干扰素治疗B、C基因型慢性乙型肝炎临床效果差异的Meta分析

李敏; 单姗; 吴晓宁; 孔媛媛; 欧晓娟; 尤红; 贾继东

doi:10.3969/j.issn.1001-5256.2019.06.015

干扰素治疗B、C基因型慢性乙型肝炎临床效果差异的Meta分析

DOI: 10.3969/j.issn.1001-5256.2019.06.015

1. 首都医科大学附属北京友谊医院国家消化疾病临床医学研究中心
2. 首都医科大学附属北京友谊医院肝病中心

基金项目:

北京市科委科技计划项目(D161100002716003)；国家科技重大专项“十三五”计划(2018ZX09201016)；

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中图分类号: R512.62
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出版历程
- 收稿日期: 2018-12-17
- 出版日期: 2019-06-20

Clinical effect of interferon in treatment of genotype B or C chronic hepatitis B patients: A meta-analysis

National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University

Research funding:

摘要

摘要: 目的综合评价干扰素治疗B、C基因型慢性乙型肝炎(CHB)患者的疗效差异。方法计算机检索PubMed、Web of Science、The Cochrane Library、CNKI、万方和VIP数据库截止到2018年11月发表的关于干扰素治疗B、C基因型CHB患者疗效差异的文献。2位研究者独立筛选文献、提取资料并评价所纳入文献的质量,然后进行Meta分析。结果共纳入20篇研究文献,Meta分析结果显示,干扰素治疗B基因型CHB患者的HBV DNA阴转率、HBeAg清除率、HBeAg血清学转换率、HBsAg清除率,以及ALT复常率均明显高于C基因型CHB患者(比值比分别为2. 95、3. 16、1. 83、2. 59、2. 31,95%可信区间分别为2. 22～3. 91、2. 38～4. 20、1. 44～2. 33、1. 05～6. 38、1. 69～3. 16,P值均<0. 05)。亚组分析结果显示,干扰素在B、C基因型CHB患者中的疗效差异不受干扰素种类的影响。结论干扰素的抗病毒效果受到HBV基因型的影响,B基因型抗病毒效果优于C基因型,因此,HBV基因型是预测干扰素疗效的...
- 肝炎,乙型,慢性 /
- 基因型 /
- 干扰素类 /
- 治疗结果 /
- Meta分析
Abstract: Objective To investigate the clinical effect of interferon (IFN) in the treatment of genotype B or C chronic hepatitis B (CHB) patients. Methods PubMed, Web of Science, The Cochrane Library, CNKI, Wanfang Data, and VIP were searched for articles on IFN in the treatment of genotype B or C CHB patients published up to November, 2018. Two researchers performed screening, data extraction, and quality assessment of the articles independently, and then a meta-analysis was performed. Results A total of 20 articles were included.The results of the meta-analysis showed that compared with the genotype C CHB patients, the genotype B CHB patients had significantly higher HBV DNA clearance rate (odds ratio [OR]= 2. 95, 95% confidence interval [CI]: 2. 22-3. 91, P < 0. 05) , HBeAg clearance rate (OR = 3. 16, 95% CI: 2. 38-4. 20, P < 0. 05) , HBeAg seroconversion rate (OR = 1. 83, 95% CI: 1. 44-2. 33, P < 0. 05) , HBsAg clearance rate (OR = 2. 59, 95% CI: 1. 05-6. 38, P < 0. 05) , and alanine aminotransferase normalization rate (OR = 2. 31, 95% CI: 1. 69-3. 16, P < 0. 05) . The subgroup analysis showed that the clinical effect of IFN in genotype B or C CHB patients was not affected by the type of IFN. Conclusion The antiviral effect of IFNs is affected by HBV genotype, and the patients with genotype B CHB have a better antiviral outcome than those with genotype C CHB. Therefore, HBV genotype is an important factor for predicting the clinical effect of IFN therapy.
- hepatitis B, chronic /
- genotype /
- interferons /
- treatment outcome /
- Meta-analysis

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