胰腺癌与细胞自噬、神经浸润的关系

杨延辉; 张玉祥; 桂洋; 刘伟峰; 杨天保; 张彦涛; 和少杰; 孙君军; 范华

doi:10.3969/j.issn.1001-5256.2018.11.045

胰腺癌与细胞自噬、神经浸润的关系

DOI: 10.3969/j.issn.1001-5256.2018.11.045

1. 河南科技大学第一附属医院肝胆外科
2. 河南科技大学第一附属医院泌尿外科
3. 河南科技大学临床医学院

基金项目:

国家自然科学基金河南人才培养联合基金(U1504808)；

详细信息

中图分类号: R735.9
计量
- 文章访问数: 1805
- HTML全文浏览量: 19
- PDF下载量: 360
- 被引次数: 0
出版历程
- 出版日期: 2018-11-20

Research advances in the role of autophagy and perineural invasion in pancreatic cancer

Research funding:

摘要

摘要: 细胞自噬作为一种双向性的肿瘤调节因子,对胰腺癌发生、发展,乃至治疗过程起着非常重要的作用;而神经浸润作为一种特殊的肿瘤转移通路,在胰腺癌中的发生率极高,与胰腺癌手术后高复发率和胰腺癌相关疼痛密切相关。简述了胰腺癌细胞自噬与神经浸润的研究进展,以期对胰腺癌的诊断和治疗提供新的研究思路。
- 胰腺肿瘤 /
- 自噬 /
- 神经浸润 /
- 综述
Abstract: As a bi-directional tumor regulatory factor, autophagy plays an important role in the development, progression, and treatment of pancreatic cancer. Perineural invasion, a special pathway for tumor metastasis, has a high incidence rate in pancreatic cancer and is closely associated with high recurrence rate after pancreatic cancer surgery and pancreatic cancer-related pain. This article summarizes the research advances in the role of autophagy and perineural invasion in pancreatic cancer, so as to provide new research ideas for the diagnosis and treatment of pancreatic cancer.
- pancreatic neoplasms /
- autophagy /
- perineural invasion /
- review

HTML全文

参考文献(48)

[1]KAMISAWA T, WOOD LD, ITOI T, et al.Pancreatic cancer[J].Lancet, 2016, 388 (10039) :73-85.

[2]ZHAO H, XU YH.Young people to the diagnosis and treatment of16 cases of pancreatic tumors[J].Chin J Med Offic, 2016, 44 (7) :709-711. (in Chinese) 赵航, 许元鸿.青年胰腺肿瘤16例临床诊治体会[J].临床军医杂志, 2016, 44 (7) :709-711.

[3]SIEGEL R, MILLER K, JEMAL A.Cancer statistics[J].CACancer J Clin, 2018, 68 (1) :7-30.

[4]ALLEMANI C, MATSUDA T, DI C, et al.Global surveillance of trends in cancer survival 2000-14 (CONCORD-3) :Analysis of individual records for 37 513 025 patients diagnosed with one of 18cancers from 322 population-based registries in 71 countries[J].Lancet, 2018, 391 (10125) :1023-1075.

[5]LI XC, TU JK, GONG JP.Association between oxidative stress and pancreatic cancer[J].J Clin Hepatol, 2017, 33 (10) :2035-2038. (in Chinese) 李小成, 涂经楷, 龚建平.氧化应激与胰腺癌的关系[J].临床肝胆病杂志, 2017, 33 (10) :2035-2038.

[6]CHEN W, ZHENG R, BAADE P, et al.Cancer statistics in China2015[J].CA Cancer J Clin, 2016, 66 (2) :115-132.

[7]GALLUZZI L, BRAVO-SAN P, LEVINE B, et al.Pharmacological modulation of autophagy:Therapeutic potential and persisting obstacles[J].Nat Rev Drug Discov, 2017, 16 (7) :487-511.

[8]SHARIFI MN, MOWERS EE, DRAKE LE, et al.Autophagy promotes focal adhesion disassembly and cell motility of metastatic tumor cells through the direct interaction of paxillin with LC3[J].Cell Rep, 2016, 15 (8) :1660-1672.

[9]XU Z, KLIONSKY DJ.Autophagy promotes cell motility by driving focal adhesion turnover[J].Autophagy, 2016, 12 (10) :1685-1686.

[10]MAERTIN S, ELPERIN JM, LOTSHAW E, et al.Roles of autophagy and metabolism in pancreatic cancer cell adaptation to environmental challenges[J].Am J Physiol Gastrointest Liver Physiol, 2017, 313 (5) :G524-G536.

[11]PERERA RM, STOYKOVA S, NICOLAY BN, et al.Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism[J].Nature, 2015, 524 (7565) :361-365.

[12]HARRIS AL.Hypoxia-a key regulatory factor in tumour growth[J].Nat Rev Cancer, 2002, 2 (1) :38-47.

[13]VAUPEL P, THEWS O, HOECKEL M.Treatment resistance of solid tumors:Role of hypoxia and anemia[J].Med Oncol, 2001, 18 (4) :243-259.

[14]GU Y, QI C, SUN X, et al.Arctigenin preferentially induces tumor cell death under glucose deprivation by inhibiting cellular energy metabolism[J].Biochem Pharmacol, 2012, 84 (4) :468-476.

[15]YANG S, WANG X, CONTINO G, et al.Pancreatic cancers require autophagy for tumor growth[J].Genes Dev, 2011, 25 (7) :717-729.

[16]TULOUP-MINGUEZ V, GREFFARD A, CODOGNO P, et al.Regulation of autophagy by extracellular matrix glycoproteins in HeLa cells[J].Autophagy, 2011, 7 (1) :27-39.

[17]LOCK R, DEBNATH J.Extracellular matrix regulation of autophagy[J].Curr Opin Cell Biol, 2008, 20 (5) :583-588.

[18]XU Y, DAI SL.Research advances in molecular targeted therapy for pancreatic cancer[J].Chin J Clin Hepatol, 2016, 32 (10) :2026-2028. (in Chinese) 许莹, 戴树龙.胰腺癌分子靶向治疗的研究进展[J].临床肝胆病杂志, 2016, 32 (10) :2026-2028.

[19]ROSENFELDT MT, O'PREY J, MORTON JP, et al.p53 status determines the role of autophagy in pancreatic tumour development[J].Nature, 2013, 504 (7479) :296-300.

[20]SCHMUKLER E, KLOOG Y, PINKAS-KRAMARSKI R.Ras and autophagy in cancer development and therapy[J].Oncotarget, 2014, 5:577-586

[21]KANG R, TANG D, SCHAPIRO NE, et al.The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival[J].Cell Death Differ, 2010, 17 (4) :666-676.

[22]KIM KH, LEE MS.Autophagy as a crosstalk mediator of metabolic organs in regulation of energy metabolism[J].Rev Endocr Metab Disord, 2014, 15 (1) :11-20.

[23]DEMIR IE, CEYHAN GO, LIEBL F, et al.Neural invasion in pancreatic cancer:The past, present and future[J].Cancers (Basel) , 2010, 2 (3) :1513-1527.

[24]LIEBIG C, AYALA G, WILKS JA, et al.Perineural invasion in cancer:A review of the literature[J].Cancer, 2009, 115 (15) :3379-3391.

[25]GUO K, MA Q, LI J, et al.Interaction of the sympathetic nerve with pancreatic cancer cells promotes perineural invasion through the activation of STAT3 signaling[J].Mol Cancer Ther, 2013, 12 (3) :264-273.

[26]MAKINO I, KITAGAWA H, OHTA T, et al.Nerve plexus invasion in pancreatic cancer:Spread patterns on histopathologic and embryological analyses[J].Pancreas, 2008, 37 (4) :358-365.

[27]DESHMUKH SD, WILLMANN JK, JEFFREY RB.Pathways of extrapancreatic perineural invasion by pancreatic adenocarcinoma:E-valuation with 3D volume-rendered MDCT imaging[J].AJR Am JRoentgenol, 2010, 194 (3) :668-674.

[28]SAHIN IH, SHAMA MA, TANAKA M, et al.Association of diabetes and perineural invasion in pancreatic cancer[J].Cancer Med, 2012, 1 (3) :357-362.

[29]LI J, MA J, HAN L, et al.Hyperglycemic tumor microenvironment induces perineural invasion in pancreatic cancer[J].Cancer Biol T-her, 2015, 16 (6) :912-921.

[30]SCIACCA L, VIGNERI R, TUMMINIA A, et al.Clinical and molecular mechanisms favoring cancer initiation and progression in diabetic patients[J].Nutr Metab Cardiovasc Dis, 2013, 23 (9) :808-815.

[31]RYU TY, PARK J, SCHERER PE.Hyperglycemia as a risk factor for cancer progression[J].Diabetes Metab J, 2014, 38 (5) :330-336.

[32]CELESTI G, DI CG, BIANCHI P, et al.Early expression of the fractalkine receptor CX3CR1 in pancreatic carcinogenesis[J].Br JCancer, 2013, 109 (9) :2424-2433.

[33]XU X, WANG Y, CHEN J, et al.High expression of CX3CL1/CX3CR1 axis predicts a poor prognosis of pancreatic ductal adenocarcinoma[J].J Gastrointest Surg, 2012, 16 (8) :1493-1498.

[34]BAPAT AA, HOSTETTER G, von HOFF DD, et al.Perineural invasion and associated pain in pancreatic cancer[J].Nat Rev Cancer, 2011, 11 (10) :695-707.

[35]ZHU Y, COLAK T, SHENOY M, et al.Nerve growth factor modulates TRPV1 expression and function and mediates pain in chronic pancreatitis[J].Gastroenterology, 2011, 141 (1) :370-377.

[36]TIEFTRUNK E, DEMIR IE, FRIESS H, et al.Back pain as a potential indicator of local recurrence in pancreatic cancer[J].J Surg Case Rep, 2015, 2015 (10) :rjv127.

[37]DANIGO A, MAGY L, DEMIOT C.TRPV1 in neuropathic pain:from animal models to therapeutical prospects[J].Med Sci (Paris) , 2013, 29 (6-7) :597-606.

[38]CHATZISTEFANOU I, LUBEK J, MARKOU K, et al.The role of perineural invasion in treatment decisions for oral cancer patients:Areview of the literature[J].J Craniomaxillofac Surg, 2017, 45 (6) :821-825.

[39]ZHANG JF, HUA R, LIU DJ, et al.Effect of CD74 on the prognosis of patients with resectable pancreatic cancer[J].Hepatobiliary Pancreat Dis Int, 2014, 13 (1) :81-86.

[40]NAGATA S, JIN YF, YOSHIZATO K, et al.CD74 is a novel prognostic factor for patients with pancreatic cancer receiving multimodal therapy[J].Ann Surg Oncol, 2009, 16 (9) :2531-2538.

[41]KUSHIRO K, CHU RA, VERMA A, et al.Adipocytes promote B16BL6 melanoma cell invasion and the epithelial-to-mesenchymal transition[J].Cancer Microenviron, 2012, 5 (1) :73-82.

[42]HIBI T, MORI T, FUKUMA M, et al.Synuclein-gamma is closely involved in perineural invasion and distant metastasis in mouse models and is a novel prognostic factor in pancreatic cancer[J].Clin Cancer Res, 2009, 15 (8) :2864-2871.

[43]BRADSHAW RA, PUNDAVELA J, BIARC J, et al.NGF and ProNGF:Regulation of neuronal and neoplastic responses through receptor signaling[J].Adv Biol Regul, 2015, 58:16-27.

[44]SKAPER SD.Nerve growth factor:A neuroimmune crosstalk mediator for all seasons[J].Immunology, 2017, 151 (1) :1-15.

[45]BLAKE KJ, BARAL P, VOISIN T, et al.Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1that is silenced by QX-314[J].Nat Commun, 2018, 9 (1) :37.

[46]DEMIR IE, FRIESS H, CEYHAN GO.Neural plasticity in pancreatitis and pancreatic cancer.[J].Nat Rev Gastroenterol Hepatol, 2015, 12 (11) :649-659.

[47]YANG S, KIMMELMAN AC.A critical role for autophagy in pancreatic cancer[J].Autophagy, 2011, 7 (8) :912-913.

[48]YANG YH, LIU JB, GUI Y, et al.Relationship between autophagy and perineural invasion, clinicopathological features, and prognosis in pancreatic cancer[J].World J Gastroenterol, 2017, 23 (40) :7232-7241.

施引文献

资源附件(0)

访问统计