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昼夜节律及其相关基因与非酒精性脂肪性肝病的关系

赵晨露 赵文霞

赵晨露, 赵文霞. 昼夜节律及其相关基因与非酒精性脂肪性肝病的关系[J]. 临床肝胆病杂志, 2021, 37(9): 2225-2230. DOI: 10.3969/j.issn.1001-5256.2021.09.045
引用本文: 赵晨露, 赵文霞. 昼夜节律及其相关基因与非酒精性脂肪性肝病的关系[J]. 临床肝胆病杂志, 2021, 37(9): 2225-2230. DOI: 10.3969/j.issn.1001-5256.2021.09.045
ZHAO CL, ZHAO WX. Association of circadian rhythm and related genes with nonalcoholic fatty liver disease[J]. J Clin Hepatol, 2021, 37(9): 2225-2230. DOI: 10.3969/j.issn.1001-5256.2021.09.045
Citation: ZHAO CL, ZHAO WX. Association of circadian rhythm and related genes with nonalcoholic fatty liver disease[J]. J Clin Hepatol, 2021, 37(9): 2225-2230. DOI: 10.3969/j.issn.1001-5256.2021.09.045

昼夜节律及其相关基因与非酒精性脂肪性肝病的关系

DOI: 10.3969/j.issn.1001-5256.2021.09.045
基金项目: 

国家自然科学基金面上项目 81473651

河南省特色骨干学科中医学学科建设项目 STG-ZYXKY-2020024

详细信息
    通讯作者:

    赵文霞, Zhao-wenxia@163.com

  • 中图分类号: R575.5

Association of circadian rhythm and related genes with nonalcoholic fatty liver disease

Funds: 

General Project of National Natural Science Foundation of China 81473651

Project of Characteristic Traditional Chinese Medicine Discipline Construction of Henan Province STG-ZYXKY-2020024

  • 摘要: 近年来昼夜节律与代谢性疾病的关系逐渐受到人们重视。大量临床研究表明, 经常熬夜、轮班的人群非酒精性脂肪性肝病的发生风险明显高于作息规律的人群。基于现有数据, 重点从脂质代谢、葡萄糖代谢、肠道菌群、氧化应激、内质网应激五个方面总结了昼夜节律基因在非酒精性脂肪性肝病中的作用机制。

     

  • 图  1  昼夜节律的分子调控机制

    表  1  不同部位昼夜节律基因BMAL1敲除或沉默对糖代谢的影响

    作者(年份) 基因敲除/沉默 部位 表型
    叶绿, 等(2020) Bmal1-沉默 胰腺 ROS、Nrf2表达增加, GSIS、CAT、GSH-Px水平升高
    叶绿, 等(2020) Bmal1-沉默 胰腺 ROS和细胞凋亡增加, Sirt1 mRNA表达减少
    Curtis AM, 等(2007) Bmal1-/- 全身 血压和心率昼夜节律改变
    Anea CB, 等(2009) Bmal1-/- 全身 胆固醇和甘油三酯升高, 血管重构受损, 血管损伤和内皮功能障碍
    Marcheva B, 等(2010) Bmal1-/- 全身 胰岛素抵抗、肥胖, 葡萄糖耐受不良, 胰岛素分泌减少
    Shi S-q, 等(2013) Bmal1-/- 全身 葡萄糖耐受不良, 胰岛素分泌减少
    Shimba S, 等(2011) Bmal1-/- 全身 游离脂肪酸、甘油三酯、胆固醇水平增高, 脂肪组织、肝脏、肌肉组织脂肪沉积
    Sadacca LA, 等(2011) Bmal1-/- 胰腺 胰岛素分泌改变
    Paschos GK, 等(2012) Bmal1-/- 脂肪组织 进食行为改变、肥胖
    Xie Z, 等(2015) Bmal1-/- 平滑肌 胰岛细胞大小和增殖受损, 血压节律丧失
    Harfmann BD, 等(2016) Bmal1-/- 骨骼肌 肌肉中的葡萄糖代谢受损和紊乱
    Chaix A, 等(2019) Bmal1-/- 肝脏 血清甘油三酯升高, 肝内脂肪沉积, 循环葡萄糖清除受损
    Lamia KA, 等(2008) Bmal1-/- 肝脏 血清甘油三酯升高, 肝内脂肪沉积, 循环葡萄糖清除受损
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