Objective To investigate the clinical features of cholestatic liver disease ( CLD) , and to provide a reference for strengthening the diagnosis and treatment of this disease. Methods A retrospective analysis was performed for the clinical data of 107 patients who were admitted to Chenggong Hospital Affiliated to Xiamen University from January 2015 to December 2017 and were diagnosed with CLD. The t-test was used for comparison of continuous data between groups. Results Most patients had the clinical symptoms of weakness, loss of appetite, nausea, abdominal distension, pruritus, and jaundice. According to the site of cholestasis, there were 64 patients ( 59. 8%) with intrahepatic cholestasis and 43 ( 40. 2%) with extrahepatic cholestasis. The cause of the disease was common bile duct stones in 21 patients ( 19. 6%) , bile duct parasites in 1 patient ( 0. 9%) , primary sclerosing cholangitis in 2 patients ( 1. 9%) , primary biliary cirrhosis in 3 patients ( 2. 8%) , liver cancer in 8 patients ( 7. 5%) , bile duct carcinoma in 5 patients ( 4. 7%) , pancreatic cancer in 4 patients ( 3. 7%) , pancreatitis in 12 patients ( 11. 2%) , viral hepatitis in 28 patients ( 26. 2%) , drug-induced liver injury in 11 patients ( 10. 3%) , alcoholic hepatitis in 6 patients ( 5. 6%) , nonalcoholic fatty liver disease in 4 patients ( 3. 7%) , and autoimmune hepatitis in 2 patients ( 1. 9%) . The CLD patients with underlying diseases had a significantly poorer liver function ( alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transpeptidase, alkaline phosphatase, bile acid, and total bilirubin) than those with CLD alone ( t =-3. 44, -2. 99, -2. 42, -4. 39, -3. 34, and-2. 49, all P < 0. 05) . Most of the patients achieved good recovery after liver-protecting, transaminase-lowering, and jaundice clearance treatment. The patients with tumors had poor prognosis. Conclusion CLD has various causes, and its clinical features lack specificity. Clinicians should pay enough attention to this disease.