口服中药复方汤剂致慢性药物性肝损伤1例报告

孟存英; 刘佳; 曹丹; 陈文静; 袁贝贝; 东冰; 纪冬; 陈延平

doi:10.3969/j.issn.1001-5256.2019.08.031

口服中药复方汤剂致慢性药物性肝损伤1例报告

DOI: 10.3969/j.issn.1001-5256.2019.08.031

延安大学附属医院
解放军总医院第五医学中心肝病内科

基金项目:

菊梅肝胆病防治能力建设专项基金(2018JM12603003)；延安市肝脏病诊疗科技创新团队项目(2017CXTD-02)；首都临床特色应用研究特色课题(Z181100001718034)；

详细信息

中图分类号: R285.6
计量
- 文章访问数: 1011
- HTML全文浏览量: 22
- PDF下载量: 231
- 被引次数: 0
出版历程
- 出版日期: 2019-08-20

A case of chronic drug-induced liver injury caused by psoralen decoction

Department of Infectious Diseases, YanAn University Affiliated Hospital

Research funding:

摘要

摘要: <正>1病例资料患者女性,43岁,主因"厌油、腹胀10余天,加重伴皮肤双目黄染2 d"于2017年6月10日收住延安大学附属医院。入院前10余天患者因"皮炎"口服10副中药复方汤剂(葛根30 g、乳香9 g、没药9 g、栀子6 g、天花粉30 g、灯心草6 g、薏仁30 g、补骨脂15 g、肉豆蔻15 g、吴茱萸6 g、公英15 g、知母15 g、茯苓30 g、当归15 g、升麻6 g、生地15 g),后出现厌油、腹胀,伴反酸、口苦、恶心,呕吐1次,入院前2 d家人发现其皮肤、双目黄
- 药物性肝损伤 /
- 中草药
- drug-induced liver injury /
- drugs, Chinese herbal

HTML全文

参考文献(17)

[1] BJORNSSON ES, BERGMANN OM, BJORNSSON HK, et al.Incidence, presentation, and outcomes in patients with druginduced liver injury in the general population of Iceland[J].Gastroenterology, 2013, 144 (7) :1419-1425, 1421-1425, e19-e20.

[2] FONTANA RJ, WATKINS PB, BONKOVSKY HL, et al. DrugInduced Liver Injury Network (DILIN) prospective study:Rationale, design and conduct[J]. Drug Saf, 2009, 32 (1) :55-68.

[3] CHALASANI NP, HAYASHI PH, BONKOVSKY HL, et al. ACG Clinical Guideline:The diagnosis and management of idiosyncratic drug-induced liver injury[J]. Am J Gastroenterol, 2014, 109 (7) :950-966, 967.

[4] RANGNEKAR AS, FONTANA RJ. An update on drug induced liver injury[J]. Minerva Gastroenterol Dietol, 2011, 57 (2) :213-229.

[5] SHEN T, LIU YX, SHANG J, et al. Incidence and etiology of drug-induced liver injury in mainland China[J]. Gastroenterology, 2019, 156 (8) :2230-2241.

[6] ANDRADE RJ, LUCENA MI, FERNANDEZ MC, et al. Druginduced liver injury:An analysis of 461 incidences submitted to the Spanish registry over a 10-year period[J]. Gastroenterology, 2005, 129 (2) :512-521.

[7] Drug-induced Liver Disease Study Group, Chinese Society of Hepatology, Chinese Medical Association. Guidelines for the management of drug-induced liver injury[J]. J Clin Hepatol, 2015, 31 (11) :1752-1769. (in Chinese) 中华医学会肝病学分会药物性肝病学组.药物性肝损伤诊治指南[J].临床肝胆病杂志, 2015, 31 (11) :1752-1769.

[8] LIU SJ. Beware of liver damage caused by traditional Chinese medicine[J]. Chin Community J, 2008, 24 (14) :23. (in Chinese) 刘士敬.警惕中药引起的肝损害[J].中国社区医师, 2008, 24 (14) :23.

[9] PALMEIRA CM, ROLO AP. Mitochondrially-mediated toxicity of bile acids[J]. Toxicology, 2004, 203 (1-3) :1-15.

[10] BI YN, LI Z, LU GY, et al. Effects of aqueous extract of psoralen on hepatotoxicity and bile acid transport in mice[J].Drug Eval Res, 2015, 38 (3) :267-270. (in Chinese) 毕亚男, 李震, 卢国彦, 等.补骨脂水提物对小鼠的肝毒性及胆汁酸转运的影响[J].药物评价研究, 2015, 38 (3) :267-270.

[11] HAYASHI PH, BJORNSSON ES. Long-term outcomes after drug-induced liver injury[J]. Curr Hepatol Rep, 2018, 17 (3) :292-299.

[12] MEDINA-CALIZ I, ROBLES-DIAZ M, GARCIA-MUOZ B, et al. Definition and risk factors for chronicity following acute idiosyncratic drug-induced liver injury[J]. J Hepatol, 2016, 65 (3) :532-542.

[13] FONTANA RJ, HAYASHI PH, BARNHART H, et al. Persistent liver biochemistry abnormalities are more common in older patients and those with cholestatic drug induced liver injury[J].Am J Gastroenterol, 2015, 10 (10) :1450-1459.

[14] ZHOU TH, XIE Q. Progress in the study of chronic drug-induced liver injury[J]. Liver, 2018, 23 (9) :825-827. (in Chinese) 周天慧, 谢青.慢性药物性肝损伤研究进展[J].肝脏, 2018, 23 (9) :825-827.

[15] YU YC, MAO YM, CHEN CW, et al. CSH guidelines for the diagnosis and treatment of drug-induced liver injury[J]. Hepatol Int, 2017, 11 (3) :221-241.

[16] HOU JX, BU F, YU YC. Drug re-stimulation test for drug-induced liver injury[J]. Chin Hepatol, 2017, 22 (11) :978-982. (in Chinese) 侯俊兴, 卜凡, 于乐成.药物性肝损伤的药物再刺激试验[J].肝脏, 2017, 22 (11) :978-982.

[17] YU YC, FAN Y, CHEN CW. Diagnosis and treatment of druginduced liver injury[J]. J Clin Hepatol, 2018, 34 (6) :1160-1165. (in Chinese) 于乐成, 范晔, 陈成伟.药物性肝损伤的诊断和治疗[J].临床肝胆病杂志, 2018, 34 (6) :1160-1165.

施引文献

资源附件(0)

访问统计