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引用本文:
Citation:

中草药相关肝损伤临床诊疗指南

DOI: 10.3969/j.issn.1001-5256.2016.05.003
详细信息
  • 中图分类号: R259

  • 摘要:

    <正>中草药相关肝损伤(herb-induced liver injury,HILI)是指由中药、天然药物及其相关制剂引发的肝损伤。近年来,随着中草药在全球的广泛应用及药品不良反应监测体系的不断完善,HILI报道呈升高趋势,中草药相关因素引起的药物性肝损伤(drug-induced liver injury,DILI)越来越受到关注[1]。影响HILI发生的因素复杂多样,有药物方面因素,也有药物应用不

     

  • [1]CHALASANI NP,HAYASHI PH,BONKOVSKY HL,et al.ACG Clinical Guideline:the diagnosis and management of idiosyncratic drug-induced liver injury[J].Am J Gastroenterol,2014,109(7):950-966;quiz 967.
    [2]TESCHKE R,WOLFF A,FRENZEL C,et al.Review article:herbal hepatotoxicity-an update on traditional Chinese medicine preparations[J].Aliment Pharmacol Ther,2014,40(1):32-50.
    [3]ZHU Y,NIU M,CHEN J,et al.Comparison between Chinese herbal medicine and western medicine-induced liver injury of1985 patients[J].J Gastroenterol Hepatol,2016.[Epub ahead of print]
    [4]GRADE Working Group.Grading quality of evidence and strength of recommendations[J].BMJ,2004,328(7454):1490-1497.
    [5]TESCHKE R,SCHWARZENBOECK A,EICKHOFF A,et al.Clinical and causality assessment in herbal hepatotoxicity[J].Expert Opin Drug Saf,2013,12(3):339-366.
    [6]ZHOU Y,YANG L,LIAO Z,et al.Epidemiology of drug-induced liver injury in China:a systematic analysis of the Chinese literature including 21 789 patients[J].Eur J Gastroenterol Hepatol,2013,25(7):825-829.
    [7]Cooperative Group of Hepatobiliary Disease of Digestive Disease Branch of Chinese Medical Association.A multicenter survey on hospital inpatients with drug-induced acute liver injury in China[J].Chin J Dig,2007,27(7):439-442.(in Chinese)中华医学会消化病学分会肝胆疾病协作组.全国多中心急性药物性肝损伤住院病例调研分析[J].中华消化杂志,2007,27(7):439-442.
    [8]CHEN CM,CHANG B,ZHANG D,et al.Etiology and injury types of drug-induced liver indury in Shenyang[J].World Chin J Dig,2008,16(22):2525-2528.(in Chinese)陈昶铭,常冰,张岱,等.沈阳地区药物性肝损伤病因和损伤类型[J].世界华人消化杂志,2008,16(22):2525-2528.
    [9]NAVARRO VJ,BARNHART H,BONKOVSKY HL,et al.Liver injury from herbals and dietary supplements in the U.S.Drug-Induced Liver Injury Network[J].Hepatology,2014,60(4):1399-1408.
    [10]CHALASANI N,BONKOVSKY HL,FONTANA R,et al.Features and outcomes of 899 patients with drug-induced liver injury:the DILIN prospective study[J].Gastroenterology,2015,148(7):1340-1352.
    [11]SUK KT,KIM DJ,KIM CH,et al.A prospective nationwide study of drug-induced liver injury in Korea[J].Am J Gastroenterol,2012,107(9):1380-1387.
    [12]TAKIKAWA H,MURATA Y,HORIIKE N,et al.Drug-induced liver injury in Japan:an analysis of 1676 cases between 1997 and 2006[J].Hepatol Res,2009,39(5):427-431.
    [13]ZHU Y,LI YG,WANG Y,et al.Analysis of clinical characteristics in 595 patients with herb-induced liver injury[J].Chin J Integr Tradit West Med(Chin),2016,36(1):38-42.(in Chinese)朱云,李永纲,王葽,等.595例中药导致肝损伤临床特征分析[J].中国中西医结合杂志,2016,36(1):38-42.
    [14]CHALASANI N,FONTANA RJ,BONKOVSKY HL,et al.Causes,clinical features,and outcomes from a prospective study of drug-induced liver injury in the United States[J].Gastroenterology,2008,135(6):1924-1934.
    [15]CHEN YF,CAI HD.Investigation of liver damage associated with traditional Chinese medicines[J].ADRJ,1999,1:27-31.(in Chinese)陈一凡,蔡皓东.中药引起肝损害的调查分析.药物不良反应杂志,1999,1:27-31.
    [16]WU XN,YOU H,JIA JD.Clinical features of drug-induced liver injury:a review of Chinese literatures 2003-2007[J].Chin Hepatol,2008,13(6):463-466.(in Chinese)吴晓宁,尤红,贾继东.2003-2007年国内药物性肝损伤临床特点文献综合分析[J].肝脏,2008,13(6):463-466.
    [17]PELKONEN O,TURPEINEN M,HAKKOLA J,et al.Inhibition and induction of human cytochrome P450 enzymes:current status[J].Arch Toxicol,2008,82(10):667-715.
    [18]LIN G,WANG JY,LI N,et al.Hepatic sinusoidal obstruction syndrome associated with consumption of gynura segetum[J].J Hepatol,2011,54(4):666-673.
    [19]DENG WL.Toxicological studies of tripterigyum willfordii[J].Pharmocol Clin Chin Mater Med,2001,17(3):42-47.(in Chinese)邓文龙.雷公藤中毒及毒副反应报告研究[J].中药药理与临床,2001,17(3):42-47.
    [20]TESCHKE R.Traditional Chinese medicine induced liver injury[J].J Clin Translat Hepatol,2014,2(2):80-94.
    [21]TU C,JIANG BQ,ZHAO YL,et al.Comparison of processed and crude polygoni multiflori radix induced rat liver injury and screening for sensitive indicators[J].China J Chin Mater Med,2015,40(4):654-660.(in Chinese)涂灿,蒋冰倩,赵艳玲,等.何首乌炮制前后对大鼠肝脏的损伤比较及敏感指标筛选[J].中国中药杂志,2015,40(4):654-660.
    [22]EFFERTH T,KAINA B.Toxicities by herbal medicines with emphasis to traditional Chinese medicine[J].Curr Drug Metab,2011,12(10):989-996.
    [23]STICKEL F,SHOUVAL D.Hepatotoxicity of herbal and dietary supplements:an update[J].Arch Toxicol,2015,89(6):851-865.
    [24]HU YY,HUANG P.Comparison of processed and crude Polygoni Multiflori Radix induced rat liver injury and screening for sensitive indicators[J].Chin J Hepatol,2012,20(3):173-175.(in Chinese)胡义扬,黄甫.中草药与药物性肝损伤[J].中华肝脏病杂志,2012,20(3):173-175.
    [25]NAVARRO VJ,LUCENA MI.Hepatotoxicity induced by herbal and dietary supplements[J].Semin Liver Dis,2014,34(2):172-193.
    [26]Drug induced Liver Disease Study Group,Chinese society of Hepatology,Chinese Medical Association.Guidelines for the management of drug-induced liver injury[J].J Clin Hepatol,2015,31(11):1752-1769.(in Chinese)中华医学会肝病学分会药物性肝病学组.药物性肝损伤诊治指南[J].临床肝胆病杂志,2015,31(11):1752-1769.
    [27]Drug-induled Liver Disease Study Group,Chinese Society of Hepatology,Chinese Medical Association.Interpretation of the guidelines for the management of drug-induced liver injury[M].Shanghai:Shanghai Scientific&Technical Publishers,2015:1-6.(in Chinese)中华医学会肝脏病学分会药物性肝病学组.药物性肝损伤诊治指南解读[M].上海:上海科学技术出版社,2015:1-6.
    [28]WU MH,WANG XY.Chinese Internal Medicine[M].Beijing:China Press of Traditional Chinese Medicine,2012:243.(in Chinese)吴勉华,王新月.中医内科学[M].北京:中国中医药出版社,2012:243.
    [29]ZHU Y,CHENG JD,WANG LF,et al.Research overview of traditional Chinese medicine treatment for drug-induced liver injury[J].Chin J Integr Tradit West Med Liver Dis,2014,24(4):254-256.(in Chinese)朱云,成佳黛,王立福,等.中医药治疗药物性肝损伤的研究概况[J].中西医结合肝病杂志,2014,24(4):254-256.
    [30]LIU FF,DUAN XZ,ZANG H,et al.Comparative analysis of clinical and hepatic pathologic features in patients with acute drug-induced;liver injury caused by traditional Chinese herbs and western medicines[J].J Pract Hepatol,2013,16(4):317-319.(in Chinese)柳芳芳,段学章,臧红,等.中药和西药致急性药物性肝损伤临床和肝组织病理学特征对比分析[J].实用肝脏病杂志,2013,16(4):317-319.
    [31]LI C,LIANG XS,LI CZ.Sinusoidal obstruction syndrome associated with the ingestion of gynura root[J].Clin Toxicol(Phila),2010,48(9):962-964.
    [32]TESCHKE R,GENTHNER A,WOLFF A,et al.Herbal hepatotoxicity:analysis of cases with initially reported positive re-exposure tests[J].Dig Liver Dis,2014,46(3):264-269.
    [33]TESCHKE R,FRENZEL C,SCHULZE J,et al.Herbalife hepatotoxicity:evaluation of cases with positive reexposure tests[J].World J Hepatol,2013,5(7):353-363.
    [34]ERNST E.Adulteration of Chinese herbal medicines with synthetic drugs:a systematic review[J].J Intern Med,2002,252(2):107-113.
    [35]WANG JB,MA ZJ,NIU M,et al.Evidence chain-based causality identification in herb-induced liver injury:exemplification of awell-known liver-restorative herb Polygonum multiflorum[J].Front Med,2015,9(4):457-467.
    [36]AITHAL GP,WATKINS PB,ANDRADE RJ,et al.Case definition and phenotype standardizationin drug-induced liver injury[J].Clin Pharmacol Ther,2011,89(6):806-815.
    [37]DANAN G,BENICHON C.Causality assessment of adverse risks to drugs:a novel method based on the conclusions of international consensus meetings and applications to drug-induced liver injuries[J].J Clin Epidemiol,1993,46(11):1323-1330.
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