活血清解汤早期干预对重症急性胰腺炎患者血液流变学及D二聚体、血栓素A2、前列环素I2的影响

沙盈盈; 梁超; 朱晓明; 王雄达; 朱玉华

doi:10.3969/j.issn.1001-5256.2016.04.013

活血清解汤早期干预对重症急性胰腺炎患者血液流变学及D二聚体、血栓素A2、前列环素I2的影响

DOI: 10.3969/j.issn.1001-5256.2016.04.013

上海中医药大学附属岳阳中西医结合医院普外科

基金项目:

上海市教育委员会科研创新项目(2012JW50)；

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中图分类号: R259
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出版历程
- 出版日期: 2016-04-20

Effects of early intervention with Huoxueqingjie decoction on hemorheological parameters and D- dimer,thromboxane A2,and prostaglandin I2 levels in patients with severe acute pancreatitis

Department of General Surgery, Yueyang Hospital of Integrative Chinese & Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine

Research funding:

摘要

摘要:
目的探讨活血清解汤对重症急性胰腺炎（SAP）患者血液流变学及血栓素A2（TXA2）、前列环素I2（PGI2）的影响。方法收集2013年1月-12月于上海中医药大学附属岳阳中西医结合医院住院的SAP患者50例,随机分为治疗组与对照组,2组均采取对症支持治疗,治疗组在此基础上经螺旋型鼻肠管给予活血清解汤2次/d,治疗1周。治疗前及治疗第7天进行血淀粉酶、血液流变学、D二聚体、TXA2和PGI2水平检测。计量资料2组间比较采用配对t检验,计数资料组间比较采用χ2检验。结果与对照组相比,治疗组在治疗第7天的总有效率明显升高（64%vs 88%;χ2=3.947,P=0.047）。治疗组和对照组在治疗第7天时血清淀粉酶、血D二聚体、TXA2和TXA2/PGI2水平均较治疗前降低（P值均<0.01）,治疗组在治疗第7天较同期对照组更...
- 胰腺炎,急性坏死性 /
- 中药疗法 /
- 血液流变学
Abstract:
Objective To investigate the effects of early intervention with Huoxueqingjie decoction on hemorheological parameters and the levels of thromboxane A_2( TXA_2) and prostaglandin I_2( PGI_2) in patients with severe acute pancreatitis. Methods A total of 50 patients with severe acute pancreatitis( SAP) who were hospitalized in our hospital from January to December,2013 were randomly divided into treatment group and control group. The patients in the two groups were given symptomatic / supportive treatment,and those in the treatment group were given Huoxueqingjie decoction twice a day through a spiral nasointestinal tube,with a course of the treatment of 1 week. Blood amylase,hemorheological parameters,and the levels of D- dimer,TXA_2,and PGI_2 were measured before treatment and on the 7th day of treatment. Comparison of normally distributed continuous data between groups was performed by t test,and comparison of categorical data between groups was conducted by chi- square test. Results Compared with the control group,the treatment group had a significant increase in overall response rate on the 7th day of treatment( 64% vs 88%,χ~2= 3. 947,P = 0. 047). On the 7th day of treatment,both groups showed significant reductions in the serum levels of amylase,D- dimer,and TXA2 and TXA_2/ PGI_2ratio( all P < 0. 01),and the treatment group had significantly lower levels of these parameters than the control group( P < 0. 05 or P < 0. 01). On the 7th day of treatment,both groups showed a significant increase in PGI_2 level( both P < 0. 01),and the treatment group had a significantly higher PGI_2 level than the control group( P < 0. 01). On the 7th day of treatment,both groups showed significant reductions in all hemorheological parameters,high,middle,and low blood viscosity,plasma viscosity,whole blood reduced viscosity at high or low shear rate,hematocrit,erythrocyte rigidity index,erythrocyte aggregation index,equation K value of erythrocyte sedimentation rate,erythrocyte deformation index,and erythrocyte sedimentation rate( P < 0. 05 or P < 0. 01),and the treatment group had significantly lower hemorheological parameters than the control group( P < 0. 05 or P < 0. 01). Conclusion Traditional Chinese medicine Huoxueqingjie decoction can improve hemorheological parameters,inhibit the increase in D- dimer,maintain the balance between TXA2 and PGI2and therefore plays an important role in the treatment of SAP.
- pancreatitis,acute necrotizing /
- drug therapy(TCD) /
- hemorheology

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