HBV相关肝细胞癌的危险因素、早期筛查和预防策略

李汨; 聂青和; 韩曼; 鞠迪

doi:10.3969/j.issn.1001-5256.2019.03.045

HBV相关肝细胞癌的危险因素、早期筛查和预防策略

DOI: 10.3969/j.issn.1001-5256.2019.03.045

1. 陕西中医药大学
2. 空军军医大学唐都医院传染病科全军感染病诊疗中心

基金项目:

陕西中医药大学基础医学院中西医结合基础心血管方向创新团队资助项目；

详细信息

中图分类号: R735.7;R512.62
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- 文章访问数: 1310
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- 被引次数: 0
出版历程
- 收稿日期: 2018-09-10
- 出版日期: 2019-03-20

Risk factors, early screening, and preventing strategy for hepatitis B-related hepatocellular carcinoma

Shaanxi University of Chinese Medicine

Research funding:

摘要

摘要: 肝细胞癌(HCC)是全球癌症死亡的主要原因之一,HBV感染是HCC最重要的危险因素之一。HBV相关HCC的发生是宿主与病毒相互作用的复杂过程,危险因素包括HBV病毒载量、HBeAg、宿主易感性等。HCC筛查方式包括超声等影像学检查和AFP等血清标志物,血清异常凝血酶原Ⅱ和AFP异质体有助于诊断AFP阴性HCC。如果采取接种乙型肝炎疫苗、抗病毒治疗等合理措施,可以预防HCC发生。慢性乙型肝炎抗病毒治疗的长远目标在于减少并发症发生,包括肝硬化甚至HCC。核苷类药物抗病毒治疗可有效抑制病毒复制,但无法根除肝细胞核内的cccDNA,治愈乙型肝炎仍然迫在眉睫。综述了HBV相关HCC的流行病学、危险因素、筛查方法和预防策略。
- 肝炎病毒,乙型 /
- 癌,肝细胞 /
- 危险因素 /
- 综合预防 /
- 综述
Abstract: Hepatocellular carcinoma ( HCC) is a leading cause of cancer-related death worldwide and hepatitis B virus ( HBV) infection isone of most important risk factors for HCC. The development of HBV-related HCC involves a complex interaction between host and virus, and related risk factors include HBV viral load, HBeAg, and host susceptibility. Screening methods for HCC include radiological examina-tion such as ultrasound and serological markers such as α-fetoprotein, and protein induced by vitamin K antagonist-II and alpha-fetopro-tein ( AFP) variants may help with the diagnosis of AFP-negative HCC. Appropriate measures such as HBV vaccination and antiviral thera-py can help to prevent HCC. The long-term goal of antiviral therapy for chronic hepatitis B is to reduce complications such as liver cirrhosisand HCC. nucleos ( t) ide analogues can effectively inhibit replication of virus, but they cannot eradicate covalently closed circular DNA inthe nucleus of hepatocytes. There is still an urgent need for a cure for hepatitis B. This article reviews the epidemiology, risk factors, screening methods, and preventive strategies for HBV-related HCC.
- hepatitis B virus /
- carcinoma, hepatocellular /
- risk factors /
- universal precautions /
- review

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