肝癌局部消融治疗引起的热休克蛋白70增强免疫研究进展

塔来提·吐尔干; 吐尔干艾力·阿吉

doi:10.3969/j.issn.1001-5256.2018.11.038

肝癌局部消融治疗引起的热休克蛋白70增强免疫研究进展

DOI: 10.3969/j.issn.1001-5256.2018.11.038

新疆医科大学第一附属医院肝胆包虫科

基金项目:

传染病防治国家科技重大专项(2018ZX10301201)；

详细信息

中图分类号: R735.7
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出版历程
- 出版日期: 2018-11-20

Research advances in immune enhancement by heat shock protein 70 induced by local ablation for liver cancer

Research funding:

摘要

摘要: 肝癌仍严重威胁人类健康,探索治疗肝癌的新型微创方法迫在眉睫。系统回顾了肝癌在我国的一般情况,叙述了肝癌目前的局部消融及免疫治疗方法。介绍了纳秒脉冲治疗肝癌的基本原理和热休克蛋白70在抗肿瘤免疫中的作用机制。提出纳秒脉冲作为一种外源性电刺激会使机体中的热休克蛋白7表达升高,来加强机体的抗肿瘤免疫。完善了纳秒脉冲治疗肝癌的免疫学机制,并为肝癌的免疫治疗提供了新思路。
- 肝肿瘤 /
- HSP70热休克蛋白质类 /
- 导管消融术 /
- 综述
Abstract: Liver cancer still threatens human health nowadays, so it is urgent to explore new minimally invasive methods for the treatment of liver cancer. This article reviews the general status of liver cancer in China and describes local ablation and immunotherapy for liver cancer.This article also introduces the basic principle of nanosecond pulse in the treatment of liver cancer and the mechanism of action of heat shock protein 70 ( HSP70) in antitumor immunity and points out that as an exogenous electrical stimulation, nanosecond pulse can increase the expression of HSP70 in the body to strengthen the body's anti-tumor immunity. This article perfects the immunological mechanism of nanosecond pulse in the treatment of liver cancer and provides new thoughts for immunotherapy for liver cancer.
- liver neoplasms /
- HSP70 heat-shock proteins /
- catheter ablation /
- review

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参考文献(48)

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