预测原发性肝癌肝移植术后复发转移的分子标志物研究进展

陈曼; 张霞

doi:10.3969/j.issn.1001-5256.2014.12.032

预测原发性肝癌肝移植术后复发转移的分子标志物研究进展

DOI: 10.3969/j.issn.1001-5256.2014.12.032

陈曼,
张霞

南京军区福州总医院肝胆内科

基金项目:

国家自然科学基金资助项目(30400524)；南京军区福州总医院创新团队建设专项资助；

详细信息

中图分类号: R735.7
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- 被引次数: 0
出版历程
- 收稿日期: 2014-05-13
- 出版日期: 2014-12-20

Research advances in molecular prediction of recurrence and metastasis of primary liver cancer after liver transplantation

Chen Man,
Zhang Xia

Fujian University of Traditional Chinese Medicine

Research funding:

摘要

摘要: 肝移植是根治原发性肝癌的一个重要的治疗方法,但是术后高复发转移率却严重影响了其治疗肝癌的疗效。随着分子生物学的深入研究,发现了许多与肝癌肝移植术后复发转移相关的指标。主要从基因水平、蛋白质表达、肿瘤标志物、血清病毒等方面对这些指标进行归纳总结,并分析其对肝移植术后肿瘤复发转移的预测价值。认为尽管越来越多的分子标志物被发现,但仍不足以指导临床。因此,仍需继续加强研究,以便寻找合适的分子标志物来预测肿瘤的复发及转移。
- 肝肿瘤 /
- 肝移植 /
- 肿瘤复发,局部 /
- 肿瘤转移 /
- 预测 /
- 综述
Abstract: Liver transplantation is an essential treatment of primary liver cancer, but the postoperative high risk of recurrence and metastasis has seriously affected the effect of liver transplantation. With the development of molecular biology, researchers have found numerous molecular markers potentially related to the recurrence and metastasis of liver cancer after liver transplantation. These markers, including genes, proteins, tumor markers, and serum viruses, are summarized, and their predictive values for tumor recurrence and metastasis after liver transplantation are analyzed. A growing number of molecular markers have been found, but which is not enough for clinical guidance. Therefore, more studies are needed to identify appropriate molecular markers of tumor recurrence and metastasis after liver transplantation.
- liver neoplasms /
- liver transplantation /
- neoplasm recurrence, local /
- neoplasm metastasis /
- forecasting /
- review

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参考文献(38)

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