不同亚型Numb蛋白对肝纤维化相关信号通路的影响

许燕楠; 刘平; 慕永平

doi:10.3969/j.issn.1001-5256.2021.01.036

不同亚型Numb蛋白对肝纤维化相关信号通路的影响

DOI: 10.3969/j.issn.1001-5256.2021.01.036

上海中医药大学附属曙光医院肝病二科，上海中医药大学肝病研究所，上海 201203

基金项目:

国家自然科学基金面上项目 (81573948);

国家自然科学基金面上项目 (81874390)

作者贡献说明：许燕楠负责收集查阅文献并撰写论文；刘平负责修改论文；慕永平负责指导撰写文章并最后定稿。

详细信息

作者简介:
许燕楠（1995—），女，主要从事肝硬化的基础和临床研究

通信作者:
慕永平，ypmu8888@126.com

中图分类号: R575.2
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- 被引次数: 0
出版历程
- 收稿日期: 2020-07-28
- 录用日期: 2020-08-28
- 出版日期: 2021-01-20

Effects of different subtypes of Numb protein subtypes on liver fibrosis-related signaling pathways

Second Department of Liver Cirrhosis, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine; Institute of Liver Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

摘要

摘要: 肝纤维化是各种慢性肝病发展为肝硬化的必经之路，是一个可逆的病理状态。但如何阻抑或逆转肝纤维化的发生与发展，仍是临床需要解决的重要科学问题。Numb，一个重要的细胞命运决定子，已被发现与多种疾病的发生密切相关。在肝纤维化环境中，由于Numb基因的选择性剪切作用，翻译出不同亚型的Numb蛋白，其对不同信号通路的活化以及肝干细胞的分化具有不同的调节作用。目前关于Numb蛋白不同亚型在肝纤维化中的作用报道较少。综述了不同亚型Numb蛋白对Notch、Hedgehog、P53信号通路以及对肝干细胞的调控作用，阐释其在肝纤维化治疗中的潜在应用前景。
- 肝硬化 /
- Numb蛋白亚型 /
- 信号传导
Abstract: Liver fibrosis is the only way for various chronic liver diseases to develop into liver cirrhosis and is a reversible pathological state. However, how to prevent or reverse the development and progression of liver fibrosis is still an important scientific problem to be solved in clinical practice. As an important cell fate determinant, Numb has been shown to be closely associated with the development of many diseases. In the fibrotic environment, different subtypes of Numb protein are translated due to the selective shear action of the Numb gene, which have different regulatory effects on the activation of different signaling pathways and the differentiation of liver stem cells. At present, there are few reports on the role of Numb protein subtypes in liver fibrosis. This article reviews the regulatory effect of different Numb protein subtypes on the Notch, Hedgehog, and P53 signaling pathways and liver stem cells and elaborates on their potential application prospects in the treatment of liver fibrosis.
- Liver Cirrhosis /
- Numb Protein Isoform /
- Signal Transduction

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