肠道菌群和胆汁酸代谢对非酒精性脂肪性肝病发生发展的作用

鲁旭; 韩涛; 田垚; 卢博为; 张倩

doi:10.3969/j.issn.1001-5256.2014.11.034

肠道菌群和胆汁酸代谢对非酒精性脂肪性肝病发生发展的作用

DOI: 10.3969/j.issn.1001-5256.2014.11.034

1. 天津医科大学第三中心临床学院,天津市第三中心医院肝内科,天津市人工细胞重点实验室,天津市肝胆疾病研究所
2. 天津市医科大学附属肿瘤医院
3. 厦门大学化学化工学院固体表面物理化学国家重点实验室

基金项目:

艾滋病和病毒性肝炎等重大传染病防治国家科技重大专项(2012ZX10002004-011)；天津市科技计划项目(13RCGFSY19200)；

详细信息

中图分类号: R575
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出版历程
- 收稿日期: 2014-03-19
- 出版日期: 2014-11-20

Research progress in roles of gut microbiota and bile acid metabolism in development and progression of NAFLD

The Third Central Clinical College of Tianjin Medical University

Research funding:

摘要

摘要: 随着肥胖及代谢综合征的流行,非酒精性脂肪性肝病的患病率逐年递增,在该病的发生和发展过程中,肠道菌群和胆汁酸代谢均发挥重要作用。讨论了肠道菌群和胆汁酸代谢之间的关系,重点强调了肠道菌群、胆汁酸和胆汁酸受体在非酒精性脂肪性肝病发生发展的过程中所起到的作用。
- 非酒精性脂肪性肝病 /
- 肠道菌群 /
- 胆汁酸 /
- 胆汁酸受体 /
- 综述
Abstract: With the prevalence of obesity and metabolic syndrome, the incidence of nonalcoholic fatty liver disease (NAFLD) is increasing year by year. Studies have uncovered the important roles of gut microbiota and bile acid metabolism in the development and progression of NAFLD. The roles of gut microbiota, as well bile acid and bile acid receptors, in the development and progression of NAFLD are highlighted.
- nonalcoholic fatty liver disease /
- gut microbiota /
- bile acid /
- bile acid receptor /
- review

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参考文献(27)

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