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Endoplasmic reticulum stress signaling pathway and its association with liver diseases
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摘要:
内质网应激(ERS)表现为内质网腔内错误折叠与未折叠蛋白聚集以及钙离子平衡紊乱,可激活未折叠蛋白反应、内质网超负荷反应和固醇调节级联反应等信号通路,既能引发糖调节蛋白GRP78、GRP94等内质网分子伴侣表达而产生保护效应,亦能诱导细胞凋亡。目前,关于ERS参与肝脏疾病的发生发展尚无系统性认识。综述了ERS相关信号通路的新进展及与其相关的部分肝脏疾病新进展,并对ERS介导的细胞凋亡及其在肝脏疾病中的作用进行阐述。干预ERS信号通路有望为未来肝脏疾病研究及治疗提供参考。
Abstract:Endoplasmic reticulum stress( ERS) manifests as the aggregation of misfolded and unfolded proteins in the endoplasmic reticulum lumen and disorder of calcium balance and can activate the signaling pathways involved in unfolded protein response,endoplasmic reticulum overload reaction,and sterol regulatory cascade response. ERS can not only exert a protective effect by inducing the expression of endoplasmic reticulum molecular chaperones such as glucose-regulated protein 78 and glucose-regulated protein 94,but also induce cell apoptosis.At present,there is still no systematic understanding of ERS involvement in the development and progression of liver diseases. This article summarizes the research advances in ERS-related signaling pathways and related liver diseases and elaborates on the role of ERS-mediated cell apoptosis in liver diseases. The intervention of ERS signaling pathways may provide a reference for the research and treatment of liver diseases in the future.
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Key words:
- liver diseases /
- endoplasmic reticulum stress /
- signal transduction /
- apoptosis
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