乙型肝炎病毒母婴传播阻断的共识与争议

陈巍; 丁洋; 盛秋菊; 窦晓光

乙型肝炎病毒母婴传播阻断的共识与争议

中国医科大学附属盛京医院感染科

基金项目:

国家自然科学基金项目(30972612)；辽宁省科学技术计划重大、重点项目(2009225010-7)；

详细信息

中图分类号: R512.62
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出版历程
- 收稿日期: 2011-07-22
- 出版日期: 2011-12-20

HBV mother-to-child transmission block-agreement and controversy

Research funding:

摘要

摘要: 慢性乙型肝炎因其严重的不良临床结局如肝硬化或肝细胞癌而成为严重的公共卫生问题,而母婴传播是导致慢性HBV感染的最主要原因。尽管HBV阳性孕妇所生的新生儿在出生后24 h之内应用了乙型肝炎疫苗和乙型肝炎免疫球蛋白(HBIG)进行联合免疫阻断,仍然有大约10%左右的新生儿感染了HBV,特别是高病毒载量的孕妇。本文将就HBV母婴传播的特点、目前在阻断措施方面达成的共识和存在的争议进行论述。
- 肝炎,乙型,慢性 /
- 肝炎病毒,乙型 /
- 疾病传播,垂直
Abstract: Hepatitis B virus (HBV) infection is one of the most severe public issue due to its serious harmful clinical outcomes such as cirrhosis or HCC.The mother-to-child transmission (MTCT, vertical transmission) is the main cause leading to chronic HBV infections.Though joint HBV immune prophylaxis with hepatitis B vaccine and hepatitis B immunoglobulin (HBIG) are given within 24hrs after birth for all neonates whose mothers are HBV positive, about 10% of them suffer from HBV infection in their early life, even in pregnant women with a high HBV DNA serum load.This paper discusses the thesis concerning on agreement and controversy regarding the MTCT.
- hepatitis B chronic /
- hepatitis B virus /
- disease transmission

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参考文献(9)

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