FibroScan技术在肝纤维化中的临床应用

王春妍; 陆伟

FibroScan技术在肝纤维化中的临床应用

王春妍,
陆伟

天津市第二人民医院

详细信息

中图分类号: R575.2
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出版历程
- 出版日期: 2013-03-20

Non-invasive diagnosis of liver fibrosis by FibroScan imaging

摘要

摘要:
肝纤维化是各种慢性肝病共同的病理表现。肝纤维化在早期乃至晚期都可以发生逆转。故预测及早期诊断肝脏纤维化对整个疾病的进程和治疗特别重要。肝活检仍是诊断肝纤维化的金标准,因有创性限制了其在临床上的广泛应用。目前,Fi-broScan作为一种无创性诊断方法成为研究热点,广泛应用于肝纤维化的诊断,此文就FibroScan临床应用进展作一综述。
- FibroScan /
- 肝硬化 /
- 诊断
Abstract:
Liver fibrosis is a common etiology of chronic liver diseases.Treatment in the early stage, by anti-inflammatories or other drugs targeting the specific fibrosis-promoting factor/pathogen, can reverse the liver fibrosis;treatments in the later stages can effectively reduce the extent of fibrosis.Therefore, sensitive and accurate methods to predict and/or diagnose liver fibrosis are crucial for identifying the condition at the earliest possible stage to initiate timely therapy and inhibit disease progression.Liver biopsy is currently the gold standard for diagnosing and staging fibrosis.However, the procedure is invasive and presents surgery-related risks, such as infection and bleeding.The FibroScan imaging system represents a new, non-invasive approach to diagnose and stage liver fibrosis.This review discusses the FibroScan technology and its clinical application and efficacy.
- FibroScan /
- liver cirrhosis /
- diagnosis

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参考文献(30)

[1]Manning DS, Afdhal NH.Diagnosis and quantitation of fibrosis[J].Gastroenterology, 2008, 134 (6) :1670-1681.

[2]Marcellin P, Ziol M, Bedossa P, et al.Non-invasive assessmentof liver fibrosis by stiffness measurement in patients with chronichepatitis B[J].Liver Int, 2009, 29 (2) :242-247.

[3]Osakabe K, Ichino N, Nishikawa T, et al.Reduction of liver stiff-ness by antiviral therapy in chronic hepatitis B[J].J Gastroenterol, 2011, 46 (11) :1324-1334.

[4]Zhang X, Lu W, Wang CY.Diagnostic value of fibroscan for liverfibrosis in patients with chronic hepatitis B[J].Tianjin Med J, 2011, 39 (3) :236-238. (in Chinese) 张旭, 陆伟, 王春妍.Fibroscan对慢性乙型肝炎肝脏纤维化的诊断价值[J].天津医药, 2011, 39 (3) :236-238.

[5]Ding H, Wu T, Ma K, et al, Noninvasive measurement of liver fibrosisby transient elastography and influencing factors in patients with chronichepatitis B-A single center retrospective study of 466 patients[J].JHuazhong Univ Sci Technolog Med Sci, 2012, 32 (1) :69-74.

[6]Maimone S, Calvaruso V, Pleguezuelo M, et al.An evaluation oftransient elastography in the discrimination of HBeAg-negative dis-ease from inactive hepatitis B carriers[J].J Viral Hepat, 2009, 16 (11) :769-774.

[7]Wong GL, Wong VW, Choi PC, et al.Clinical factors associatedwith liver stiffness in hepatitis B eantigen-positive chronic hepatitisB patients[J].Clin Gastroenterol Hepatol, 2009, 7 (2) :227-233.

[8]Chan HL, Wong GL, Tse CH, et al.Hepatitis B virus genotype Cis associated with more severe liver fibrosis than genotype B[J].Clin Gastroenterol Hepatol, 2009, 7 (12) :1361-1366.

[9]Zhang YG, Wang BE, Wang TL, et al.Assessment of hepatic fi-brosis by transient elastography in patients with chronic hepatitis B[J].Pathol Int, 2010, 60 (4) :284-290.

[10]Castera L, Foucher J, Bertet J, et al.Fibroscan and Fibrotest to assessliver fibrosis in HCV with normal aminotransferases[J].Hepatology, 2006, 43 (2) :373-374.

[11]Takemoto R, Nakamuta M, Aoyagi Y, et al.Validity of FibroScanvalues for predicting hepatic fibrosis stage in patients with chronicHCV infection[J].J Dig Dis, 2009, 10 (2) :145-148.

[12]Maor Y, Halfon P, Bashari D, et al.Fibrotest or Fibroscan for e-valuation of liver fibrosis in Haemophilia patients infected with hepa-titis C[J].Haemophilia, 2010, 16 (1) :148-154.

[13]Wang JH, Changchien CS, Hung CH, et al.Liver stiffness de-crease after effective antiviral therapy in patients with chronic hepa-titis C:Longitudinal study using FibroScan[J].J GastroenterolHepatol, 2010, 25 (5) :964-969.

[14]Wang QX, Shen L, Qiu DK, et al.Vafidation of transient elastography (Fibroscan) in assessment of hepatic fibrosis in autoimmone hepatitis[J].Chin J Hepatol, 2011, 19 (10) :782-784. (in Chinese) 王琦夏, 沈镭, 邱德凯, 等.肝脏瞬时弹性超声评价自身免疫性肝炎肝纤维化的价值[J].中华肝脏病杂志, 2011, 19 (10) :782-784.

[15]Nguyen-Khac E, Saint-Leger P, Tramier B, et al.Noninvasivediagnosis of large esophageal varices by Fibroscan:strong influenceof the cirrhosis etiology[J].Alcohol Clin Exp Res, 2010, 34 (7) :1146-1153.

[16]Chang HK, Park YJ, Koh H, et al.Hepatic Fibroscan for liver stiffnessscore measurement, a useful preendoscopic screening test for the de-tectlon of varlces in postoperative patients with biliary atresia[J].J Pe-diatr Gastroenterol Nutr, 2009, 49 (3) :323-328.

[17]Chen YP, Liang XE, Zhang Q, et al.Prediction of esophageal vari-ces in patients with hepatitis B related cirrhosis by liver stiffnessmeasurement[J].Infectious Disease Inf, 2010, 23 (30) :154-158. (in Chinese) 陈永鹏, 梁携儿, 张琪, 等.肝脏硬度检测对乙型肝炎肝硬化食管静脉曲张的预测[J].传染病信息, 2010, 23 (30) :154-158.

[18]Chen GF.Development and clinical application of transient elastogra-phy (FibroScan) [J].Med J Chin People's Liberation Army, 2011, 36 (11) :1131-1133. (in Chinese) 陈国风.瞬时弹性成像的研究进展及临床应用[J].解放军医学杂志, 2011, 36 (11) :1131-1133.

[19]Han P, Ji D, Zhang J, et al.Predictive value of FibroScan on liverascites cause by cirrhosis[J].Med J Chin People's Liberation Ar-my, 2011 (36) 11:1143-1144. (in Chinese) 韩萍, 纪冬, 张健, 等.瞬时弹性成像检测对肝硬化腹水的预测作用研究[J].解放军医学杂志, 2011, 36 (11) :1143-1144.

[20]Ghany MG, Doo E.Assessment of liver fibrosis:palpate, poke orpulse?[J].Hepatology, 2005, 42 (4) :759-761.

[21]Jung KS, Kim SU, Ahn SH, et al.Risk assessment of hepatitis Bvirus related hepatocellular carcinoma development using liver stiff-ness measuerment (fibroscan) [J].Hepatology, 2011, 53 (3) , 885-894.

[22]Masuzaki R, Tateishi R, Yoshida H, et al.Prospective risk assess-ment for hepatocellular carcinoma development in patients with chro-nic hepatitis C by transient elastography[J].Hepatology, 2009, 49 (6) :1954-1961.

[23]Masuzaki R, Tateishi R, Yoshida H, et al.Assessment of diseaseprogression in patients with transfusion-associated chronic hepatitisC using transient elastography[J].World J Gastroenterol, 2012, 18 (12) :1385-1390.

[24]Carrión JA, Torres F, Crespo G, et al.Liver stiffness idenifies twodifferent patterns of fibrosis progression in patients with hepatitis CVirus recurrence after liver transplantation[J].Hepatology, 2010, 51 (1) :23-34.

[25]Yoneda M, Yoneda M, Fujita K, et al.Transient elastography in pa-tients with non-alcoholic fatty liver disease (NAFLD) [J].Gut, 2007, 56 (9) :1330-1331.

[26]Janssens F, de Suray N, Piessevaux H, et al.Can transient elastographyreplace liver histology for determination of advanced fibrosis in alcoholicpatients:a real-life study[J].Clin Gastroenterol, 2010, 44 (8) :575-582.

[27]Wong VW, Vergniol J, Wong GL, et al.Diagnosis of fibrosis and cir-rhosis using liver stiffness measurement in nonalcoholic fatty liver dis-ease[J].Hepatology, 2010, 51 (2) :452-462.

[28]Topil'skaia NV, Morozov SV, Isakov VA, et al.Elastography effi-ciency in the liver fibrosis determination in patients with nonalcohol-ic fatty liver disease[J].Eksp Klin Gastroenterol, 2011, (6) :26-31.

[29]Roulot D, Costes JL, Buyck JF, et al.Transient elastography as ascreening tool for liver fibrosis and cirrhosis in a community-basedpopulation aged over 45 years[J].Gut, 2011, 60 (7) :977-984.

[30]Sini M, Sorbello O, Civolani A, et al.Non-invasive assessment ofhepatic fibrosis in a series of patients with Wilson's Disease[J].Dig Liver Dis, 2012, 44 (6) :487-491.

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