Abstract: Objective To investigate the clinical effect and safety of selective transcatheter arterial embolization ( TAE) combined with CT-guided microwave ablation in the treatment of hepatic hemangioma, and to provide a reference for the selection of treatment methods for hepatic hemangioma. Methods A retrospective analysis was performed for the clinical data of 29 patients with hepatic hemangioma who underwent selective TAE combined with CT-guided microwave ablation in Beijing You An hospital from January 2012 to December 2016. The complications of ablation, complete ablation rate, change in the size of hemangioma, and improvement in clinical symptoms were observed to evaluate the clinical effect and safety of this treatment regimen. The t-test was used for the comparison of continuous data between groups.Results A total of 29 patients with 31 lesions of hepatic hemangioma were treated. Eleven patients experienced the complications of ablation, among whom two experienced pyrexia alone, three experienced abdominal pain, two experienced pyrexia and abdominal pain, two experienced hemoglobinuria alone, one experienced hemoglobinuria and slight subcapsular bleeding, and one experienced bile tumor and abdominal pain, and these patients were cured after symptomatic treatment. The incidence rate of complications was 37. 93% ( 11/29) , and no patient experienced severe complications or death. The patients were followed up till three months after surgery, and the clinical symptoms completely disappeared after ablation. According to the results of contrast-enhanced computed tomography or magnetic resonance imaging, there was a significant reduction in the mean diameter of the 31 hepatic hemangiomas after surgery ( 4. 44 ± 1. 39 cm vs 6. 58 ± 1. 25 cm, t =14. 02, P < 0. 01) , and the mean residual rate of the lesions of hepatic hemangioma was ( 66. 6 ± 12. 5) %. Of all patients, 27 ( 93. 1%) achieved complete ablation and 2 ( 6. 9%) had incomplete ablation, and since these two patients had complete remission of clinical symptoms and follow-up at 6 months after surgery showed no progressive enlargement of hepatic hemangioma, ablation was not performed again. Conclusion Selective TAE combined with CT-guided microwave ablation has a good clinical effect and high safety in the treatment of hepatic hemangioma, and therefore, it is a minimally invasive surgery holding promise for clinical application.