恶性黑色素瘤肝门区转移长期存活1例报告

李书轩; 寇凯; 吕国悦

doi:10.3969/j.issn.1001-5256.2021.01.033

恶性黑色素瘤肝门区转移长期存活1例报告

DOI: 10.3969/j.issn.1001-5256.2021.01.033

吉林大学第一医院肝胆胰外科，长春 130021

基金项目:

吉林省科技厅卫生专项 (20130413021GH)

作者贡献声明：李书轩负责课题设计，资料分析，撰写论文；寇凯参与收集数据，修改论文；吕国悦负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

作者简介:
李书轩(1993—)，男，主要从事肝胆外科相关疾病的研究

通信作者:
吕国悦，lgy08@sina.com

中图分类号: R739.5;R73-37
计量
- 文章访问数: 698
- HTML全文浏览量: 479
- PDF下载量: 35
- 被引次数: 0
出版历程
- 收稿日期: 2020-07-13
- 录用日期: 2020-08-14
- 出版日期: 2021-01-20

Long-term survival of malignant melanoma with porta hepatis metastasis: A case report

Department of Hepatopancreatobiliary Surgery, The First Hospital of Jilin University, Changchun 130021, China

摘要

- 黑色素瘤 /
- 肿瘤转移 /
- 治疗学 /
- 诊断
- Melanoma /
- Neoplasm Metastasis /
- Therapeutics /
- Diagnosis

HTML全文

图 1 CT三期增强检查结果

注：a，平扫期可见肝门区异常密度影；b，动脉期肿物明显不均匀强化；c，平衡期可见强化程度稍减低。

下载: 全尺寸图片幻灯片

图 2 术后病理组织染色结果

注：a，可见瘤细胞内、细胞间质噬色素细胞含有较多黑素(HE染色，×40)；b，HMB45阳性(免疫组化，×20)；c，S-100阳性(免疫组化，×20)。

下载: 全尺寸图片幻灯片

参考文献(29)

[1]	YUNCE M, SELINGER S, KRIMSKY W, et al. Primary malignant melanoma of the lung: A case report of a rare tumor and review of the literature[J]. J Community Hosp Intern Med Perspect, 2018, 8(1): 29-31. DOI: 10.1080/20009666.2018.1424485
[2]	KOZOVSKA Z, GABRISOVA V, KUCEROVA L. Malignant melanoma: Diagnosis, treatment and cancer stem cells[J]. Neoplasma, 2016, 63(4): 510-517. DOI: 10.4149/neo_2016_403
[3]	MANOLIDIS S, DONALD PJ. Malignant mucosal melanoma of the head and neck: Review of the literature and report of 14 patients[J]. Cancer, 1997, 80(8): 1373-1386. DOI: 10.1002/(SICI)1097-0142(19971015)80:8<1373::AID-CNCR3>3.0.CO;2-G
[4]	MERIC JB, RIXE O, KHAYAT D. Metastatic malignant melanoma[J]. Drugs Today (Barc), 2003, 39(Suppl C): 17-38. http://www.ingentaconnect.com/contentone/ben/cmcaca/2003/00000003/00000006/art00002
[5]	MORAN B, SIVAL R, PERRY AS, et al. Epigenetics of malignant melanoma[J]. Semin Cancer Biol, 2018, 8(51): 80-88.
[6]	LONG J, LUO J, YIN X. miR-367 enhances the proliferation and invasion of cutaneous malignant melanoma by regulating phosphatase and tensin homolog expression[J]. Mol Med Rep, 2018, 17(5): 6526-6532. http://www.ncbi.nlm.nih.gov/pubmed/29512776
[7]	HUANG R, ROFSTAD EK. Integrins as therapeutic targets in the organ-specific metastasis of human malignant melanoma[J]. J Exp Clin Cancer Res, 2018, 37(1): 92. DOI: 10.1186/s13046-018-0763-x
[8]	THOMAS L, TRANCHAND P, BERARD F, et al. Semiological value of ABCDE criteria in the diagnosis of cutaneous pigmented tumors[J]. Dermatology, 1998, 197(1): 11-17. DOI: 10.1159/000017969
[9]	KNACKSTEDT T, KNACKSTEDT RW, COUTO R, et al. Malignant melanoma: Diagnostic and management update[J]. Plast Reconstr Surg, 2018, 142(2): 202e-216e. DOI: 10.1097/PRS.0000000000004571
[10]	BATSAKIS JG, REGEZI JA, SOLOMON AR, et al. The pathology of head and neck tumors: Mucosal melanomas, part 13[J]. Head Neck Surg, 1982, 4(5): 404-418. DOI: 10.1002/hed.2890040509
[11]	THOMPSON LD, WIENEKE JA, MIETTINEN M. Sinonasal tract and nasopharyngeal melanomas: A clinicopathologic study of 115 cases with a proposed staging system[J]. Am J Surg Pathol, 2003, 27(5): 594-611. DOI: 10.1097/00000478-200305000-00004
[12]	MARGHOOB AA, MARCHETTI M, HALPERN AC, et al. Comment on: Screening for malignant melanoma-a critical assessment in historical perspective[J]. Dermatol Pract Concept, 2018, 8(2): 73-74. DOI: 10.5826/dpc.0802a01
[13]	BEN-IZHAK O, STARK P, LEVY R, et al. Epithelial markers in malignant melanoma. A study of primary lesions and their metastases[J]. Am J Dermatopathol, 1994, 16(3): 241-246. DOI: 10.1097/00000372-199406000-00003
[14]	BUCHANAN DJ, SCHLAERTH J, KUROSAKI T. Primary vaginal melanoma: Thirteen-year disease-free survival after wide local excision and review of recent literature[J]. Am J Obstet Gynecol, 1998, 178(6): 1177-1184. DOI: 10.1016/S0002-9378(98)70320-5
[15]	LATTERI S, TEODORO M, MALAGUARNERA M, et al. Abdominal perineal resection or wilde local excision in primary anorectal malignant melanoma. Case report and review[J]. Ann Med Surg (Lond), 2017, 19: 74-77. DOI: 10.1016/j.amsu.2017.03.039
[16]	LIU J, ZHOU F, ZHANG L, et al. A case report: Nasopharyngeal malignant melanoma metastasized to gallbladder in[J]. J Clin Exp Pathol, 2015, (2): 230-231.(in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-LSBL201502044.htm 刘静, 周峰, 张柳, 等. 鼻咽恶性黑色素瘤转移至胆囊1例[J]. 临床与实验病理学杂志, 2015, (2): 230-231. https://www.cnki.com.cn/Article/CJFDTOTAL-LSBL201502044.htm
[17]	MARONE U, CARA${\rm{\tilde O}}$C, LOSITO S, et al. Laparoscopic cholecystectomy for melanoma metastatic to the gallbladder: Is it an adequate surgical procedure? Report of a case and review of the literature[J]. World J Surg Oncol, 2007, 5: 141. DOI: 10.1186/1477-7819-5-141
[18]	LIN ZC, HAN MR. A case report of metastatic malignant melanoma of the pancreas[J]. Chin J Pancreatol, 2016, 16(1): 32. (in Chinese) DOI: 10.3760/cma.j.issn.1674-1935.2016.01.009 林志川, 韩明瑞. 胰腺转移性恶性黑色素瘤一例[J]. 中华胰腺病杂志, 2016, 16(1): 32. DOI: 10.3760/cma.j.issn.1674-1935.2016.01.009
[19]	CHEN XL, GUO ZK, YANG ZH. Duodenal and pancreatic metastases of malignant melanoma: A case report[J]. Chin Gen Pract, 2013, 16(14): 1683-1684. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-QKYX201318046.htm 陈曦岚, 郭兆坤, 杨振华. 恶性黑色素瘤十二指肠及胰腺转移一例并文献复习[J]. 中国全科医学, 2013, 16(14): 1683-1684. https://www.cnki.com.cn/Article/CJFDTOTAL-QKYX201318046.htm
[20]	NIKFARJAM M, EVANS P, CHRISTOPHI C. Pancreatic resection for metastatic melanoma[J]. HPB (Oxford), 2003, 5(3): 174-179. DOI: 10.1080/13651820310015284
[21]	CHENG XJ, XU LB, GENG XP. Surgical resection of hepatic metastatic malignant melanoma: A case report[J]. J Hepatobiliary Surg, 2004, 12(6): 479. (in Chinese) DOI: 10.3969/j.issn.1006-4761.2004.06.033 程学俭, 许伦兵, 耿小平. 肝脏转移性恶性黑色素瘤手术切除1例报告[J]. 肝胆外科杂志, 2004, 12(6): 479. DOI: 10.3969/j.issn.1006-4761.2004.06.033
[22]	HUANG ZM, LI HZ, XIAO H, et al. Melanoma adrenal metastasis: Report of 3 cases and literature review[J]. Natl Med J China, 2010, 90(16): 1123-1125. (in Chinese) DOI: 10.3760/cma.j.issn.0376-2491.2010.16.013 黄钟明, 李汉忠, 肖河, 等. 恶性黑色素瘤肾上腺转移三例[J]. 中华医学杂志, 2010, 90(16): 1123-1125. DOI: 10.3760/cma.j.issn.0376-2491.2010.16.013
[23]	HAIGH PI, ESSNER R, WARDLAW JC, et al. Long-term survival after complete resection of melanoma metastatic to the adrenal gland[J]. Ann Surg Oncol, 1999, 6(7): 633-639. DOI: 10.1007/s10434-999-0633-z
[24]	MITTENDORF EA, LIM SJ, SCHACHERER CW, et al. Melanoma adrenal metastasis: Natural history and surgical management[J]. Am J Surg, 2008, 195(3): 363-368; discussion 368-369. DOI: 10.1016/j.amjsurg.2007.12.018
[25]	XIANG Y, ZHANG W, QIN XL, et al. Primary fundus malignant melanoma with gastrointestinal peritoneal metastasis a case report[J]. Shaanxi Med J, 2006, 35(11): 1568-1568. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-SXYZ200611101.htm 相祎, 张伟, 秦小玲, 等. 原发性胃底恶性黑色素瘤并消化道腹腔转移1例[J]. 陕西医学杂志, 2006, 35(11): 1568-1568. https://www.cnki.com.cn/Article/CJFDTOTAL-SXYZ200611101.htm
[26]	SONG SX, ZHOU Y, CHEN P, et al. Anorectal malignant melanoma with posterior rectal lymph node metastasis: A case report[J]. Inter Natl J Surg, 2014, 41(10): 712-713. (in Chinese) DOI: 10.3760/cma.j.issn.1673-4203.2014.10.021 宋树祥, 周宇, 陈平, 等. 肛管直肠恶性黑色素瘤伴直肠后方淋巴结转移一例[J]. 国际外科学杂志, 2014, 41(10): 712-713. DOI: 10.3760/cma.j.issn.1673-4203.2014.10.021
[27]	POPESCU A, HAIDAR A, ANGHEL RM. Treating malignant melanoma when a rare BRAF V600M mutation is present: Case report and literature review[J]. Rom J Intern Med, 2018, 56(2): 122-126.
[28]	GUO J, SI L, KONG Y, et al. Phase Ⅱ, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification[J]. J Clin Oncol, 2011, 29(21): 2904-2909. DOI: 10.1200/JCO.2010.33.9275
[29]	ATKINSON V. Recent advances in malignant melanoma[J]. Intern Med J, 2017, 47(10): 1114-1121. DOI: 10.1111/imj.13574