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Recent research on association between gene polymorphisms of IL-28B and other cytokines and HCV infection
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摘要:
现已证实机体对HCV的反应不仅与病毒本身相关,与一些细胞因子及其基因多态性亦关系密切。介绍了与HCV相关的细胞因子及其基因多态性的研究现状,尤其白细胞介素28B与慢性丙型肝炎的病程、预后密切相关。因此,全面了解宿主细胞因子及其基因多态性,对今后慢性丙型肝炎的临床诊治具有重要意义。
Abstract:It has been confirmed that the body's response to hepatitis C virus( HCV) is not only associated with virus,but also associated with some cytokines and their gene polymorphisms. In this paper,the current research on some cytokines associated with HCV and their gene polymorphisms is reviewed. And it is shown that interleukin- 28 B is closely associated with the course and prognosis of chronic hepatitis C( CHC). Therefore,it is of great significance for the clinical diagnosis and treatment of CHC to investigate host cytokines and their gene polymorphisms.
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Key words:
- hepacivirus /
- interleukins /
- cytokines /
- polymorphism single nudeotide /
- review
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