饮食对非酒精性脂肪性肝病肠道微生物菌型相关菌群的影响

刘巧红; 赵瑜; 胡义扬

doi:10.3969/j.issn.1001-5256.2021.04.046

饮食对非酒精性脂肪性肝病肠道微生物菌型相关菌群的影响

DOI: 10.3969/j.issn.1001-5256.2021.04.046

刘巧红¹,
赵瑜^{1, 2, 3},
胡义扬^{1, 2, 3, ,}

1.
上海中医药大学附属曙光医院肝病研究所，上海 201203
2.
上海市中医临床重点实验室，上海 201203
3.
肝肾疾病病证教育部重点实验室，上海 201203

基金项目:

国家自然科学基金重点项目 (81830119);

上海市申康行动三年计划项目 (16CR1019A)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：刘巧红拟定写作思路并撰写论文；赵瑜指导撰写文章；胡义扬负责修改论文并最后定稿。

详细信息

作者简介:
刘巧红(1991—)，女，博士，主要从事中医内科肝病学方面的研究

通信作者:
胡义扬，yyhuliver@163.com

中图分类号: R575.5
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- 文章访问数: 583
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- 被引次数: 0
出版历程
- 收稿日期: 2020-09-25
- 录用日期: 2020-10-15
- 出版日期: 2021-04-20

Effect of diet on enterotype-related gut microbiota in nonalcoholic fatty liver disease

Qiaohong LIU¹,
Yu ZHAO^{1, 2, 3},
Yiyang HU^{1, 2, 3
, ,}

1.
Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
2.
Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai 201203, China
3.
Key Laboratory of Liver and Kidney Diseases, Ministry of Education, Shanghai 201203, China

摘要

摘要: 非酒精性脂肪性肝病(NAFLD)是一种典型的慢性肝病，与肠道微生态的失调密切相关。饮食因素可能是影响肠道细菌组成和功能的最重要的驱动因素。基于肠道微生物菌型的概念，总结了饮食对NAFLD肠道微生物菌型相关菌群的影响，包含厚壁菌门/拟杆菌门的比值、拟杆菌属、普雷沃菌属、瘤胃球菌属、变形菌门、放线菌门及其他菌。指出改善饮食进而调节肠道菌群是防治NAFLD的重要策略之一，具有良好的前景，但尚需进一步的机制和临床研究。
- 非酒精性脂肪性肝病 /
- 饮食 /
- 肠道微生物菌型 /
- 肠道菌群
Abstract: Nonalcoholic fatty liver disease (NAFLD) is a typical chronic liver disease closely associated with gut dysbiosis, and dietary factor may be the most important driving factor affecting the composition and function of intestinal bacteria. Based on the concept of enterotype, this article summarizes the effect of diet on enterotype-related gut microbiota in NAFLD, including Firmicutes/Bacteroidetes ratio, Bacteroides, Prevotella, Ruminococcus, Proteobacteria, Actinobacteria, and other bacteria. It is pointed out that improving diet to regulate gut microbiota is one of the important strategies for the prevention and treatment of NAFLD and has a good prospect, which needs further mechanism and clinical research.
- Non-alcoholic Fatty Liver Disease /
- Diet /
- Enterotype /
- Gut microbiota

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