长春地区成人血清甲胎蛋白、癌胚抗原参考区间适用性验证

朱学彤; 王凯瑾; 周琪; 许建成

doi:10.3969/j.issn.1001-5256.2020.02.027

长春地区成人血清甲胎蛋白、癌胚抗原参考区间适用性验证

DOI: 10.3969/j.issn.1001-5256.2020.02.027

1. 吉林大学第一医院检验科
2. 吉林大学第一医院新生儿科

基金项目:

吉林省卫生厅重点实验室科研课题(2017J071)；吉林省教育厅“十三五”科学技术项目(JJKH20180214KJ)；

详细信息

中图分类号: R735.7;R730.43
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- 被引次数: 0
出版历程
- 收稿日期: 2019-10-08
- 出版日期: 2020-02-20

Validation of applicability of reference intervals for serum alpha-fetoprotein and carcinoembryonic antigen for adults in Changchun,China

Department of Clinical Laboratory,The First Hospital of Jilin University

Research funding:

摘要

摘要:
目的验证卫生行业标准WS/T 645. 2-2018中血清甲胎蛋白、癌胚抗原参考区间是否适用于长春地区。方法按照WS/T 645. 2-2018参考区间验证方法,入组2016年1月-2019年4月在吉林大学第一医院体检中心体检的20～79岁健康体检者5420例,根据年龄和性别划分为12个亚组,验证各组落入参考区间的检测值是否> 90%,分析血清甲胎蛋白、癌胚抗原随年龄及性别变化趋势。计量资料两组比较采用Mann-Whitney U检验。结果血清甲胎蛋白和癌胚抗原各亚组测量值90%以上落在参考区间内,通过参考区间验证。血清甲胎蛋白在30～39岁存在性别差异（Z=-4. 51,P <0. 05）,血清癌胚抗原在20～29岁、30～39岁、40～49岁、50～59岁、60～69岁均存在性别差异（Z值分别为-13. 45、-18. 15、-17. 34、-10. 82、-3. 65,P值均<0. 05）;血清甲胎蛋白在女性20～69岁随年龄缓慢上升,70～79岁男性及女性均随年龄下降;血清癌胚抗原在女性20～79岁、男性20～79岁随年龄上升,且男性检测值高于女性。结论国家卫...
- 甲胎蛋白类 /
- 癌胚抗原 /
- 年龄分布 /
- 参考值
Abstract:
Objective To investigate whether the reference intervals for serum alpha-fetoprotein( AFP) and carcinoembryonic antigen( CEA) in WS/T 645. 2-2018 are applicable to the adults in Changchun,China. Methods According to the validation method for the reference intervals in WS/T 645. 2-2018,5420 subjects,aged from 20-79 years,who underwent physical examination from January 2016 to April 2019 were enrolled and divided into 12 subgroups based on age and sex. Each subgroup was analyzed in terms of whether more than90% of the measured values fell into the reference intervals,and the changing trend of AFP and CEA with age and sex was analyzed. The Mann-Whitney U test was used for comparison between two groups. Results More than 90% of the measured values of serum AFP and CEA fell into the reference intervals,which passed the validation test. There was a significant difference in serum AFP between male and female subjects aged 30-39 years( Z =-4. 51,P < 0. 05),and there was a significant difference in serum CEA between male and female subjects aged 20-29,30-39,40-49,50-59,and 60-69 years( Z =-13. 45,-18. 15,-17. 34,-10. 82,and-3. 65,all P <0. 05). Serum AFP increased slowly with age in female subjects aged 20-69 years and decreased with age in male and female subjects aged70-79 years. Serum CEA increased with age in male and female subjects aged 20-79 years,and male subjects had a higher measured value than female subjects. Conclusion Reference intervals for serum AFP and CEA in WS/T 645. 2-2018 issued by National Health Commission are applicable to the adults in Changchun.
- alpha-fetoproteins /
- carcinoembryonic antigen /
- age distribution /
- reference values

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参考文献(9)

[1] TIAN Z,ZHANG JH. A threshold analysis of alpha-fetoprotein in diagnosis and screening of hepatocellular carcinoma[J]. J Clin Hepatol,2018,34(11):2352-2355.(in Chinese)田州，张建淮．甲胎蛋白诊断和筛查原发性肝癌的阈值分析[J]．临床肝胆病杂志，2018,34(11):2352-2355.

[2] SHANG YM,CHEN Q,LI XM. The prognostic value analysis of the serum CEA,CA19-9 and CA72-4 to the patients with metastatic rectal cancer after chemotherapy[J]. J Clin Exp Med,2018,17(11):1181-1183.(in Chinese)尚永明，陈群，李新明．血清CEA、CA19-9及CA72-4联合检测预测转移性直肠癌患者化疗后预后的价值分析[J]．临床和实验医学杂志，2018,17(11):1181-1183.

[3] National Health and Health Commission of the people’s Republic of China. Reference intervals for common clinical immunology tests Part 2. Non-book Materials:WS/T 645. 2-2018[S]. Beijing:Standards Press of China,2018.(in Chinese)中华人民共和国国家卫生健康委员会．临床常用免疫学检验项目参考区间:第2部分非书资料:WS/T 645. 2-2018[S]．北京:中国标准出版社，2018.

[4] HOROWITZ GL,ALTAEE S,BOYD JC,et al. Establishing,and verifying reference intervals in the clinical laboratory; approved guideline[S]. CLSI document EP28-A3c Wayne,PA:Clinical and Laboratory Standards Institute,2010:1-20.

[5] WAN XH,SONG X,LIU XW. Analysis of serum AFP,CEA levels from 8828 healthy human in Beijing[J]. Chin J Lab Diag,2012,16(7):1239-1241.(in Chinese)万晓华，宋新，刘向岏．北京地区8828名健康人群血清AFP、CEA水平分析[J]．中国实验诊断学，2012,16(7):1239-1241.

[6] XU G,YE M,FANG GP. Establishment of the reference intervals for alpha-fetoprotein and carcinoembryonic antigen in Xuyi of Jiangsu Province,China[J]. Exp Lab Med,2015,33(1):119-120.(in Chinese)徐贵，叶猛，方桂平．盱眙地区甲胎蛋白、癌胚抗原参考区间的建立[J]．实验与检验医学，2015,33(1):119-120.

[7] BJERNER J,HOGETVEIT A,WOLD AKSELBERG K,et al.Reference intervals for carcinoembryonic antigen(CEA),CA125,MUC1,Alfa-foeto-protein(AFP),neuron-specific enolase(NSE)and CA199 from the NORIP study[J].Scand J Clin Lab Invest,2008,68(8):703-713.

[8] ZHANG GM,GUO XX,MA XB,et al. Reference intervals of alpha-fetoprotein and carcinoembryonic antigen in the apparently healthy population[J]. Med Sci Monit,2016,22:4875-4880.

[9] ICHIHARA K,BOYD JC. An appraisal of statistical procedures used in derivation of reference intervals[J]. Clin Chem Lab Med,2010,48(11):1537-1551.

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