microRNA在慢性乙型肝炎肝纤维化中的诊断价值

李萍英; 杨永耿; 陆伦根; 朱智勇; 王亚平; 马颖才

doi:10.3969/j.issn.1001-5256.2017.12.036

microRNA在慢性乙型肝炎肝纤维化中的诊断价值

DOI: 10.3969/j.issn.1001-5256.2017.12.036

1. 青海大学
2. 青海省人民医院消化科
3. 上海交通大学附属第一人民医院消化科

基金项目:

中国肝炎防治基金会天晴肝病基金项目(TQGB20140260)；

详细信息

中图分类号: R512.62;R575.2
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出版历程
- 收稿日期: 2017-06-21
- 出版日期: 2017-12-20

Value of microRNAs in diagnosis of chronic hepatitis B-related liver fibrosis

Qinghai University

Research funding:

摘要

摘要: 寻找能够准确识别慢性乙型肝炎（CHB）肝纤维化的血清标志物十分重要。归纳了在CHB肝纤维化过程中存在表达差异的microRNA（miRNA）,分析表明随着肝纤维化发展,血清miR-33a、miR-185、miR-222等表达量升高,而血清miR-122、miR-29、miR-27b等表达量下降。发现血清miR-185、miR-122等miRNA单独或联合其他指标在诊断CHB肝纤维化中已具有一定的临床应用价值。认为应进一步加大对存在差异表达的具有诊断CHB肝纤维化价值的血清miRNA的研究。
- 肝炎,乙型,慢性 /
- 微RNAs /
- 肝硬化 /
- 综述
Abstract: It is very important to find suitable serum markers which can accurately identify chronic hepatitis B ( CHB) -related liver fibrosis. This article summarizes the differentially expressed serum microRNAs ( miRNAs) in the process of CHB-related liver fibrosis. The analysis shows that with the development of liver fibrosis, there are increases in the serum levels of miR-33 a, miR-185, and miR-222 and reductions in the serum levels of miR-122, miR-29, and miR-27 b. It has been found that miRNAs such as miR-185 and miR-122 measured alone or in combination with other indices have a certain clinical value in the diagnosis of CHB-related liver fibrosis. It is pointed out that further research should be conducted for differentially expressed serum miRNAs which have a certain value in the diagnosis of CHB-related liver fibrosis.
- hepatitis B, chronic /
- microRNAs /
- liver cirrhosis /
- review

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参考文献(32)

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