慢性乙型肝炎合并非酒精性脂肪性肝病的临床研究进展

曹丹; 陈文静; 李艳平; 陈延平

doi:10.3969/j.issn.1001-5256.2018.09.033

慢性乙型肝炎合并非酒精性脂肪性肝病的临床研究进展

DOI: 10.3969/j.issn.1001-5256.2018.09.033

延安大学附属医院感染病科

基金项目:

陕西省重点研发计划项目(2017SF-269)；延安市科技创新团队建设项目(2017C×TD-02)；

详细信息

中图分类号: R575.5;R512.62
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出版历程
- 收稿日期: 2018-03-22
- 出版日期: 2018-09-20

Research advances in chronic hepatitis B complicated by nonalcoholic fatty liver disease

Department of Infectious Diseases, Yan'an University Affiliated Hospital

Research funding:

摘要

摘要: 非酒精性脂肪性肝病(NAFLD)已成为全球第一大慢性肝病,慢性乙型肝炎(CHB)合并NAFLD也越来越常见,逐渐受到临床医师的重视。目前对CHB合并NAFLD的临床特征及预后尚未形成明确认识。通过对CHB合并NAFLD相关文献的归纳,综述了该病发生的危险因素和生化学、病毒学、组织学以及预后等方面的临床研究进展。认为年龄、男性及代谢紊乱是CHB患者发生NAFLD的危险因素;CHB合并NAFLD患者肝硬化及肝细胞癌的发生风险增加。但目前关于NAFLD对CHB患者病毒复制及清除的影响及其机制、HBV感染对NAFLD发生的影响尚不清楚,这将成为今后的研究热点。
- 肝炎,乙型,慢性 /
- 非酒精性脂肪性肝病 /
- 综述
Abstract: Nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease around the world, and chronic hepatitis B (CHB) complicated by NAFLD has also become more and more common and is taken seriously by clinical physicians. At present, there is no clear understanding of the clinical features and prognosis of CHB complicated by NAFLD. With reference to related literature on CHB complicated by NAFLD, this article reviews the research advances in the risk factors, biochemistry, virology, histology, and prognosis of CHB complicated by NAFLD. It is pointed out that age, male sex, and metabolic disorders are the risk factors for NAFLD in CHB patients, and patients with CHB complicated by NAFLD have a high risk of liver cirrhosis and hepatocellular carcinoma. However, the effect and mechanism of NAFLD on virus replication and clearance in CHB patients and the effect of HBV infection on the development of NAFLD remain unclear, which will be research hotspots in future.
- hepatitis B, chronic /
- non-alcoholic fatty liver disease /
- review

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参考文献(36)

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