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中药单体调控氧化应激抗肝纤维化的机制和价值

周志文 李姗 刘湘花 李宁宁 孙宁 禄保平

周志文, 李姗, 刘湘花, 等. 中药单体调控氧化应激抗肝纤维化的机制和价值[J]. 临床肝胆病杂志, 2021, 37(9): 2198-2202. DOI: 10.3969/j.issn.1001-5256.2021.09.039
引用本文: 周志文, 李姗, 刘湘花, 等. 中药单体调控氧化应激抗肝纤维化的机制和价值[J]. 临床肝胆病杂志, 2021, 37(9): 2198-2202. DOI: 10.3969/j.issn.1001-5256.2021.09.039
ZHOU ZW, LI S, LIU XH, et al. Research advances in monomers of Chinese herbs in treatment of liver fibrosis by regulating oxidative stress[J]. J Clin Hepatol, 2021, 37(9): 2198-2202. DOI: 10.3969/j.issn.1001-5256.2021.09.039
Citation: ZHOU ZW, LI S, LIU XH, et al. Research advances in monomers of Chinese herbs in treatment of liver fibrosis by regulating oxidative stress[J]. J Clin Hepatol, 2021, 37(9): 2198-2202. DOI: 10.3969/j.issn.1001-5256.2021.09.039

中药单体调控氧化应激抗肝纤维化的机制和价值

DOI: 10.3969/j.issn.1001-5256.2021.09.039
基金项目: 

2021年度河南省高等学校重点科研项目 21B310003

2018年度河南省科技攻关项目 182102310319

详细信息
    通讯作者:

    禄保平,lbp1921@126.com

  • 中图分类号: R575.2

Research advances in monomers of Chinese herbs in treatment of liver fibrosis by regulating oxidative stress

Funds: 

Key Scientific Research Project of Henan Province in 2021 21B310003

Key Science and Technology Research Project of Henan Province in 2018 182102310319

  • 摘要: 肝纤维化是诸多类型慢性肝病的共同病理过程,是由慢性肝损伤后细胞外基质的过度沉积所致。越来越多的证据表明,氧化应激与肝纤维化的发生发展密切相关,在多种病因所致的肝纤维化病理过程中都有氧化应激的参与。中药单体成分天然、结构明确,在近年来抗肝纤维化的研究中已经取得了显著成效。就中药单体调控氧化应激相关信号通路抗肝纤维化的研究进展进行阐述。

     

  • 图  1  ROS/RNS及其来源

    注:NOX,烟酰胺腺嘌呤二核苷酸磷酸氧化酶;iNOS,诱导型一氧化氮合酶。

    表  1  中药单体或活性成分干预氧化应激的信号通路

    单体/活性成分 靶细胞/组织/动物模型 信号通路 参考文献
    芒果苷 肝组织 TGFβ/Smad [20]
    黄芪甲苷 肝纤维化小鼠 TGFβ/Smad [21]
    夏枯草总三萜 肝纤维化大鼠 TGFβ/Smad [22]
    狗肝菜多糖 肝纤维化大鼠 MAPK [26]
    柴胡皂苷 大鼠HSC-T6细胞 MAPK [24]
    熊果酸 大鼠HSC-T6细胞 PI3K/Akt [28]
    麦芽酚 肝纤维化小鼠 PI3K/Akt [29]
    熊果酸 HSC细胞 NF-κB [34]
    红景天苷 肝纤维化小鼠及HSC-T6细胞 NF-κB [35]
    水飞蓟宾 酒精性肝纤维化大鼠 Wnt/β-catenin [36]
    沙苑子黄酮 肝纤维化小鼠 Wnt/β-catenin [37]
    下载: 导出CSV
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