内质网应激在非酒精性脂肪性肝病发病机制中的作用

王健; 姜曼; 辛永宁; 宣世英

doi:10.3969/j.issn.1001-5256.2014.11.036

内质网应激在非酒精性脂肪性肝病发病机制中的作用

DOI: 10.3969/j.issn.1001-5256.2014.11.036

1. 青岛大学医学院
2. 青岛市消化疾病重点实验室
3. 青岛市市立医院消化内二科
4. 中国海洋大学医药学院

基金项目:

国家自然科学基金项目(81170337/H0304)；

详细信息

中图分类号: R575.5
计量
- 文章访问数: 232
- HTML全文浏览量: 20
- PDF下载量: 230
- 被引次数: 0
出版历程
- 收稿日期: 2014-03-31
- 出版日期: 2014-11-20

Role of endoplasmic reticulum stress in pathogenesis of nonalcoholic fatty liver disease

Qingdao University Medical College

Research funding:

摘要

摘要: 非酒精性脂肪性肝病(NAFLD)的发病率在全球范围内迅速增加,但其发病的确切机制并不十分清楚。一方面探讨内质网应激(ERS)可以通过未折叠氮蛋白反应(URP)促进NAFLD的形成及进展为非酒精性脂肪性肝炎(NASH),另一方面探讨NAFLD的脂质环境,尤其是脂肪酸,又可诱发ERS的发生。从而指出ERS相关信号转导在NAFLD发病机制中的作用,为NAFLD的治疗提供新的思路。
- 内质网 /
- 应激 /
- 脂肪肝 /
- 未折叠蛋白反应 /
- 综述
Abstract: Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver diseases in the world. However, its exact mechanism remains unknown. Recent studies indicate that endoplasmic reticulum stress (ERS) plays an important role in the development of NAFLD and its progression to nonalcoholic steatohepatitis, resulting in inflammation and even cell apoptosis. The role of ERS- associated signaling pathways in the pathogenesis of NAFLD is investigated, thereby providing new ideas for the treatment of NAFLD.
- endoplasmic reticulum /
- stress /
- fatty liver /
- unfolded protein response /
- review

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参考文献(43)

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