儿童常见慢性肝病的治疗与随访

吕欣桐; 朱忠生; 王朝霞

doi:10.3969/j.issn.1001-5256.2017.10.013

儿童常见慢性肝病的治疗与随访

DOI: 10.3969/j.issn.1001-5256.2017.10.013

1. 吉林大学第一医院小儿消化科
2. 深圳市儿童医院消化科

详细信息

中图分类号: R725.7
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出版历程
- 收稿日期: 2017-09-01
- 出版日期: 2017-10-20

Treatment and follow-up of children with common chronic liver diseases in children

Department of Pediatric Gastroenterology, First Hospital, Jilin University

摘要

摘要:
儿童慢性肝病严重影响儿童生长发育、未来生存质量,而引起儿童慢性肝病的原因很多,不同病因、饮食及治疗指导与预后密切相关。对较常见的儿童慢性肝病,如婴儿胆汁淤积性肝病、慢性乙型肝炎、肝豆状核变性、非酒精性脂肪性肝病等的指导与随访进行论述,加强慢性肝病患者对疾病的认识,增强医务工作者对随访工作的意识,提高不同病因所致肝病的治愈率及患儿生存质量。
- 肝疾病 /
- 营养疗法 /
- 随访研究 /
- 儿童
Abstract:
Chronic liver diseases in children greatly affect their growth and development and quality of life in future. There are many causes of chronic liver diseases in children, and such causes, diet, and treatment guidance are closely associated with prognosis. This article discusses the guidance and follow-up of common chronic liver diseases in children, such as infantile cholestatic liver disease, chronic hepatitis B, hepatolenticular degeneration, and nonalcoholic fatter liver disease, in order to deepen the understanding of these diseases among patients, raise the awareness of follow-up in medical staff, and improve the cure rate of liver diseases with different causes and children's quality of life.
- liver diseases /
- nutrition therapy /
- follow-up studies /
- child

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参考文献(26)

[1]LI ZL.Therapy of infantile cholestatic hepatopathy[J].J Appl Clin Pediatr, 2012, 27 (7) :476-478. (in Chinese) 李在玲.婴儿胆汁淤积性肝病的治疗[J].实用儿科临床杂志, 2012, 27 (7) :476-478.

[2]LIAO Q, WAN CM, ZHU Y, et al, Current status of research on infantile cholestatic liver disease in China:a visualization analysis[J].Chin J Contemp Pediatr, 2017, 19 (5) :529-533. (in Chinese) 廖琼, 万朝敏, 朱渝, 等.婴儿胆汁淤积性肝病在中国的研究现状的可视化分析[J].中国当代儿科杂志, 2017, 19 (5) :529-533.

[3]CATZOLA A, VAJRO P.Management options for cholestatic liver disease in children[J].Expert Rev Gastroenterol Hepatol, 2017.[Epub ahead of print]

[4]HUANG ZH, LI XS.The nutritional therapy of cholestatic liver disease in infants[J].J Clin Pediatr, 2013, 31 (10) :901-904. (in Chinese) 黄志华, 李雪松.婴儿胆汁淤积性肝病的营养治疗[J].临床儿科杂志, 2013, 31 (10) :901-904.

[5]DEIRDRE KELLY.Pediatric gastrointestinal and liver disease[M]//WYLLIE R, HYAMS JS, KAY M.Pediatric gastrointestinal and liver disease.4th ed.Philadelphia, Saunders, 2011:840-852.

[6]WANG G, FENG D.Dynamic relationship between infantile hepatitis syndrome and cytomegalovirus infection[J].Exp Ther Med, 2017, 13 (6) :3443-3447.

[7] XIAO CX, LI ZY.Clinical analysis and follow-up of neonatal intrahepatic cholestasis caused by Citrin deficiency in 29 children[J].J Appl Clin Pediatr, 2016, 31 (7) :518-521. (in Chinese) 肖长雪, 李中跃.Citrin缺陷致新生儿肝内胆汁淤积症29例临床分析及疗效观察[J].中华实用儿科临床杂志, 2016, 31 (7) :518-521.

[8]STAPLETON C, BOULTER E, BALASUBRAMANIAM S.Citrin deficiency:a rare but important metabolic disorder to consider in infants with faltering growth and hyperbilirubinaemia[J].J Paediatr Child Health, 2017.[Epub ahead of print]

[9]BISWAS S, PAUL N, DAS SK.Nonmotor manifestations of Wilson's disease[J].Int Rev Neurobiol, 2017, 134:1443-1459.

[10]ALA A, WALKER AP, ASHKAN K, et al.Wilson's disease[J].Lancet, 2007, 369:397-408.

[11]LU Y, WANG JS.Diagnosis of Wilson's disease in children[J].JClin Hepatol, 2012, 28 (12) :907-910. (in Chinese) 陆怡, 王建设.儿童肝豆状核变性的诊断[J].临床肝胆病杂志, 2012, 28 (12) :907-910.

[12]European Association for Study of Liver.EASL clinical practice guidelines:Wilson's disease[J].J Hepatol, 2012, 56 (3) :671-685.

[13]YANG X.Update on diagnosis and treatment of Wilson disease in China[J].J Clin Hepatol, 2013, 29 (11) :905-908. (in Chinese) 杨旭.更新观念, 提高我国肝豆状核变性诊治的临床水平[J].临床肝胆病杂志, 2013, 29 (11) :905-908.

[14]MURA G, ZIMBREAN PC, DEMELIA L, et al.Psychiatric comorbidity in Wilson's disease[J].Int Rev Psychiatry, 2017.[Epub ahead of print]

[15]Group of Fatty Liver and Alcoholic Liver Diseases, Society of Hepatology, Chinese Medical Association.Guidelines for Management of non-alcoholic fatty liver disease[J].J Clin Hepatol, 2010, 26 (2) :120-124. (in Chinese) 中华医学会肝脏病学分会脂肪肝和酒精性肝病学组.非酒精性脂肪性肝病诊疗指南[J].临床肝胆病杂志, 2010, 26 (2) :120-124.

[16]DOULBERIS M, KOTRONIS G, GIALAMPRINOU D, et al.Non-alcoholic fatter liver disease:an update with special focus on the role of gut microbiota[J].Matabolism, 2017, 71:182-197.

[17]WAN YP, CHEN ZQ, WU YJ, et al.The comprehansive treatment outcome of fatty liver in children with simple obesity[J].J Clin Pediatr, 2003, 21 (7) :428-430. (in Chinese) 万燕平, 陈之琦, 吴颖洁, 等.儿童单纯性肥胖病伴脂肪肝综合治疗后转归[J].临床儿科杂志, 2003, 21 (7) :428-430.

[18]HUANG XY, ZHANG QZ.An excerpt of NASPGHAN clinical practice guideline for the diagnosis and treatment of nonalcoholic fatty liver disease in children[J].J Clin Hepatol, 2017, 33 (4) :638-642. (in Chinese) 黄鑫禹, 张秋瓒.《2016年北美儿童胃肠病肝病营养学会临床实践指南:儿童脂肪性肝病的诊断治疗》摘译[J].临床肝胆病杂志, 2017, 33 (4) :638-642.

[19]LIANG L, FU JF.Nonalcoholic steatohepatitis in children with obese[J].J Appl Clin Pediatr, 2008, 23 (8) :568-570. (in Chinese) 梁黎, 傅君芬.肥胖儿童非酒精性脂肪性肝炎[J].实用儿科临床杂志, 2008, 23 (8) :568-570.

[20]SELVAKUMAR PKC, KABBAW MN, NOBILI V, et al.Nonalcoholic fatter liver disease in children:hepatic and extrahepatic complications[J].Pediatr Clin North Am, 2017, 64 (3) :659-675.

[21]Chinese Society of Hepatology and Chinese Society of Infectious Diseases, Chinese Medical Association.The guideline of prevention andtreatment for chronic hepatitis B:a 2015 update[J].J Clin Hepatol, 2015, 31 (12) :1941-1960. (in Chinese) 中华医学会肝病学分会, 中华医学会感染病学分会.慢性乙型肝炎防治指南 (2015年更新版) [J].临床肝胆病杂志, 2015, 31 (12) :1941-1960.

[22]European Association for the Study of the Liver.EASL clinical practice guidelines:management of chronic hepatitis B virus infection[J].J Hepatol, 2012, 57 (1) :167-185.

[23]JONAS MM, BLOCK JM, HABER BA, et al.Treatment of children with chronic hepatitis B virus infection in the United States:patient selection and therapeutic options[J].Hepatology, 2010, 52 (6) :2192-2205.

[24]SOKAL EM, PAGANELLI M, WIRTH S, et al.Management of chronic hepatitis B in childhood:ESPGHAN clinical practice guidelines consensus of an expert panel on behalf of the European Society of Pediatric Gastroenterology, Hepatology and Nutrition[J].J Hepatol, 2013, 59 (4) :814-829.

[25]YU YC, HOU JL.The highlights of EASL 2017 clinical practice guidelines on the management of hepatitis B virus infection[J].JClin Hepatol, 2017, 33 (6) :1017-1032. (in Chinese) 于乐成, 侯金林.2017年欧洲肝病学会临床实践指南:HBV感染的管理 (精粹) [J].临床肝胆病杂志, 2017, 33 (6) :1017-1032.

[26]GAO QJ, XIE JX, WANG LM, et al.Interaction effects among IFN-γ+874, IL-2-330, IL-10-1082, IL-10-592 and IL-4-589 polymorphisms on the clinical progression of subjects infected with hepatitis B virus and/or hepatitis C virus:a retrospective nested case-control study[J].BMJ Open, 2017, 7 (8) :e013279.

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