健康体检成人FibroScan检测肝脏硬度值与年龄、性别的相关性

赵崇山; 何文艳; 王宁方; 耿华; 安红杰; 赵宝生; 高美丽; 徐金凤

doi:10.3969/j.issn.1001-5256.2016.04.023

健康体检成人FibroScan检测肝脏硬度值与年龄、性别的相关性

DOI: 10.3969/j.issn.1001-5256.2016.04.023

1. 中国石油天然气集团公司中心医院感染科
2. 中国石油天然气集团公司中心医院血液科

基金项目:

廊坊市科技计划项目(2014-013003)；

详细信息

中图分类号: R575
计量
- 文章访问数: 389
- HTML全文浏览量: 41
- PDF下载量: 140
- 被引次数: 0
出版历程
- 出版日期: 2016-04-20

Correlation of liver stiffness measured by Fibro Scan with sex and age in healthy adults undergoing physical examination

Department of Infectious Diseases, China National Petroleum Corporation Central Hospital

Research funding:

摘要

摘要:
目的界定正常人群肝脏硬度值参考范围及探讨年龄、性别对肝脏硬度值的影响。方法收集2012年10月1日-2014年10月31日于中国石油天然气集团公司中心医院进行体检的健康人群1794例,经Fibro Scan进行肝脏硬度值（LSM）检测。因LSM的分布不服从正态分布,采用Wilcoxon秩和检验比较不同性别组间LSM;采用Kruskal-Wallis检验比较不同年龄段间LSM,采用Spearman秩相关分析LSM与年龄的相关性;采用单侧百分位法制订性别、年龄段的正常参考值范围。结果其中1590例LSM测定成功有效,有效率为88.63%,107例因肝功能异常被剔除,经分析发现男性受试者LSM高于女性受试者,男女间比较LSM差异有统计学意义（Z=-4.980,P<0.001）;不同年龄段间LSM差异亦有统计学意义（χ2=16.983,P=0.001）,并证实年龄与LSM呈正相关（r=0.087,P=0.001）,参考范围（P90）估计:成人≤7.1 k Pa,女性≤7.0 k Pa,男性≤7.2 k Pa;按年龄划分202
- 弹性成像技术 /
- 肝脏硬度值 /
- 性别因素 /
- 年龄分布 /
- 参考值
Abstract:
Objective To determine the reference range of liver stiffness in healthy population,and to investigate the influence of age and sex on liver stiffness. Methods A total of 1794 healthy subjects who underwent physical examination in China National Petroleum Corporation Central Hospital from October 1,2012 to October 31,2014 were enrolled,and Fibro Scan was used to perform liver stiffness measurement( LSM). Since LSM value was not normally distributed,the Wilcoxon rank sum test was used to compare LSM value between male and female patients,the Kruskal- Wallis test was used to compare LSM value between different age groups,and the Spearman's rank correlation analysis was used to analyze the correlation between LSM value and age. The one- sided percentile method was used to determine the range of normal reference values in male and female subjects or in different age groups. Results LSM was successfully performed in 1590 patients,and the rate of successful measurement was 88. 63%. A total of 107 patients were excluded due to abnormal liver enzymes. The analysis showed that LSM value showed a significant difference between male and female subjects( Z =- 4. 980,P < 0. 001),as well as between different age groups( χ~2= 16. 983,P = 0. 001). Age was positively correlated with LSM value( r = 0. 087,P = 0. 001). The reference range was estimated to be ≤7. 1 k Pa in adults,≤7. 0 k Pa in females,and ≤7. 2 k Pa in males. From the perspective of age,the reference range was estimated to be ≤6. 8 k Pa in persons aged 20- 29 years,≤6. 7 k Pa in persons aged 30- 44 years,≤7. 8 k Pa in persons aged 45- 59 years,and ≤8. 8 k Pa in persons aged 60- 74 years. Conclusion Liver stiffness value is influenced by sex and age. Sex and age should be taken into account while performing liver stiffness measurement in healthy subjects.
- elasticity imaging technigues /
- liver stiffness measurement /
- sex factors /
- age distribution /
- reference values

HTML全文

参考文献(16)

[1]SANDRIN L,FOURQUET B,HASQUENOPH JM,et al.Transient elastography:a new noninvasive method for assessment of hepatic fibrosis[J].Ultrasound Med Biol,2003,29(12):1705-1713.

[2]LIU LF,LU HY,YU YY,et al.A comparative study of FibroS can and B ultrasound in diagnosis of liver fibrosis[J].J Clin Hepatol,2014,30(10):1045-1049.(in Chinese)刘玲峰,陆海英,于岩岩,等.FibroS can检测与超声检查对肝纤维化程度诊断价值的对比分析[J].临床肝胆病杂志,2014,30(10):1045-1049.

[3]LIU HB,WANG N,SHAN H,et al.Significance of FibroS can examination in hepatitis B virus-infected patients with normal ALT[J].J Clin Hepatol,2015,31(2):198-201.(in Chinese)刘洪波,王宁,单洪,等.FibroS can对ALT正常的HBV感染者的诊断价值[J].临床肝胆病杂志,2015,31(2):198-201.

[4]OLIVER F,COCO B,CICCOROSSI P,et al.Liver stiffness in the hepatitis B virus carrier:a non-invasive marker of liver disease influenced by the pattern of transaminases[J].World J Gastroenterol,2008,14(40):6154-6162.

[5]SAITO H,TADA S,NAKAMOTO N,et al.Efficacy of non-invasive elastometry on staging of hepatic fibrosis[J].Hepatol Res,2004,29(2):97-103.

[6]ZENG XH,SHI DR,WANG YM.New clinical progress in diagnosing liver disease using FibroS can[J].Chin J Pract Intern Med,2014,34(12):1185-1188.(in Chinese)曾祥华,石代蓉,王宇明.FibroS can用于慢性肝病临床诊治新进展[J].中国实用内科杂志,2014,34(12):1185-1188.

[7]ROULOT D,CZERNICHOW S,LE CLSIAU H,et al.Liver stiffness values in apparently healthy subjects:influence of gender and metabolic syndrome[J].J Hepatol,2008,48(4):606-613.

[8]LU JF,LIU TB,PAN Q,et al.A correlation of liver stiffness to controlled attenuation parameter in healthy individuals[J].J Pract Hepatol,2014,17(5):484-488.(in Chinese)卢加发,刘文斌,潘勤,等.健康体检成人FibroS can检测肝脏硬度值与受控衰减参数的相关分析[J].实用肝脏病杂志,2014,17(5):484-488.

[9]ALSEBAEY A,ALLAM N,ALSWAT K,et al.Normal liver stiffness:a study in living donors with normal liver histology[J].World J Hepatol,2015,7(8):1149-1153.

[10]FOUCHER J,CASTERA L,BERNALD PH,et al.Prevalence and factors associated with failure of liver stiffness measurement using FibroS can in a prospective study of 2114 examinations[J].Eur J Gastroenterol Hepatol,2006,18(4):411-412.

[11]CORPECHOT C,EL NAGGAR A,POUPON R,et al.Gender and liver:is the liver stiffness weaker in weaker sex?[J].Hepatology,2006,44(2):513-514.

[12]YANG JD,ABDELMALEK MF,PANG H,et al.Gender and menopause impact severity of fibrosis among patients with nonalcoholic steatohepatitis[J].Hepatology,2014,59(4):1406-1414.

[13]TUROLA E,PETTA S,VANNI E,et al.Ovarian senescence increases liver fibrosis in humans and zebrafish with steatosis[J].Dis Model Mech,2015,8(9):1037-1046.

[14]NING SY,LI NH,HAN XY,et al.Aging changes in routine blood cell count and its reference range in the elderly in Beijing community[J].Chin J Geriatr,2014,33(11):1227-1230.(in Chinese)宁尚勇,李宁华,韩晓燕,等.北京城区老年人血细胞计数增龄变化及变化范围的调查[J].中华老年医学杂志,2014,33(11):1227-1230.

[15]YIN SM,ZHENG SB,ZHOU Y.Age-related changes in serum levels of albumin,globulin,and hemoglobin in a healthy population[J].Chin J Gerontol,2010,30(9):1201-1203.(in Chinese)尹曙明,郑松柏,周骅.健康正常人群血清白蛋白、球蛋白、血红蛋白水平的增龄变化[J].中国老年学杂志,2010,30(9):1201-1203.

[16]SIRLI R,SPOREA I,BOTA S,et al.Factors influencing reliability of liver stiffness measurements using transient elastography(M-probe)-Monocentric experience[J].Eur J Radiol,2013,82(8):e313-e316.

施引文献

资源附件(0)

访问统计