Hedgehog信号通路与胰腺癌

谢学海; 郝昆; 杨尹默

Hedgehog信号通路与胰腺癌

北京大学第一医院外科

基金项目:

国家自然科学基金资助项目(30772120,30972897)；

详细信息

中图分类号: R735.9
计量
- 文章访问数: 4254
- HTML全文浏览量: 9
- PDF下载量: 930
- 被引次数: 0
出版历程
- 出版日期: 2010-05-20

Hedgehog signaling pathway and pancreatic cancer

Research funding:

摘要

摘要: <正>胰腺癌是预后最差的消化道恶性肿瘤,10余年来随分子生物学研究水平的提高及方法学的进步,对胰腺癌发生、发展过程中的机制研究日趋深入,在寻求新的早期诊断标志及丰富治疗途径方面,显现出深远影响。做为人类胚胎发育重要的调控因子——Hedgehog信号通路,在完成胰腺等器官正常
- 胰腺肿瘤 /
- 信号传导
- pancreatic neoplasms /
- signal transduction

HTML全文

参考文献(37)

[1]Pasca di Magliano M, Sekine S, Ermilov A, et al. Hedgehog/Ras interactions regulate early stages of pancreatic cancer[J]. Genes Dev, 2006, 20 (22) ∶3161-3173.

[2]Koga K, Nakamura M, Nakashima H, et al.Novel link between es-trogen receptor alpha and hedgehog pathway in breast cancer[J].Anticancer Res, 2008, 28 (2A) ∶731-740.

[3]Kasper M, Jaks V, Fiaschi M, et al. Hedgehog signalling in breast cancer[J]. Carcinogenesis, 2009, 30 (6) ∶903-911.

[4]Amano K, Ichida F, Sugita A, et al. MSX2 stimulates chondrocyte maturation by controlling Ihh expression[J]. J Biol Chem, 2008, 283 (43) ∶29513-29521.

[5]Zwerner JP, Joo J, Warner KL, et al. The EWS/FLI1 oncogenic transcription factor deregulates GLI1[J]. Oncogene, 2008, 27 (23) ∶3282-3291.

[6]Beauchamp E, Bulut G, Abaan O, et al.GLI1 is a direct tran-scriptional target of EWS-FLI1 oncoprotein[J].J Biol Chem, 2009, 284 (14) ∶9074-9082.

[7]Laner-Plamberger S, Kaser A, Paulischta M, et al. Cooperation between GLI and JUN enhances transcription of JUN and selected GLI target genes[J]. Oncogene, 2009, 28 (13) ∶1639-1651.

[8]Nolan-Stevaux O, Lau J, Truitt ML, et al.GLI1 is regulatedthrough Smoothened-independent mechanisms in neoplastic pan-creatic ducts and mediates PDAC cell survival andtransformation[J].Genes Dev, 2009, 23 (1) ∶24-36.

[9]Cai Q, Li J, Gao T, et al.Protein kinase Cdelta negatively regu-lates hedgehog signaling by inhibition of Gli1 activity[J].J BiolChem, 2009, 284 (4) ∶2150-2158.

[10]He J, Sheng T, Stelter AA, et al. Suppressing Wnt signaling by the hedgehog pathway through sFRP-1[J]. J Biol Chem, 2006, 81 (47) ∶ 35598-35602.

[11]Yanai K, Nakamura M, Akiyoshi T, et al. Crosstalk of hedgehog and Wnt pathways in gastric cancer[J]. Cancer Lett, 2008, 263 (1) ∶145-156.

[12]Kim JH, Shin HS, Lee SH, et al. Contrasting activity of Hedgehog and Wnt pathways according to gastric cancer cell differentiation: relevance of crosstalk mechanisms[J]. Cancer Sci, 2010, 101 (2) ∶328-335.

[13]Abe Y, Oda-Sato E, Tobiume K, et al.Hedgehog signaling over-rides p53-mediated tumor suppression by activating Mdm2[J].Proc Natl Acad Sci U S A, 2008, 105 (12) ∶4838-4843.

[14]Stecca B, Ruiz i Altaba A. A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers[J]. EMBO J, 2009, 28 (6) ∶663-676.

[15]Corcoran RB, Bachar Raveh T, Barakat MT, et al.Insulin-likegrowth factor 2 is required for progression to advanced medulloblas-toma in patched1 heterozygous mice[J].Cancer Res, 2008, 68 (21) ∶8788-8795.

[16]Parathath SR, Mainwaring LA, Fernandez-L A, et al.Insulin re-ceptor substrate 1 is an effector of sonic hedgehog mitogenic signa-ling in cerebellar neural precursors[J].Development, 2008, 135 (19) ∶3291-3300.

[17]Heo JS, Lee MY, Han HJ.Sonic hedgehog stimulates mouse em-bryonic stem cell proliferation by cooperation of Ca2+/protein ki-nase C and epidermal growth factor receptor as well as Gli1 activa-tion[J].Stem Cells, 2007, 25 (12) ∶3069-3080.

[18]Schnidar H, Eberl M, Klingler S, et al.Epidermal growth factorreceptor signaling synergizes with Hedgehog/GLI in oncogenic trans-formation via activation of the MEK/ERK/JUN pathway[J].Canc-er Res, 2009, 69 (4) ∶1284-1292.

[19]Yang Y, Tian X, Xie X, et al.Expression and regulation of hedge-hog signaling pathway in pancreatic cancer[J].Langenbecks ArchSurg, 2010, 395 (5) ∶515-525.

[20]Quint K, Stintzing S, Alinger B, et al.The expression pattern ofPDX-1, SHH, Patched and Gli-1 is associated with pathologicaland clinical features in human pancreatic cancer[J].Pancreatolo-gy, 2009, 9∶116-126.

[21]Thayer SP, di Magliano MP, Heiser PW, et al.Hedgehog is anearly and late mediator of pancreatic cancer tumorigenesis[J].Na-ture, 2003, 425 (6960) ∶851-856.

[22]Kayed H, Kleeff J, Keleg S, et al.Indian hedgehog signaling path-way:expression and regulation in pancreatic cancer[J].Int JCancer, 2004, 110 (5) ∶668-676.

[23]Park SW, Davison JM, Rhee J, et al. Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas[J]. Gastroenterology, 2008, 134 (7) ∶2080-2090.

[24]Yamazaki M, Nakamura K, Mizukami Y, et al.Sonic hedgehog de-rived from human pancreatic cancer cells augments angiogenic func-tion of endothelial progenitor cells[J].Cancer Sci, 2008, 99 (6) ∶1131-1138.

[25]Nakamura K, Sasajima J, Mizukami Y, et al. Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells[J]. PLoS One, 2010, 5 (1) ∶e8824.

[26]Nagai S, Nakamura M, Yanai K, et al.Gli1 contributes to the in-vasiveness of pancreatic cancer through matrix metalloproteinase-9activation[J].Cancer Sci, 2008, 99 (7) ∶1377-1384.

[27]Bailey JM, Swanson BJ, Hamada T, et al.Sonic hedgehog pro-motes desmoplasia in pancreatic cancer[J].Clin Cancer Res, 2008, 14 (19) ∶5995-6004.

[28]Katoh M. Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis[J]. Stem Cell Rev, 2007, 3 (1) ∶30-38.

[29]Yauch RL, Gould SE, Scales SJ, et al. A paracrine requirement for hedgehog signalling in cancer[J]. Nature, 2008, 455 (7211) ∶406-410.

[30]Nakashima H, Nakamura M, Yamaguchi H, et al.Nuclear factor-κB contributes to hedgehog signaling pathway activation through son-ic hedgehog induction in pancreatic cancer[J].Cancer Res, 2006, 66∶7041-7049.

[31]Bailey JM, Mohr AM, Hollingsworth MA. Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer[J]. Oncogene, 2009, 28 (40) ∶3513-3525.

[32]Feldmann G, Fendrich V, McGovern K, et al.An orally bioavail-able small-molecule inhibitor of Hedgehog signaling inhibits tumorinitiation and metastasis in pancreatic cancer[J].Mol Cancer Ther, 2008, 7 (9) ∶2725-2735.

[33]Zhao C, Chen A, Jamieson CH, et al.Hedgehog signalling is essen-tial for maintenance of cancer stem cells in myeloid leukaemia[J].Nature, 2009, 458 (7239) ∶776-779.

[34]Olive KP, Jacobetz MA, Davidson CJ, et al.Inhibition of Hedge-hog signaling enhances delivery of chemotherapy in a mouse modelof pancreatic cancer[J].Science, 2009, 324 (5933) ∶1457-1461.

[35]Shaw G, Prowse DM.Inhibition of andrgogen-independent pros-tate cancer cell growth is enhanced by combination therapy targetingHedgehog and ErbB signalling[J].Cancer Cell Int, 2008, 8∶3.

[36]Mimeault M, Johansson SL, Vankatraman G, et al.Combined tar-geting of epidermal growth factor receptor and hedgehog signaling bygefitinib and cyclopamine cooperatively improves the cytotoxiceffects of docetaxel on metastatic prostate cancer cells[J].MolCancer Ther, 2007, 6∶967-978.

[37]Hu WG, Liu T, Xiong JX, et al.Blockade of sonic hedgehog signalpathway enhances antiproliferative effect of EGFR inhibitor in pan-creatic cancer cells[J].Acta Pharmacol Sin, 2007, 28 (8) ∶1224-1230.

施引文献

资源附件(0)

访问统计