小檗碱抗肝细胞癌的作用及机制

许笑阳; 王雨露; 平键; 赵长青

doi:10.3969/j.issn.1001-5256.2019.12.034

小檗碱抗肝细胞癌的作用及机制

DOI: 10.3969/j.issn.1001-5256.2019.12.034

1. 上海中医药大学附属曙光医院上海中医药大学肝病研究所
2. 上海中医药大学附属曙光医院上海中医药大学肝病研究所肝肾疾病病证教育部重点实验室上海市中医临床重点实验室国家中医药管理局重点研究室(慢性肝病虚损)

基金项目:

国家自然科学基金项目(81673780)；

详细信息

中图分类号: R735.7
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- 被引次数: 0
出版历程
- 收稿日期: 2019-07-16
- 出版日期: 2019-12-20

Role and mechanism of berberine in treatment of hepatocellular carcinoma

Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine & Institute of Liver Diseases,Shanghai University of Traditional Chinese Medicine

Research funding:

摘要

摘要: 小檗碱主要通过抑制癌细胞增殖、诱导癌细胞死亡、抑制癌细胞的转移和入侵、调控细胞内源致癌基因和抑癌基因的表达、影响细胞癌变相关酶的活性、抗氧化应激作用、纠正糖代谢异常、抑制核因子-κB的活性及其通路发挥抗肿瘤作用。小檗碱在体内、体外试验中都显示出明显改善治疗肝细胞癌的功效,其药理作用广泛,具有多种分子调控机制。阐述了黄连等中药的活性成分小檗碱抗肝细胞癌的作用和相关机制,揭示了小檗碱对肝细胞癌的临床疗效,并提出研发新剂型以提高其生物利用度,从而形成有效的治疗方案供临床应用是今后研究工作的重点。
- 癌,肝细胞 /
- 小檗碱 /
- 抗肿瘤药(中药)
Abstract: A large number of studies have shown that berberine exerts an anti-tumor effect mainly by inhibiting cancer cell proliferation,inducing cancer cell death,inhibiting cancer cell metastasis and invasion,regulating the expression of endogenous oncogenes and tumor suppressor genes,affecting the activity of cancer-related enzymes,exerting an anti-oxidative stress effect,correcting abnormal glucose metabolism,and inhibiting the activity of nuclear factor-kappa B and its pathways. In vivo and in vitro studies have shown than berberine has a marked clinical effect in the treatment of hepatocellular carcinoma with various pharmacological actions and molecular regulatory mechanisms. This article reviews the role and mechanism of berberine,an active component of traditional Chinese medicines including Coptis chinensis,in the treatment of hepatocellular carcinoma and thus reveals the clinical effect of berberine in the treatment of hepatocellular carcinoma. In future,new dosage forms should be developed to improve its bioavailability and form effective therapeutic regimens for clinical application.
- carcinoma,hepatocellular /
- berberine /
- antineoplastic drugs(TCD)

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