慢性HBV感染人群血清HBsAg清除的影响因素及其临床意义
DOI: 10.3969/j.issn.1001-5256.2021.07.043
利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:段金伟、张鹏负责文献资料收集、分析和初稿写作; 张婧、曾婉嘉参与文献资料的分析、整理以及内容补充; 鲁凤民负责项目构思,指导本文写作并最后定稿。
Influencing factors for serum HBsAg clearance in people with chronic hepatitis B virus infection and its clinical significance
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摘要: HBsAg清除能够显著降低慢性乙型肝炎患者终末期肝病及肝癌的发病风险,但无论是自然转归还是抗病毒治疗,HBsAg的清除率都极低。经总结分析慢性HBV感染者HBsAg自发清除和抗病毒治疗清除的影响因素以及清除后的持久性等问题,并对核酸聚合物、免疫调节剂等新型在研药物的HBsAg清除潜力进行综述,以期为今后慢性乙型肝炎的临床治愈提供线索。Abstract: HBsAg clearance can significantly reduce the risk of end-stage liver disease and liver cancer in patients with chronic hepatitis B; however, HBsAg clearance rate is very low, either by spontaneous clearance or antiviral therapy. This article summarizes the influencing factors for spontaneous clearance of HBsAg and HBsAg clearance after antiviral therapy and the durability of HBsAg clearance. In addition, this article reviews the potential of new drugs in development, such as nucleic acid polymers and immunomodulators, in HBsAg clearance, so as to provide clues for the clinical cure of chronic hepatitis B in the future.
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Key words:
- Hepatitis B /
- Hepatitis B Surface Antigens /
- Antiviral Agents
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