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The relationship between serum NO and response to interferon α in patients with chronic hepatitis B
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摘要: 目的探讨一氧化氮（NO）在慢性乙肝疾病进展中的作用及NO与α-干扰素（IFN-α）疗效的关系。方法对采用IFN-α治疗的慢性乙肝患者40例,分别在治疗前、治疗12周和24周时检测血清NO浓度;治疗结束时,依据治疗效果分为应答组和无应答组,比较两组NO浓度变化。20例健康人做为对照组,对其血清NO浓度与慢性乙肝患者基线时血清NO浓度进行比较。结果慢性乙肝患者基线时血清NO水平显著高于健康对照组,其差异具有统计学意义（P<0.01）;慢性乙肝患者血清ALT水平和NO浓度呈正相关（r=0.673,P<0.001）;应答组患者血清NO浓度随治疗时间的延长而下降,治疗12周和24周时与治疗前比较差异均有统计学意义（P<0.01）,无应答组患者血清NO浓度在治疗过程中无明显变化。结论NO在慢性乙肝发病机制中可能起到重要作用,可作为IFN-α抗病毒疗效判断指标。Abstract: Objective To determine the effect of NO on the progression of CHB and the relationship between NO and efficacy of interferon α (INF α) .Methods 40 CHB patients treated with IFN α and 20 healthy controls were included in the study.Serum NO concentration was determined at base line, and 12 and 24 weeks after treatment.At the end of treatment, these patients were divided in to two groups according to the response to INF α.Results The serum NO concentration in CHB patients was significantly higher than that of the control group (p<0.01) .ALT level was positively correlated with serum NO concentration (r=0.673, p<0.001) .Among the patients responded to INF α, the NO concentration decreased gradually during the treatment.The NO concentration at 12 and 24 weeks were both significantly higher than the baseline (p<0.01) and had no significant change during IFN treatment in non responders (p>0.05) Conclusion NO may play an important role in the pathogenesis of CHB, and can be used as a predictor of treatment response.
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Key words:
- Chronic hepatitis B /
- nitric oxide /
- interferon α
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