STAT3:慢性炎症介导肝癌进程的关键分子

音金萍; 岳紫晨; 卓少元

doi:10.3969/j.issn.1001-5256.2020.04.054

STAT3:慢性炎症介导肝癌进程的关键分子

DOI: 10.3969/j.issn.1001-5256.2020.04.054

广西中医药大学基础医学院

基金项目:

国家自然科学基金地区科学基金项目(81660775,81860824)；

详细信息

中图分类号: R735.7
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出版历程
- 出版日期: 2020-04-20

STAT3: A key molecule in the progression of liver cancer mediated by chronic inflammation

School of Basic Medical Sciences, Guangxi University of Chinese Medicine

Research funding:

摘要

摘要: STAT3是信号转导及转录激活因子家族成员,在肝癌等慢性炎症相关性肿瘤中异常激活。作为肝癌炎症微环境中的关键信号分子,STAT3不仅参与肝癌发生过程中的"炎癌转化",而且通过多种方式促进肝癌进展中癌细胞的增殖、侵袭与转移,是一个潜在的肝癌治疗靶标。综述了近几年STAT3与肝癌关系的新进展。
- 肝肿瘤 /
- STAT3转录因子 /
- 炎症
Abstract: STAT3,a member of the signal transducer and activator of transcription family,is abnormally activated in chronic inflammation-related tumors including liver cancer. As a key signal molecule in the microenvironment of liver cancer and inflammation,STAT3 not only participates in the inflammation-cancer transformation during the development of liver cancer,but also promotes the proliferation,invasion,and metastasis of hepatoma cells through many ways,and therefore,it may be a potential target for the treatment of liver cancer. This article reviews the recent advances in the association between STAT3 and liver cancer.
- liver neoplasms /
- STAT3 transcription factor /
- inflammation

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参考文献(53)

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