Value of serum GP73,AFP,and AFP-L3 in diagnosis of liver cancer and recurrence monitoring after radiofrequency ablation
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摘要:
目的探讨高尔基体糖蛋白73(GP73)、甲胎蛋白(AFP)及甲胎蛋白异质体3(AFP-L3)3种血清肿瘤标志物在肝癌诊断及射频消融术后复发监测中的应用价值。方法收集2012年7月-2013年10月吉林大学白求恩第一医院住院患者及体检中心健康者174例,其中初诊肝癌患者86例,肝硬化患者39例,肝炎患者29例,健康对照20例,并对初诊肝癌的37例患者进行射频消融术后3个月的复诊。分别采用酶联免疫法、电化学发光法、亲和吸附层析法检测血清GP73、AFP、AFP-L3的水平。各组血清标本检测数据呈偏态分布,采用非参数检验,总体比较检验采用Kruskal-Wallis H检验,组间两两比较采用Mann-Whitney U检验,配对秩和检验采用Wilcoxon Signed Ranks检验,计数资料采用χ2检验。结果肝癌组GP73、AFP、AFP-L3表达水平均显著高于其他组(P值均<0.05);肝癌组中GP73和AFP-L3阳性率显著高于其他组(P值均<0.05),而肝癌患者中GP73和AFP-L3阳性率显著高于AFP(P值均<0.05);初诊肝癌的37例患者进行术后3个月复...
Abstract:Objective To explore the clinical value of three serum tumor markers,Golgi protein 73( GP73),alpha- fetoprotein( AFP),and AFP- L3,in the diagnosis of liver cancer and recurrence monitoring after radio frequency ablation. Methods A total of 174 patients who visited our hospital from July 2012 to October 2013 were included in the study,consisting of 86 patients with newly diagnosed liver cancer,39 with liver cirrhosis,29 with hepatitis,and 20 healthy controls. Among the patients with newly diagnosed liver cancer,37 were followed up for three months after the radiofrequency ablation. Serum levels of GP73,AFP,and AFP- L3 were measured by ELISA,electrochemiluminescence,and affinity adsorption chromatography,respectively. Nonparametric tests were performed on the results of serum samples from the four groups which showed skewed distribution and were represented by median( quartile interval) [M( P25- P75) ]. Overall comparison was made by Kruskal- Wallis H test,and comparison between groups was made by Mann- Whitney U test. Pair- matching rank- sum test was performed using Wilcoxon Signed Ranks,and categorical data were analyzed by χ2test. Results The levels of GP73,AFP,and AFP- L3 in the liver cancer group were significantly higher than those in other groups( all P < 0. 05). The positive rates of GP73 and AFP- L3 in the liver cancer group were significantly higher than those in other groups( all P < 0. 05),and the positive rates of the two markers were significantly higher than that of AFP among patients with liver cancer( P < 0. 05). Thirty- seven patients with newly diagnosed liver cancer were reexamined three months after radiofrequency ablation,and the preoperational AFP- L3 level in the patients who had recurrence was significantly higher than that in the patients without recurrence( P < 0. 05). Conclusion Serum GP73,AFP,and AFP- L3 show great values in the diagnosis of liver cancer. AFP- L3 can be used as an indicator for the identification of benign or malignant liver disease and risk of recurrence after radiofrequency ablation.
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Key words:
- liver neoplasms /
- golgiprotein 73 /
- alpha-fetoproteins /
- alpha-fetoproteins L3 /
- catheter ablation
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