236例原发性肝癌患者流行病学及临床特点分析

赵荣荣; 邓永东; 袁宏

doi:10.3969/j.issn.1001-5256.2016.08.021

236例原发性肝癌患者流行病学及临床特点分析

DOI: 10.3969/j.issn.1001-5256.2016.08.021

兰州大学第一医院感染科

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中图分类号: R735.7
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出版历程
- 收稿日期: 2016-02-14
- 出版日期: 2016-08-20

Epidemiological and clinical features of primary liver cancer: an analysis of 236 patients

Department of Infectious Diseases,The First Hospital of Lanzhou University

摘要

摘要: 目的探讨原发性肝癌（PLC）患者的流行病学及临床特点。方法收集2012年8月-2014年8月兰州大学第一医院收治的236例信息相对完善、首次确诊为PLC患者的临床资料,分析其流行病学及临床特点。计数资料组间比较采用χ2检验。结果236例PLC患者中,男198例（83.9%）,女38例（16.1%）,其中4160岁人群发病率（58.5%,138/236）最高。19例患者具有肝癌家族史,28例患者既往有大量饮酒史,34例患者合并2型糖尿病,44例合并高血压病。232例（98.3%）患者是在慢性肝病基础上发生PLC,4例（1.7%）无慢性肝病。具有单纯慢性HBV感染者207例（87.7%）,单纯慢性HCV感染者14例（5.9%）,HBV/HCV重叠感染者5例（2.1%）,单纯慢性酒精性肝炎6例（2.5%）。212例HBV感染者中,HBe Ag阳性慢性乙型肝炎患者51例（24.1%）,HBe Ag阴性慢性乙型肝炎患者95例（44.8%）,两组HBV DNA复制水平比较差异有统计学意义（χ2=40.687,P=0.001）。所有PLC患者中,甲胎蛋白>400 IU/m...
- 肝肿瘤 /
- 流行病学研究
Abstract: Objective To investigate the epidemiological and clinical features of patients with primary liver cancer( PLC). Methods A retrospective analysis was performed for the clinical data of 236 patients with complete information who were admitted to The First Hospital of Lanzhou University and diagnosed with PLC for the first time form August 2012 to August 2014,and their epidemiological and clinical features were analyzed. The chi- square test was used for comparison of categorical data between groups. Results Among the 236 PLC patients,there were 198 male patients( 83. 9%) and 38 female patients( 16. 1%),and the patients aged 41- 60 years has the highest incidence rate( 58. 5%,138 /236). Nineteen patients had a family history of liver cancer,28 had a history of heavy drinking,34 were complicated by type 2 diabetes,and 44 were complicated by hypertension. Among these patients,232( 98. 3%) developed PLC on the basis of chronic liver disease,and 4( 1. 7%) had no chronic liver disease. There were 207 patients( 87. 7%) with chronic HBV infection,and most of them had HBe Ag- negative infection. Fourteen patients( 5. 9%) had chronic HCV infection,5( 2. 1%) had HBV / HCV co- infection,and 6( 2. 5%) had chronic alcoholic hepatitis. Among the 212 patients with HBV infection,51( 24. 1%) had HBe Ag- positive chronic hepatitis B,and 95( 44. 8%) had HBe Ag- negative chronic hepatitis B; there was significant difference in HBV DNA level between the two groups( χ2= 40. 687,Ρ = 0. 001). Among all the PLC patients,104 had an alpha- fetoprotein( AFP) level of > 400 IU / ml,48 had an AFP level of 200- 400 IU / ml,and 84 had an AFP level of < 200 IU / ml; 154( 62. 3%) had a single lesion,and 72( 30. 5%) had multiple lesions; most( 72. 7%) of patients with a single lesion had the single lesion in the right lobe,and the proportions of patients with multiple lesions in the right lobe and in both lobes accounted for 58. 3% and 41. 7%,respectively. Among the 80 PLC patients with pathological results,most( 85%) had hepatocellular carcinoma. Conclusion PLC has certain distribution patterns in sex,age of onset,family history of liver cancer,etiology,tumor position,number of tumors,and pathological histology. The factors involved in the development and progression of PLC need in- depth investigation,in order to develop good control strategies. Moreover,the association of PLC with chronic metabolic diseases such as diabetes and hypertension awaits further investigation.
- liver neoplasms /
- epidemiology studies

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