PDF下载 ( 130 KB)
The study of A561C polymorpnisms of E-selectin in the chronic hepatitis B
-
摘要: 为明确E-选择素（E-selectin）A561C基因多态性与慢性乙型肝炎（CHB）的关系,采用PCR-RFLP技术对91名慢性乙型肝炎患者进行检测。结果显示E-selectin A561C基因存在AA、AC和CC三型,且与慢性乙型肝炎相关（P<0.05）,AC+CC基因型的患病风险是AA型的2.89倍,其血清sE-selectin水平显著高于AA型（P<0.01）,但肝功能指标差异不显著（P>0.05）。提示E-selectin A561C多态性与慢性乙型肝炎的感染有关,C等位基因可能是慢性乙型肝炎发病的易感因素之一。该位点多态性可影响血清E-selectin水平,但对肝功能损伤不起直接的作用。Abstract: To study the correlation of E-selectin A561C polymorphisms and chronic hepatitis B, E-selectin A561C polymorphisms were detected by PCR-RFLP in 91 (CHB) patients.Three genotypes (AA, AC and CC) were found which were an association with chronic hepatitis B (P<0.05) .The relative risk of suffering from chronic hepatitis B of genotype AC+CC was 2.89 times of the AA genptypes.Meanwhile serum sE-selectin level was sighificant higher than that of AA caniers markedly (P<0.01) .However the markers of liver injury didn't show significant difference (P>0.05) .Therefore there is an association between E-selectin A561C polymorphisms and chronic hepatitis B infection.Allele C may be one of predisposing factors chronic hepatitis B, its polymorphism has an effect on serum E-selectin level, but not on liver injury directly.
-
Key words:
- chronic hepatitis B /
- E-selectin /
- gene polymorphisms
-
[1]CervelloM, V irruso L, L ipan i G, et al.Serum concentration of E-selectin in patients w ith chron ic hepatitis, liver cirrhosis and hepato-cellu lar[J].Carcinoma, 2000, 26 (6) ∶345-351. [2]韦叶生, 李艳, 张平安.湖北地区汉族人群E-选择素表皮生长样区A561C基因多态性的研究[J].检验医学, 2004, 19 (1) ∶18-20. [3]中华医学会.病毒性肝炎防治方案[J].中华传染病杂志, 2001, 19 (1) ∶56-62. [4] Rauchhaus M, G ross M, Schu lz S, et al.The E-selectinSER128ARG gene polymorph ism and restenosis after Successfu l coro-nary angioplasty[J].Int Card iol, 2002, 83∶249-257. [5]闫明先, 刘倩, 王文奇, 等.可溶性E-选择素与慢性乙型肝炎的关系[J].中华传染病杂志, 2003, 21∶342-343. -
本文二维码
计量
- 文章访问数: 1893
- HTML全文浏览量: 16
- PDF下载量: 761
- 被引次数: 0
下载:
