血清CRP、降钙素原及脂肪酶对妊娠合并重症急性胰腺炎的预判价值

黎先萍; 李娟

doi:10.3969/j.issn.1001-5256.2016.10.024

血清CRP、降钙素原及脂肪酶对妊娠合并重症急性胰腺炎的预判价值

DOI: 10.3969/j.issn.1001-5256.2016.10.024

黎先萍,
李娟

农垦三亚医院妇产科

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中图分类号: R714.255
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出版历程
- 出版日期: 2016-10-20

Clinical value of serum C-reactive protein,procalcitonin,and lipase in predicting severe acute pancreatitis during pregnancy

Department of Obstetrics and Gynecology, Nongken Sanya Hospital

摘要

摘要:
目的探讨血清CRP、降钙素原（PCT）及脂肪酶检测对妊娠合并重症急性胰腺炎（SAP）的临床预判价值。方法回顾性分析农垦三亚医院2011年1月-2016年1月收治的126例妊娠合并急性胰腺炎（AP）患者的临床资料。根据AP的严重程度,分为妊娠合并轻中型AP组（对照组,71例）和妊娠合并SAP组（观察组,55例）。比较2组患者妊娠期AP的临床特点,观察静脉血WBC计数、Hb、血浆Alb、血淀粉酶、CRP、PCT和脂肪酶等实验室指标。计量资料2组间比较采用t检验,计数资料2组间比较采用χ2检验,选取有统计学意义的指标构建受试者工作特征曲线（ROC曲线）,评价其敏感度和特异度。结果观察组血脂肪酶、PCT及CRP分别为（857.73±158.61）U/L、（10.07±4.55）ng/ml、（269.93±63.61）mg/L,明显高于对照组（590.19±138.67）U/L、（5.89±2.13）ng/ml、（202.64±39.58）mg/L（χ2值分别为7.689、15.492、7.500,P值均<0.01）。ROC曲线分析显示,血脂肪酶、PCT及CRP对应曲线下面积分别为0.92...
- 胰腺炎,急性坏死性 /
- 妊娠 /
- C反应蛋白质 /
- 降钙素原 /
- 脂肪酶
Abstract:
Objective To investigate clinical value of serum C-reactive protein( CRP),procalcitonin( PCT),and lipase in predicting severe acute pancreatitis( SAP) during pregnancy. Methods A retrospective analysis was performed for the clinical data of 126 pregnant women with acute pancreatitis( AP) who were treated in Nongken Sanya Hospital from January 2011 to January 2016. According to the severity of AP,the patients were divided into control group( pregnancy complicated by mild-to-moderate AP,71 patients) and observation group( pregnancy complicated by SAP,55 patients). The clinical features of AP in pregnancy were compared between the two groups. The laboratory markers including venous leukocyte count,hemoglobin,plasma albumin,blood amylase,CRP,PCT,and lipase were observed. The t-test was used for comparision of continuos data between groups,and the chi-square test was used for comparision of categorial data between groups,and the receiver operating characteristic( ROC) curves were plotted for statistically significant markers to assess their sensitivities and specificities. Results The observation group had significantly higher serum levels of lipase,PCT,and CRP than the control group( lipase: 857. 73 ± 158. 61 U / L vs 590. 19 ±138. 67 U / L,χ~2= 7. 689,P < 0. 01; PCT: 10. 07 ± 4. 55 ng / ml vs 5. 89 ± 2. 13 ng / ml,χ~2= 15. 492,P < 0. 01; CRP: 269. 93 ± 63. 61 mg / L vs 202. 64 ± 39. 58 mg / L,χ~2= 7. 500,P < 0. 01). According to the ROC curves,serum lipase,PCT,and CRP had areas under the ROC curve of 0. 920,0. 841,and 0. 832,respectively,with corresponding cut-off values of 712 U / L,7. 6 ng / ml,and 262. 0 mg / L,sensitivities of 87.9%,83. 5%,and 81. 3%,and specificities of 83. 2%,86. 1%,and 78. 9%,respectively. Conclusion Increased serum levels of lipase,PCT,and CRP have a great value in the diagnosis of SAP during pregnancy.
- pancreatitis /
- acute necrotizing /
- pregnancy /
- C-reactive protein /
- procalcitonin

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