肝细胞癌微血管侵犯定义和病理分级标准

何旭昶; 安文慧; 赵海泉; 沈辉; 杨婧; 莫小华

doi:10.3969/j.issn.1001-5256.2020.05.052

肝细胞癌微血管侵犯定义和病理分级标准

DOI: 10.3969/j.issn.1001-5256.2020.05.052

1. 昆明医科大学第二附属医院肝胆胰外科
2. 昆明医科大学第二附属医院消化内科

基金项目:

科技人才和平台计划项目（2019IC034）；

详细信息

中图分类号: R735.7
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出版历程
- 出版日期: 2020-05-20

Microvascular invasion in hepatocellular carcinoma:Definition and criteria for pathological grading

Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming 650000, China

Research funding:

摘要

摘要:
肝细胞癌的预后与微血管侵犯(MVI)密切相关,近年来对于MVI的临床研究越来越多,但对于基础病理发展与争议的文献则较少。作为临床研究的基础,了解微血管侵犯的定义及病理分级的争议具有重要意义。旨在对MVI定义的发展历程进行回顾,复习现有文献,并对MVI病理分级标准的研究现状进行分析,探讨不同分级标准对于肝细胞癌术后复发的预测价值,为MVI的临床研究提供参考。
- 癌,肝细胞 /
- 微血管侵犯 /
- 病理学
Abstract:
The prognosis of hepatocellular carcinoma(HCC) is closely associated microvascular invasion(MVI), and in recent years, more and more clinical studies have been conducted on MVI, but there are few articles on the development of basic pathology and related controversies. As the basis of clinical research, it is of great significance to understand the definition of MVI and the controversy over pathological grading. With reference to related articles, this article reviews the development history of the definition of MVI, analyzes the current status of the research on the criteria for pathological grading of MVI, and assesses the value of different criteria in predicting postoperative recurrence of HCC, so as to provide a reference for the clinical research on MVI.
- carcinoma,hepatocellular /
- microvascular invasion /
- pathology

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参考文献(32)

[1] BRAY F, FERLAY J, SOERJOMATARAM I, et al. Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2018, 68(6):394-424.

[2] CHEN W, ZHENG R, BAADE PD, et al. Cancer statistics in China, 2015[J]. CA Cancer J Clin 2016, 66(2):115-132.

[3] POON RT, FAN ST, TSANG FH, et al. Locoregional therapies for hepatocellular carcinoma:A critical review from the surgeon’s perspective[J]. Ann Surg, 2002, 235(4):466-486.

[4] van NAGELL JR Jr, DONALDSON ES, WOOD EG, et al. The significance of vascular invasion and lymphocytic infiltration in invasive cervical cancer[J]. Cancer, 1978, 41(1):228-234.

[5] BATSAKIS JG. Invasion of the microcirculation in head and neck cancer[J]. Ann Otol Rhinol Laryngol, 1984, 93(6 Pt1):646-647.

[6] CLOSE LG, BURNS DK, REISCH J, et al. Microvascular invasion in cancer of the oral cavity and oropharynx[J]. Arch Otolaryngol Head Neck Surg, 1987, 113(11):1191-1195.

[7] MAZZAFERRO V, REGALIA E, DOCI R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis[J]. N Engl J Med, 1996, 334(11):693-699.

[8] COSTENTIN CE, BABABEKOV YJ, ZHU AX, et al. Is it time to reconsider the Milan criteria for selecting patients with hepatocellular carcinoma for deceased-donor liver transplantation?[J]. Hepatology, 2019, 69(3):1324-1336.

[9] IWATSUKI S, DVORCHIK I, MARSH JW, et al. Liver transplantation for hepatocellular carcinoma:A proposal of a prognostic scoring system[J]. J Am Coll Surg, 2000, 191(4):389-394.

[10] ESNAOLA NF, LAUWERS GY, MIRZA NQ, et al. Predictors of microvascular invasion in patients with hepatocellular carcinoma who are candidates for orthotopic liver transplantation[J].J Gastrointest Surg, 2002, 6(2):224-232; discussion 232.

[11] SUMIE S, KUROMATSU R, OKUDA K, et al. Microvascular invasion in patients with hepatocellular carcinoma and its predictable clinicopathological factors[J]. Ann Surg Oncol,2008, 15(5):1375-1382.

[12] RODRÍGUEZ-PERÁLVAREZ M, LUONG TV, ANDREANA L,et al. A systematic review of microvascular invasion in hepatocellular carcinoma:Diagnostic and prognostic variability[J].Ann Surg Oncol, 2013, 20(1):325-339.

[13] ROAYAIE S, BLUME IN, THUNG SN, et al. A system of classifying microvascular invasion to predict outcome after resection in patients with hepatocellular carcinoma[J]. Gastroenterology, 2009, 137(3):850-855.

[14] ERSTAD DJ, TANABE KK. Prognostic and therapeutic implications of microvascular invasion in hepatocellular carcinoma[J]. Ann Surg Oncol, 2019, 26(5):1474-1493.

[15] Chinese Society of Liver Cancer, Chinese Anti-Cancer Association; Liver Cancer Study Group,Chinese Society of Hepatology, Chinese Medical Association; Chinese Society of Pathology, Chinese Anti-Cancer Association, et al. Evidencebased practice guidelines for the standardized pathological diagnosis of primary liver cancer in China(2015 update)[J]. J Clin Hepatol, 2015, 31(6):833-839.(in Chinese）中国抗癌协会肝癌专业委员会，中华医学会肝病学分会肝癌学组，中国抗癌协会病理专业委员会，等．原发性肝癌规范化病理诊断指南（2015年版）[J]．临床肝胆病杂志，2015, 31(6):833-839.

[16] National Health and Family Planning Commission of the People’s Republic of China. Diagnosis, management, and treatment of hepatocellular carcinoma[J]. J Clin Hepatol, 2017(8):1419-1431.(in Chinese）中华人民共和国国家卫生和计划生育委员会．原发性肝癌诊疗规范（2017年版）[J]．临床肝胆病杂志，2017(8):1419-1431.

[17] China Association for the Promotion of International Medical and Health Care Exchanges, Liver Cancer Branch. Expert consensus on HCC with vascular invasion(discussion draft)[J/CD]. Electronic J Liver Tumor, 2015, 2(3):8-18.(in Chinese）中国医疗保健国际交流促进会肝脏肿瘤分会．肝细胞癌合并血管侵犯专家共识（讨论稿）[J/CD]．肝癌电子杂志，2015, 2(3):8-18.

[18] WANG J, MA JL. Prognostic factors of liver cancer[J]. Chin J Gen Surg, 2015, 24(2):270-274.(in Chinese）汪晋，马金良．肝癌预后相关影响因素[J]．中国普通外科杂志，2015, 24(2):270-274.

[19] ZHANG XJ, LIU J, LIU K, et al. Effect of microvascular invasion on prognosis of patients with hepatocellular carcinoma after hepatectomy[J]. Chin J Dig Surg, 2018, 17(5):483-487.(in Chinese）张小晶，刘静，刘坤，等．微血管侵犯对肝癌肝切除术后预后的影响[J]．中华消化外科杂志，2018, 17(5):483-487.

[20] SHAH SA, TAN JC, MCGILVRAY ID, et al. Does microvascular invasion affect outcomes after liver transplantation for HCC?A histopathological analysis of 155 consecutive explants[J]. J Gastrointest Surg, 2007, 11(4):464-471.

[21] SALA M, FUSTER J, LLOVET JM, et al. High pathological risk of recurrence after surgical resection for hepatocellular carcinoma:An indica tion for salvage liver transplantation[J]. Liver Transpl, 2004, 10(10):1294-1300.

[22] YAMAMOTO Y, IKOMA H, MORIMURA R, et al. Post-hepatectomy survival in advanced hepatocellular carcinoma with portal vein tumor thrombosis[J]. World J Gastroenterol,2015, 21(1):246-253.

[23] IGUCHI T, SHIRABE K, AISHIMA S, et al. New pathologic stratification of microvascular invasion in hepatocellular carcinoma:Predicting prognosis after living-donor liver transplantation[J]. Transplantation, 2015, 99(6):1236-1242.

[24] SUMIE S, NAKASHIMA O, OKUDA K, et al. The significance of classifying microvascular invasion in patients with hepatocellular carcinoma[J]. Ann Surg Oncol, 2014, 21(3):1002-1009.

[25] ZHAO H, CHEN C, FU X, et al. Prognostic value of a novel risk classification of microvascular invasion in patients with hepatocell ular carcinoma after resection[J]. Oncotarget,2017, 8(3):5474-5486.

[26] ZHANG XJ, WANG L. Clinical significance of microvascular invasion in the comprehensive diagnosis and treatment of hepatocellular carcinoma[J]. Chin J Dig Surg, 2019, 18(4):336-341.(in Chinese）张小晶，王琳．微血管侵犯在肝癌综合诊断与治疗中的临床意义[J]．中华消化外科杂志，2019, 18(4):336-341.

[27] FENG LH, DONG H, LAU WY, et al. Novel microvascular invasion-based prognostic nomograms to predict survival outcomes in patients after R0 resection for hepatocellular carcinoma[J]. J Cancer Res Clin Oncol, 2017, 143(2):293-303.

[28] ZHANG X, LI J, SHEN F, et al. Significance of presence of microvascular invasion in specimens obtained after surgical treatment of hepatocellular carcinoma[J]. J Gastroenterol Hepatol, 2018, 33(2):347-354.

[29] ERSTAD DJ, TANABE KK. Prognostic and therapeutic implications of microvascular invasion in hepatocellular carcinoma[J]. Ann Surg Oncol, 2019, 26(5):1474-149327.

[30] CHICHE L, MENAHEM B, BAZILLE C, et al. Recurrence of hepatocellular carcinoma in noncirrhotic liver after hepatectomy[J]. World J Surg, 2013, 37(10):2410-2418.

[31] LIM C, MISE Y, SAKAMOTO Y, et al. Above 5 cm, size does not matter anymore in patients with hepatocellular carcinoma[J]. World J Surg, 2014, 38(11):2910-2918.

[32] OKUSAKA T, OKADA S, UENO H, et al. Satellite lesions in patients with small hepatocellular carcinoma with reference to clinicopathologic features[J]. Cancer, 2002, 95(9):1931-1937.

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