胆外疾病与胆囊结石相关性的研究进展

李娟; 魏小果; 卢启明; 詹丽; 柳鹏程

doi:10.3969/j.issn.1001-5256.2016.05.050

胆外疾病与胆囊结石相关性的研究进展

DOI: 10.3969/j.issn.1001-5256.2016.05.050

1. 甘肃省人民医院消化科
2. 兰州大学第二临床医学院

详细信息

中图分类号: R575.62
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出版历程
- 出版日期: 2016-05-20

Research advances in association between diseases outside the gallbladder and gallstones

摘要

摘要: 胆囊结石是我国常见的消化系疾病之一,其发病机制复杂,多认为是在遗传背景下,由多种因素介导而成,包括胆汁胆固醇过饱和、肠道胆固醇吸收过多、胆汁中胆固醇成核异常、胆囊动力学功能障碍及胆汁淤积等。回顾性分析了上述机制对胆外疾病与胆囊结石形成之间的关系,着重探讨了代谢综合征、肝脏疾病、胃肠道疾病等与胆囊结石形成的相关性。基于目前的研究证据,以上疾病可能促进胆囊结石的形成,通过对以上胆外疾病的积极干预,可望为胆囊结石的防治拓展新的思路。
- 胆囊结石病 /
- 代谢综合征X /
- 肝疾病 /
- 胃肠疾病 /
- 肠杆菌科 /
- 综述
Abstract: Gallstones is a common digestive system disease in China and has a complex pathogenesis. It is often considered that it is mediated by many factors in the genetic background,including biliary cholesterol supersaturation,intestinal cholesterol hyperabsorption,abnormal cholesterol nucleation in bile,dysfunction in gallbladder dynamics,and cholestasis. This article reviews the role of the above mechanisms in the association between diseases outside the gallbladder and gallstones. Based on current evidence,the above diseases may promote the formation of gallstones,and active intervention of the above diseases outside the gallbladder may help to expand new strategies for the prevention and treatment of gallstones.
- cholecystolithiasis /
- metabolic syndrome X /
- liver diseases /
- gastrointestinal diseases /
- enterobacteriaceae /
- review

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参考文献(40)

[1]BASS G,GILANI SN,WALSH TN.Validating the 5Fs mnemonic for cholelithiasis:time to include family history[J].Postgrad Med J,2013,89(1057):638-641.

[2]FRADIN K,RACINE AD,BELAMARICH PF.Obesity and symptomatic cholelithiasis in childhood:epidemiologic and case-control evidence for a strong relation[J].J Pediatr Gastroenterol Nutr,2014,58(1):102-106.

[3]GU YC,HE XD,YU JC,et al.Metabolism-related risk factors of cholelithiasis among Beijing residents:a case-control study[J].Acta Acad Med Sin,2012,34(1):38-40.(in Chinese)古应超,何小东,于健春,等.北京地区代谢因素与胆囊结石患病风险的病例对照研究[J].中国医学科学院学报,2012,34(1):38-40.

[4]ATAMER A,OVUNC AO,YESIL A,et al.Evaluation of leptin and insulin resistance in patients with cholelithiasis[J].Indian J Biochem Biophys,2013,50(4):266-272.

[5]SARAC S,ATAMER A,ATAMER Y,et al.Leptin levels and lipoprotein profiles in patients with cholelithiasis[J].J Int Med Res,2015,pii:0300060514561134.

[6]HYOGO H,ROY S,PAIGEN B,et al.Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts[J].J Biol Chem,2002,277(37):34117-34124.

[7]CHAIT A,BIERMAN EL,ALBERS JJ.Low-density lipoprotein receptor activity in cultured human skin fibroblasts.Mechanism of insulin-induced stimulation[J].J Clin Invest,1979,64(5):1309-1319.

[8]LORIA P,LONARDO A,LOMBARDINI S,et al.Gallstone disease in non-alcoholic fatty liver:prevalence and associated factors[J].J Gastroenterol Hepatol,2005,20(8):1176-1184.

[9]FRACANZANI AL,VALENTI L,RUSSELLO M,et al.Gallstone disease is associated with more severe liver damage in patients with non-alcoholic fatty liver disease[J].PLoS One,2012,7(7):e41183.

[10]RAMOS-de la MA,REMES-TROCHE JM,ROESCH-DIETLEN FB,et al.Routine liver biopsy to screen for nonalcoholic fatty liver disease(NAFLD)during cholecystectomy for gallstone disease:is it justified?[J].J Gastrointest Surg,2008,12(12):2097-2102.

[11]KOLLER T,KOLLEROVA J,HLAVATY T,et al.Cholelithiasis and markers of nonalcoholic fatty liver disease in patients with metabolic risk factors[J].Scand J Gastroenterol,2012,47(2):197-203.

[12]CHEN YF,WU ZJ.Pathogenesis and risk factors of cholesterol gallstones in patients with non-alcoholic fatty liver disease[J].J Clin Hepatol,2013,29(12):952-955.(in Chinese)陈永芳,吴战军.非酒精性脂肪性肝病患者并发胆固醇胆结石的发病机制及危险因素[J].临床肝胆病杂志,2013,29(12):952-955.

[13]LI CP,HWANG SJ,LEE FY,et al.Evaluation of gallbladder motility in patients with liver cirrhosis relationship to gallstone formation[J].Dig Dis Sci,2000,45(6):1109-1114.

[14]COELHO JC,SLONGO J,DAMBROSKI SILVA A,et al.Prevalence of cholelithiasis in patients subjected to liver transplantation for cirrhosis[J].J Gastrointestin Liver Dis,2010,19(4):405-408.

[15]BUTT Z,HYDER Q.Cholelithiasis in hepatic cirrhosis:evaluating the role of risk factors[J].J Pak Med Assoc,2010,60(8):641-644.

[16]LIU XW,LU XH.Incidence of gallstones with cirrhosis patients[J].Chin J Clin Gastroenterol,1993,5(1):14-15.(in Chinese)刘喜文,陆星华.肝硬化患者胆结石的发生率[J].临床消化病杂志,1993,5(1):14-15.

[17]POMERANZ IS,SHAFFER EA.Abnormal gallbladder emptying in a subgroup of patients with gallstone[J].Gastroenterology,1985,88(3):787.

[18]LUO M,SUN YW,WU ZY,et al.The motility of the gallbladder in patients with liver cirrhosis[J].J Surg Pract,2002,7(4):283-286.(in Chinese)罗蒙,孙勇伟,吴志勇,等.肝硬化伴胆囊结石病人的胆囊动力学研究[J].外科理论与实践,2002,7(4):283-286.

[19]FORNARI F,CIVATDI G,BUSCATINI E,et al.Cirrhosis of the liver-a risk factor for development of cholelithiasis males[J].Dig Dis Sci,1990,35(11):1403-1408.

[20]ZHU JF,SHAN KC,DONG L,et al.Changes in gallbladder contraction function in patients with cirrhotic portal hypertension[J].Chin J Surg,1993,31(1):34-36.(in Chinese)朱江帆,单孔成,董磊,等.肝硬变门静脉高压症胆囊收缩功能的改变[J].中华外科杂志,1993,31(1):34-36.

[21]MILOVANOVIC B,MILINIC N,TRIFUNOVIC D,et al.Autonomic dysfunction in alcoholic cirrhosis and its relation to sudden cardiac death risk predictors[J].Gen Physiol Biophys,2009,28(1):251-261.

[22]CHAWLA A,PUTHUMANA L,THULUVATH PJ.Autonomic dysfunction and cholelithiasis in patients with cirrhosis[J].Dig Dis Sci,2001,46(3):495-498.

[23]VAKHRUSHEV IaM,GORBUNOV AIU,TRONINA DV,et al.Cholelithiasis as a possible manifestation of systemic digestive diseases[J].Ter Arkh,2015,87(2):54-58.

[24]XIAN GZ,WU SD,CHEN CC,et al.Western blotting in the diagnosis of duodenal-biliary and pancreaticobiliary refluxes in biliary diseases[J].Hepatobiliary Pancreat Dis Int,2009,8(6):608-613.

[25]WU SD,YU H,WANG HL,et al.The relationship between Oddi's sphincter and bile duct pigment gallstone[J].Chin J Surg,2007,45(1):58-61.(in Chinese)吴硕东,于宏,王昊霖,等.Oddi括约肌与胆管色素结石形成关系的探讨[J].中华外科杂志,2007,45(1):58-61.

[26]TOMTITCHONG P,TIEMTANOM S,EIAMTRAKUL S,et al.Gastroduodenal pathology in patients with asymptomatic gallbladder stones[J].Hepatogastroenterology,2014,61(129):236-239.

[27]WU WC,ZHAO W,LI S.Small intestinal bacteria overgrowth decreases small intestinal motility in the NASH rats[J].World J Gastroenterol,2008,14(2):313-317.

[28]KAUR J,RANA SV,GUPTA R,et al.Prolonged orocecal transit time enhances serum bile acids through bacterial overgrowth,contributing factor to gallstone disease[J].J Clin Gastroenterol,2014,48(4):365-369.

[29]WANG DQ,COHEN DE,CAREY MC.Biliary lipids and cholesterol gallstone disease[J].J Lipid Res,2009,50(Suppl):s406-s411.

[30]FAN Y,WU SD,SUN L,et al.Possible relationship between intestinal barrier function and formation of pigment gallstones in hamsters[J].Hepatobiliary Pancreat Dis Int,2008,7(5):529-532.

[31]SUN SL,WU SD,SUI DM,et al.Determination of intestinal permeability in cholelithiasis patients by oral administration of technetium-99m-diethylenetriaminepentaacetatic acid[J].Natl Med J China,2007,87(7):464-467.(in Chinese)孙韶龙,吴硕东,隋东明,等.口服99Tmc-DTPA检测胆石症患者肠黏膜通透性[J].中华医学杂志,2007,87(7):464-467.

[32]BAI SY,XIAO SJ,WEI N.Clinical study of changes in intestinal permeability in patients with gallstones of different distribution and properties[J].J Clin Hepatol,2014,30(6):546-548.(in Chinese)白顺滟,肖思洁,魏娜.不同部位及性质胆石症患者肠黏膜通透性改变的临床分析[J].临床肝胆病杂志,2014,30(6):546-548.

[33]SAYIN SI,WAHLSTROM A,FELIN J,et al.Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid,a naturally occurring FXR antagonist[J].Cell Metab,2013,17(2):225-235.

[34]WU T,ZHANG Z,LIU B,et al.Gut microbiota dysbiosis and bacterial community assembly associated with cholesterol gallstones in large-scale study[J].BMC Genomics,2013,14:669.

[35]WEGRZYN P,POPIOLEK M,PRZYBYLOWSKI P,et al.The risk of cholelithiasis in patients after heart transplantation[J].Arch Med Sci,2014,10(1):53-57.

[36]SHIINA Y,TOYODA T,KAWASOE Y,et al.The prevalence and risk factors for cholelithiasis and asymptomatic gallstones in adults with congenital heart disease[J].Int J Cardiol,2011,152(2):171-176.

[37]BHADADA SK,BHANSALI A,SHAH VN,et al.High prevalence of cholelithiasis in primary hyperparathyroidism:a retrospective analysis of 120 cases[J].Indian J Gastroenterol,2011,30(2):100-101.

[38]QIN J,LI Y,CAI Z,et al.A metagenome-wide association study of gut microbiota in type 2 diabetes[J].Nature,2012,490(7418):55-60.

[39]LI F,JIANG C,KRAUSZ KW,et al.Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity[J].Nat Communi,2013,4(3):2384.

[40]QIN N,YANG F,LI A,et al.Alterations of the human gut microbiome in liver cirrhosis[J].Nature,2014,513(7516):59-64.

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