免疫反应与炎症损伤在肝衰竭发病机制中的作用

王挺帅; 王娜; 张荣臻; 王明刚; 黄少东; 马玉珍; 吴聪; 毛德文

doi:10.3969/j.issn.1001-5256.2020.06.050

免疫反应与炎症损伤在肝衰竭发病机制中的作用

DOI: 10.3969/j.issn.1001-5256.2020.06.050

1. 湖南中医药大学研究生学院
2. 广西中医药大学第一附属医院肝病一区
3. 广西中医药大学研究生学院

基金项目:

国家自然科学基金(81774236,81560752)；广西科技攻关项目(2018GXNSFGA281002，桂科AD17129001，桂科AA17202036，桂科攻1598011-7,2017AB45166)；广西自然科学基金(2018JJA140362,2018JJA140500)；广西区中管局(GZZC16-17)；广西高校中青年教师基础能力提升项目(KY2016YB208)；

详细信息

中图分类号: R575.3
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出版历程
- 出版日期: 2020-06-20

Role of immune response and inflammatory injury in the pathogenesis of liver failure

Research funding:

摘要

摘要:
肝衰竭是临床上常见的严重肝病症候群,该病救治难度大,病死率高,属于内科危急重症之一。肝细胞大量死亡、肝细胞死亡程度超过肝再生的能力被认为是肝衰竭发生发展的核心事件,直接损伤和免疫介导的炎症损伤是这一过程的两个主要因素。越来越多的证据表明,宿主免疫反应与炎症级联反应在肝衰竭发病机制中极为重要。综述了免疫调节(先天性和适应性)与炎症损伤(炎症诱导物、感受细胞、炎症介质)在肝衰竭过程中的作用机制,以及免疫反应/免疫细胞与炎症反应/炎症因子的交互作用,以期有助于了解肝衰竭的发病机制,为肝衰竭的诊疗、药物研发提供新思路。
- 肝功能衰竭 /
- 免疫调节 /
- 炎症
Abstract:
Liver failure is a syndrome of severe liver diseases commonly seen in clinical practice,and it has a high mortality rate and thus becomes one of the critical diseases in internal medicine. Massive hepatocyte death and the extent of hepatocyte death exceeding the liver's regenerative capacity are considered the core events in the development and progression of liver failure,and direct injury and immune-mediated inflammatory injury are the two main factors in this process. An increasing number of evidence has shown that host immune response and inflammatory cascade play an important role in the pathogenesis of liver failure. This article reviews the mechanism of action of immunoregulation( congenital and adaptive) and inflammatory injury( inflammation inducers,receptor cells,and inflammatory mediators) in the process of hepatic failure,as well as the interactions between immune response and immune cells and between inflammatory response and inflammatory factors,in order to help understand the pathogenesis of liver failure and provide new ideas for the diagnosis and treatment of liver failure and drug research and development.
- liver failure /
- immunomodulation /
- inflammatory

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参考文献(59)

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