妊娠期病毒性肝炎临床特点分析

刘惠媛; 应若素; 陈志敏; 廖宝林; 许敏

doi:10.3969/j.issn.1001-5256.2014.11.021

妊娠期病毒性肝炎临床特点分析

DOI: 10.3969/j.issn.1001-5256.2014.11.021

广州市第八人民医院肝病科

基金项目:

广州市科技计划项目(2010GN-E00221)；

详细信息

中图分类号: R714.251
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出版历程
- 收稿日期: 2014-06-24
- 出版日期: 2014-11-20

Analysis of clinical characteristics of viral hepatitis in pregnant women

Liver Disease Branch, The 8th People's Hospital of Guangzhou

Research funding:

摘要

摘要: 目的了解妊娠期病毒性肝炎的临床特点。方法回顾性分析2009年1月至2013年3月于广州市第八人民医院因病毒性肝炎住院的77例妊娠妇女的临床资料,分析肝炎病因、血清病毒学特点、肝损害程度与孕期的相关性。计量资料的组间比较采用Kruskal-Wallis H检验。结果病因:乙型肝炎多见,共72例（93.51%）,有10.27%患者感染甲、乙或戊型肝炎病毒所致急性病毒性肝炎;肝损害程度:中度肝损害64例（83.12%）,重度肝损害7例（9.09%）,肝衰竭3例（3.90%）;肝炎发作时孕期:妊娠早期16例（20.78%）,妊娠中期49例（63.64%）,妊娠晚期12例（15.58%）;肝功能指标:总胆汁酸（TBA）、TBil、白蛋白（Alb）、ALT、AST、凝血酶原活动度（PTA）在HBeAg阳性和阴性患者间,以及在HBV DNA>106IU/ml和HBV DNA≤106IU/ml患者间差异均无统计学意义（P>0.05）。结论妊娠期病毒性肝炎主要由HBV引起,多数引起中度肝损害,重度肝损害或肝衰竭常发生于妊娠中晚期,因此育龄妇女妊娠期须注意防治慢性乙型肝炎。
- 妊娠并发症,感染性 /
- 肝炎,病毒性,人 /
- 肝炎病毒,乙型
Abstract: Objective To study the clinical characteristics of viral hepatitis in pregnancy. Methods A retrospective analysis was performed on 77 pregnant women with viral hepatitis who were admitted to our hospital from January 2009 to March 2013. Cause of hepatitis, serologic and virologic markers, degree of liver damage, and association with the stage of pregnancy were analyzed. Comparison of continuous data between groups was made by Kruskal- Wallis H test. Results The main cause of viral hepatitis in pregnancy was HBV infection (72cases, 93. 51%) , and 10. 27% of patients were infected with hepatitis A, B or E virus. Moderate liver damage was detected in 64 patients (83.12%) , severe liver damage in 7 patients (9.09%) , and liver failure in 3 patients (3.90%) . Sixteen patients (20.78%) were diagnosed with hepatitis in the first trimester of pregnancy, 49 (63. 64%) in the second trimester, and 12 (15. 58%) in the third trimester.Liver function indices, including total bile acid (TBA) , total bilirubin (TBil) , albumin ( Alb) , alanine aminotransferase ( ALT) , aspartate transaminase (AST) , and prothrombin activity (PTA) , were compared between HBeAg ( +) and HBeAg (-) patients and between patients with HBV DNA > 106 IU /ml and ≤106IU /ml, and no significant differences were found in either comparison (P > 0. 05) . Conclusion Viral hepatitis in pregnancy is mainly caused by infection with hepatitis B virus. Liver damage is mostly moderate and severe liver damage and liver failure often occur in the middle or late stage of pregnancy. This study indicates that pregnant women should take precautions and active treatment for chronic hepatitis B.
- pregnancy complications, infectious /
- hepatitis, viral, human /
- hepatitis B virus

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参考文献(10)

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