贝特类药物治疗原发性胆汁性胆管炎的研究现状

卫晶; 武希润

doi:10.3969/j.issn.1001-5256.2020.02.046

贝特类药物治疗原发性胆汁性胆管炎的研究现状

DOI: 10.3969/j.issn.1001-5256.2020.02.046

卫晶,
武希润

山西医科大学第二医院消化内科

详细信息

中图分类号: R575.7
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出版历程
- 收稿日期: 2019-09-19
- 出版日期: 2020-02-20

Current status of research on fibrates in treatment of primary biliary cholangitis

Wei Jing,
Wu XiRun

Department of Gastroenterology,The Second Hospital of Shanxi Medical University

摘要

摘要:
目前被美国食品药品监督管理局批准用于治疗原发性胆汁性胆管炎(PBC)的药物包括熊去氧胆酸和奥贝胆酸。对熊去氧胆酸应答不佳、不能耐受奥贝胆酸瘙痒副作用的患者亟需新的治疗药物。近年来大量基础实验和临床研究认为贝特类药物对PBC疗效显著。就贝特类药物治疗原发性胆汁性胆管炎的机制进展及临床应用作一综述。
- 原发性胆汁性胆管炎 /
- 纤维酸类 /
- 治疗学
Abstract:
At present,ursodeoxycholic acid( UDCA) and obeticholic acid( OCA) are approved by FDA for the treatment of primary biliary cholangitis( PBC). New drugs are urgently needed for the patients who have inadequate response to UDCA or cannot tolerate pruritus,a common side effect of OCA. In recent years,a large number of basic experiments and clinical studies have shown that fibrates have a good clinical effect in the treatment of PBC. This article reviews the advances in the mechanism and clinical application of fibrates in the treatment of PBC.
- primary biliary cholangitis /
- fibric acids /
- therapeutics

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参考文献(42)

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