康莱特注射液联合经肝动脉化疗栓塞术治疗中晚期肝癌效果的Meta分析

孙冬雪; 杨柱; 龙奉玺; 魏显鳗; 唐东昕

doi:10.3969/j.issn.1001-5256.2020.02.026

康莱特注射液联合经肝动脉化疗栓塞术治疗中晚期肝癌效果的Meta分析

DOI: 10.3969/j.issn.1001-5256.2020.02.026

1. 贵阳中医学院第一临床附属医院
2. 贵州省中医肿瘤传承与科技创新人才基地

基金项目:

国家自然科学基金(81673862,81460697)；中医肿瘤学研究生工作站(黔教研合JYSZ字〔2014〕018)；贵州省教育厅青年人才成长项目(黔教合KY字〔2018〕210)；研究生教育创新计划(YFYYJSCX2018-37,YFYYJSCX2018-04)；

详细信息

中图分类号: R735.7
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出版历程
- 收稿日期: 2019-10-29
- 出版日期: 2020-02-20

Efficacy and safety of Kanglaite injection combined with transarterial chemoembolization in treatment of advanced liver cancer: A Meta-analysis

The First Clinical Affiliated Hospital of Guiyang College of Traditional Chinese Medicine

Research funding:

摘要

摘要:
目的对康莱特注射液(KLT)联合经肝动脉化疗栓塞术(TACE)治疗中晚期肝癌的有效性和安全性进行Meta分析。方法检索中国知网、万方数据库、维普数据库、中国生物医学数据库、PubMed、Cochrane Library、Embase自数据库建立至2019年10月的文献,筛选有关KLT与TACE治疗中晚期肝癌的临床研究,试验组为KLT联合TACE治疗,对照组为单独应用TACE治疗。对纳入的文献提取资料及质量评价,采用Revman5. 3软件进行Meta分析。各研究间的异质性采用χ2检验判断;用比值比(OR)和95%可信区间(95%CI)评价结局指标;采用漏斗图对发表偏倚进行评估。结果纳入16篇符合标准的文献,共1131例患者,其中试验组558例,对照组573例。与对照组相比,试验组可显著提高瘤体治疗有效率(OR=2. 85,95%CI:2. 17～3. 76,P <0. 001),提升疾病控制率(OR=2. 58,95%CI:1. 57～4. 24,P <0. 001),提高生存质量卡氏评分(OR=3. 54,95%CI:2. 48～5. 06,P <0. 001),显...
- 肝肿瘤 /
- 化学栓塞,治疗性 /
- 康莱特注射液 /
- Meta分析(主题)
Abstract:
Objective To investigate the efficacy and safety of Kanglaite injection( KLT) combined with transarterial chemoembolization( TACE) in the treatment of advanced liver cancer through a Meta-analysis. Methods CNKI,Wanfang Data,VIP,CBM,PubMed,Cochrane Library,and Embase were searched for clinical studies on KLT combined with TACE in the treatment of advanced liver cancer published up to October 2019. The patients in the experimental group were given KLT combined with TACE,while those in the control group were given TACE alone. Data extraction and quality assessment were performed for the articles included in the analysis,and RevMan 5. 3 was used for Meta-analysis. The chi-square test was used to evaluate heterogeneity between studies; odds ratio( OR) and 95% confidence interval( CI) were used to evaluate outcome measures; funnel plots were used to evaluate publication bias. Results A total of 16 articles which met the inclusion criteria were included,with a total of 1131 patients( 558 patients in the experimental group and 573 in the control group). Compared with the control group,the experimental group had significant increases in tumor response rate( OR = 2. 85,95% CI:2. 17-3. 76,P < 0. 001),disease control rate( OR = 2. 58,95% CI: 1. 57-4. 24,P < 0. 001),and Karnofsky Performance Scale score for quality of life( OR = 3. 54,95% CI: 2. 48-5. 06,P < 0. 001),as well as significant improvements in clinical symptoms( OR = 3. 71,95% CI: 1. 55-8. 89,P = 0. 003) and alpha-fetoprotein level( OR = 2. 57,95% CI: 1. 41-4. 68,P = 0. 002). In addition,the experimental group had a significantly lower incidence rate of bone marrow suppression than the control group( leukocyte reduction: OR = 0. 39,95% CI: 0. 23-0. 66,P < 0. 001; thrombocytopenia: OR = 0. 22,95% CI: 0. 12-0. 42,P < 0. 001). Conclusion In the treatment of advanced liver cancer,KLT combined with TACE results in a high response rate and good quality of life and can reduce the incidence rate of toxic and side effects including bone marrow suppression due to chemotherapy.
- liver neoplasms /
- chemoembolization,therapeutic /
- Kanglaite injection /
- Meta-analysis as topic

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