中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

肝细胞癌患者肝移植术后肿瘤复发转移的防治

季茹 窦科峰 许辉

引用本文:
Citation:

肝细胞癌患者肝移植术后肿瘤复发转移的防治

DOI: 10.3969/j.issn.1001-5256.2014.01.003
详细信息
  • 中图分类号: R735.7

Prevention and management of recurrence and metastasis of hepatocellular carcinoma after liver transplantation

  • 摘要: 肝细胞癌(HCC)仍是目前发病率较高的消化道肿瘤,肝移植能从根本上切除肿瘤病灶,是HCC综合治疗方案中的主要手段之一。移植后肿瘤的复发和转移问题,是影响受体长期生存的主要因素。近年来,得益于全球范围的技术改进和经验积累,在HCC的诊疗方面取得了的长足的发展和进步。针对HCC肝移植适应证、复发转移预测、肝移植围手术期干预和术后HCC复发的综合治疗等方面进行探讨。

     

  • [1] JEMAL A, BRAY F, CENTER MM, et al.Global cancer statistics[J].CA Cancer J Clin, 2011, 61 (2) :69-90.
    [2]Chinese Society of Liver Cancer, Chinese Anti-Cancer Association;Chinese Society of Clinical Oncology, Chinese Anti-Cancer Association;Liver Cancer Study Group, Chinese Society of Hepatology, Chinese Medical Association.Expert consensus on standardization of the management of primary liver cancer[J].J Clin Hepatol, 2009, 25 (2) :83-92. (in Chinese) 中国抗癌协会肝癌专业委员会;中国抗癌协会临床肿瘤学协作专业委员会;中华医学会肝病学分会肝癌学组.原发性肝癌规范化诊治的专家共识[J].临床肝胆病杂志, 2009, 25 (2) :83-92.
    [3]HOLLEBECQUE A, DECAENS T, BOLESLAWSKI E, et al.Natural history and therapeutic management of recurrent hepatocellular carcinoma after liver transplantation[J].Gastroenterol Clin Biol, 2009, 33 (5) :361-369.
    [4]PENG CH, CHEN H.Strategy for prevention and treatment of recurrent hepatocellular carcinoma after liver transplantation[J].Natl Med J China, 2011, 91 (22) :1513-1515. (in Chinese) 彭承宏, 陈皓.肝细胞癌肝移植术后复发的防治策略[J].中华医学杂志, 2011, 91 (22) :1513-1515.
    [5]SCHREIBMAN IR, BEJARANO P, MARTINEZ EJ, et al.Very late recurrence of hepatocellular carcinoma after liver transplantation:case report and literature review[J].Transplant Proc, 2006, 38 (9) :3140-3143.
    [6]ROAYAIE S, SCHWARTZ JD, SUNG MW, et al.Recurrence of hepatocellular carcinoma after liver transplant:patterns and prognosis[J].Liver Transpl, 2004, 10 (4) :534-540.
    [7]MELLOUL E, LESURTEL M, CARR BI, et al.Developments in liver transplantation for hepatocellular carcinoma[J].Semin Oncol, 2012, 39 (4) :510-521.
    [8]CHOK KS, CHAN SC, CHEUNG TT, et al.Late recurrence of hepatocellular carcinoma after liver transplantation[J].World J Surg, 2011, 35 (9) :2058-2062.
    [9]YOON YC, HONG TH, YOU YK, et al.Clinical analysis of recurrent hepatocellular carcinoma after living donor liver transplantation[J].Clin Transplant, 2013, 27 (2) :e192-e198.
    [10]SHAO CK, ZHOU J, FENG ZY, et al.Influential factors for recurrence and prognosis of hepatocellular carcinoma after liver transplantation[J].Chin J Organ Transplant, 2007, 28 (12) :712-715. (in Chinese) 邵春奎, 周静, 冯智英, 等.影响肝细胞癌患者肝移植后肿瘤复发及预后的相关因素[J].中华器官移植杂志, 2007, 28 (12) :712-715.
    [11]WU C, SHAN H.Analysis of risk factors for recurrence of hepatocellular carcinoma after liver transplantation[J].Natl Med J China, 2012, 92 (29) :2023-2027. (in Chinese) 吴春, 单鸿.肝细胞癌患者肝移植术后肿瘤复发的多因素分析[J].中华医学杂志, 2012, 92 (29) :2023-2027.
    [12]ADLER M, de PAUW F, VEREERSTRAETEN P, et al.Outcome of patients with hepatocellular carcinoma listed for liver transplantation within the Eurotransplant allocation system[J].Liver Transpl, 2008, 14 (4) :526-533.
    [13]SOTIROPOULOS GC, MALAGO M, MOLMENTI E, et al.Liver transplantation for hepatocellular carcinoma in cirrhosis:is clinical tumor classification before transplantation realistic?[J].Transplantation, 2005, 79 (4) :483-487.
    [14]ZHOU J, FAN J, WANG Z, et al.Strategies to improve the efficacy of liver transplantation for hepatocellular carcinoma[J].Chin J Dig Surg, 2011, 10 (4) :253-255. (in Chinese) 周俭, 樊嘉, 王征, 等.提高肝癌肝移植疗效的策略[J].中华消化外科杂志, 2011, 10 (4) :253-255.
    [15]LIANG YB, GENG L.Ideas about current situation of liver transplantation for liver cancer and prevention of postoperative recurrence[J].Natl Med J China, 2011, 91 (22) :1516-1518. (in Chinese) 梁廷波, 耿磊.对肝癌肝移植现状和复发防治的思考[J].中华医学杂志, 2011, 91 (22) :1516-1518.
    [16]MOTOMURA T, SHIRABE K, MANO Y, et al.Neutrophil-lymphocyte ratio reflects hepatocellular carcinoma recurrence after liver transplantation via inflammatory microenvironment[J].J Hepatol, 2013, 58 (1) :58-64.
    [17]HALAZUN KJ, HARDY MA, RANA AA, et al.Negative impact of neutrophil-lymphocyte ratio on outcome after liver transplantation for hepatocellular carcinoma[J].Ann Surg, 2009, 250 (1) :141-151.
    [18]WANG GY, LI H, ZHANG Q, et al.A preoperative prognostic score model to predict recurrence of hepatocellularcarcinoma following liver transplantation[J].Chin J Hepatobiliary surg, 2012, 18 (5) :325-329. (in Chinese) 汪国营, 李华, 张琪, 等.一种预测肝癌肝移植术后肿瘤复发的术前评分模型[J].中华肝胆外科杂志, 2012, 18 (5) :325-329.
    [19]DAI Z, FAN J, ZHOU J, et al.Identification and network analysis of tumor recurrence-related proteins after liver transplantation for hepatocellular carcinoma[J].Chin J Hepatobiliary surg, 2011, 17 (12) :969-973. (in Chinese) 代智, 樊嘉, 周俭, 等.肝癌肝移植术后肿瘤复发相关蛋白的鉴定及生物信息学分析[J].中华肝胆外科杂志, 2011, 17 (12) :969-973.
    [20]MAZZAFERRO V, BATTISTON C, PERRONE S, et al.Radiofrequency ablation of small hepatocellular carcinoma in cirrhotic patients awaiting liver transplantation:a prospective study[J].Ann Surg, 2004, 240 (5) :900-909.
    [21]CLAVIEN PA, LESURTEL M, BOSSUYT PM, et al.Recommendations for liver transplantation for hepatocellular carcinoma:an international consensus conference report[J].Lancet Oncol, 2012, 13 (1) :e11-e22.
    [22]SOLL C, CLAVIEN PA.Inhibition of mammalian target of rapamycin:two goals with one shot?[J].J Hepatol, 2011, 54 (1) :182-183.
    [23]TOSO C, MERANI S, BIGAM DL, et al.Sirolimus-based immunosuppression is associated with increased survival after liver transplantation for hepatocellular carcinoma[J].Hepatology, 2010, 51 (4) :1237-1243.
    [24]ZIMMERMAN MA, TROTTER JF, WACHS M, et al.Sirolimusbased immunosuppression following liver transplantation for hepatocellular carcinoma[J].Liver Transpl, 2008, 14 (5) :633-638.
    [25]TAKAHARA T, NITTA H, HASEGAWA Y, et al.Using sorafenib for recurrent hepatocellular carcinoma after liver transplantation-interactions between calcineurin inhibitor:two case reports[J].Transplant Proc, 2011, 43 (7) :2800-2805.
    [26]STAUFER K, FISCHER L, SEEGERS B, et al.High toxicity of sorafenib for recurrent hepatocellular carcinoma after liver transplantation[J].Transpl Int, 2012, 25 (11) :1158-1164.
    [27]XU J, SHEN ZY, CHEN XG, et al.A randomized controlled trial of Licartin for preventing hepatoma recurrence after liver transplantation[J].Hepatology, 2007, 45 (2) :269-276.
    [28]BATES MJ, FARKAS E, TAYLOR D, et al.Pulmonary resection of metastatic hepatocellular carcinoma after liver transplantation[J].Ann Thorac Surg, 2008, 85 (2) :412-415.
    [29]LEE JO, KIM DY, LIM JH, et al.Palliative chemotherapy for patients with recurrent hepatocellular carcinoma after liver transplantation[J].J Gastroenterol Hepatol, 2009, 24 (5) :800-805.
  • 加载中
计量
  • 文章访问数:  3287
  • HTML全文浏览量:  16
  • PDF下载量:  645
  • 被引次数: 0
出版历程
  • 收稿日期:  2013-11-22
  • 出版日期:  2014-01-20
  • 分享
  • 用微信扫码二维码

    分享至好友和朋友圈

目录

    /

    返回文章
    返回