶38-43.

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