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肠道菌群在代谢相关脂肪性肝病中的作用

杨礼丹 何訸 安振梅

杨礼丹, 何訸, 安振梅. 肠道菌群在代谢相关脂肪性肝病中的作用[J]. 临床肝胆病杂志, 2021, 37(9): 2231-2235. DOI: 10.3969/j.issn.1001-5256.2021.09.046
引用本文: 杨礼丹, 何訸, 安振梅. 肠道菌群在代谢相关脂肪性肝病中的作用[J]. 临床肝胆病杂志, 2021, 37(9): 2231-2235. DOI: 10.3969/j.issn.1001-5256.2021.09.046
YANG LD, HE H, AN ZM. Role of intestinal flora in metabolic-associated fatty liver disease[J]. J Clin Hepatol, 2021, 37(9): 2231-2235. DOI: 10.3969/j.issn.1001-5256.2021.09.046
Citation: YANG LD, HE H, AN ZM. Role of intestinal flora in metabolic-associated fatty liver disease[J]. J Clin Hepatol, 2021, 37(9): 2231-2235. DOI: 10.3969/j.issn.1001-5256.2021.09.046

肠道菌群在代谢相关脂肪性肝病中的作用

DOI: 10.3969/j.issn.1001-5256.2021.09.046
基金项目: 

国家自然科学基金 32071462

四川省科技厅项目 2021YFH0167

四川省科技厅项目 2018SZ0382

详细信息
    通讯作者:

    安振梅, azmhxnfm@163.com

  • 中图分类号: R575.5

Role of intestinal flora in metabolic-associated fatty liver disease

Funds: 

National Natural Science Foundation of China 32071462

Science and Technology Department of Sichuan Province 2021YFH0167

Science and Technology Department of Sichuan Province 2018SZ0382

  • 摘要: 近年来, 越来越多的研究表明, 肠道菌群对代谢相关脂肪性肝病(MAFLD)的发生发展至关重要。总结了目前研究较多的MAFLD相关肠道菌群和代谢产物, 及其在疾病过程中可能的作用机制。相关肠道菌群和代谢产物虽然有望成为MAFLD新的非侵入性诊断标志物和治疗靶点, 但应用于临床仍需要更深入的研究。现代高通量测序技术的发展为研究提供了新的思路。整合基因、蛋白质、转录、代谢等多组学的联合分析, 可以在精准医疗体制下建立对影响MAFLD的微生物因素的全面了解, 从而为肠道菌群靶向移植治疗和肝脏代谢稳态药物研发奠定基础。

     

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  • 收稿日期:  2021-01-11
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