人体肥胖测量指标与非酒精性脂肪性肝病的相关性

童聪; 李亚年; 顾达; 赵祥安; 向晓星

doi:10.3969/j.issn.1001-5256.2021.10.044

人体肥胖测量指标与非酒精性脂肪性肝病的相关性

DOI: 10.3969/j.issn.1001-5256.2021.10.044

1.
扬州大学医学院，江苏扬州 225009
2.
大连医科大学研究生院，辽宁大连 116044
3.
江苏省苏北人民医院消化内科，江苏扬州 225001

基金项目:

江苏省自然科学基金青年项目 (SBK2020040678);

扬州市科技计划项目 (YZ2020101)

详细信息

通信作者:
向晓星，165059971@qq.com

中图分类号: R575.5
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- 文章访问数: 432
- HTML全文浏览量: 157
- PDF下载量: 56
- 被引次数: 0
出版历程
- 收稿日期: 2021-03-10
- 录用日期: 2021-04-22
- 出版日期: 2021-10-20

The association between obesity measurement indices and nonalcoholic fatty liver disease

1.
Yangzhou University School of Medicine, Yangzhou, Jiangsu 225009, China
2.
Graduate School of Dalian Medical University, Dalian, Liaoning 116044, China
3.
Department of Gastroenterology, Subei People's Hospital of Jiangsu, Yangzhou, Jiangsu 225001, China

Research funding:

Natural Science Foundation of Jiangsu Province of China (SBK2020040678);

Science and Technology Program of Yangzhou (YZ2020101)

摘要

摘要: 非酒精性脂肪性肝病是一类肝细胞脂质异常沉积的代谢异常综合征，随着生活水平的提高，非酒精性脂肪性肝病的发病率也到了令人担忧的水平。腰围、腰臀比、腰高比等多种人体肥胖测量指标已用于肥胖的评估及多种代谢性疾病的相关性研究。介绍了非酒精性脂肪性肝病与多种人体肥胖测量指数的相关性，指出人体肥胖测量指标可以应用于非酒精性脂肪性肝病的防控工作中。
- 非酒精性脂肪性肝病 /
- 体重与身体测量 /
- 危险因素
Abstract: Nonalcoholic fatty liver disease (NAFLD) is a type of metabolic disorder syndrome of abnormal lipid deposition in hepatocytes, and with the improvement of living standards, the incidence rate of NAFLD has reached a worrying level. Several anthropometric indicators, including waist circumference, waist-hip ratio, and waist-height ratio, have been used in the evaluation of obesity and the correlation study of various metabolic diseases. This article introduces the association between NAFLD and various anthropometric indicators for obesity and points out that anthropometric indicators for obesity can be used for the prevention and control of NAFLD.
- Non-Alcoholic Fatty Liver Disease /
- Body Weights and Measures /
- Risk Factors

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参考文献(37)

[1]	ESLAM M, SANYAL AJ, GEORGE J. MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease[J]. Gastroenterology, 2020, 158(7): 1999-2014. e1. DOI: 10.1053/j.gastro.2019.11.312.
[2]	MANSOUR-GHANAEI R, MANSOUR-GHANAEI F, NAGHIPOUR M, et al. The role of anthropometric indices in the prediction of non-alcoholic fatty liver disease in the PERSIAN Guilan Cohort study (PGCS)[J]. J Med Life, 2018, 11(3): 194-202. DOI: 10.25122/jml-2018-0031.
[3]	YOUNOSSI Z, TACKE F, ARRESE M, et al. Global perspectives on nonalcoholic fatty liver disease and nonalcoholic steatohepatitis[J]. Hepatology, 2019, 69(6): 2672-2682. DOI: 10.1002/hep.30251.
[4]	WU TF, LIAO XH, ZHONG BH. Epidemiology of nonalcoholic fatty liver disease in some regions of China[J]. J Clin Hepatol, 2020, 36(6): 1370-1373. DOI: 10.3969/j.issn.1001-5256.2020.06.039. 吴挺丰, 廖献花, 钟碧慧. 中国部分地区非酒精性脂肪肝病的流行情况[J]. 临床肝胆病杂志, 2020, 36(6): 1370-1373. DOI: 10.3969/j.issn.1001-5256.2020.06.039.
[5]	ALMEIDA NS, ROCHA R, COTRIM HP, et al. Anthropometric indicators of visceral adiposity as predictors of non-alcoholic fatty liver disease: A review[J]. World J Hepatol, 2018, 10(10): 695-701. DOI: 10.4254/wjh.v10.i10.695.
[6]	YOO HJ, PARK MS, LEE CH, et al. Cutoff points of abdominal obesity indices in screening for non-alcoholic fatty liver disease in Asians[J]. Liver Int, 2010, 30(8): 1189-1196. DOI: 10.1111/j.1478-3231.2010.02300.x.
[7]	ROSS R, NEELAND IJ, YAMASHITA S, et al. Waist circumference as a vital sign in clinical practice: A Consensus Statement from the IAS and ICCR Working Group on Visceral Obesity[J]. Nat Rev Endocrinol, 2020, 16(3): 177-189. DOI: 10.1038/s41574-019-0310-7.
[8]	LIU Y, REN W, YU QR, et al. Investigation and analysis of prevalence of and relationship between metabolic syndrome and nonalcoholic fatty liver disease among 1021 female medical staff[J]. Med Recapitulate, 2020, 26(16): 3298-3302. DOI: 10.3969/j.issn.1006-2084.2020.16.033. 刘亚, 任伟, 郁秋荣, 等. 1021例女性医务人员代谢综合征和非酒精性脂肪肝的患病率及两者之间关系的调查分析[J]. 医学综述, 2020, 26(16): 3298-3302. DOI: 10.3969/j.issn.1006-2084.2020.16.033.
[9]	ZHANG X, WAN Y, ZHANG S, et al. Nonalcoholic fatty liver disease prevalence in urban school-aged children and adolescents from the Yangtze River delta region: A cross-sectional study[J]. Asia Pac J Clin Nutr, 2015, 24(2): 281-288. DOI: 10.6133/apjcn.2015.24.2.13.
[10]	JU DY, CHOE YG, CHO YK, et al. The influence of waist circumference on insulin resistance and nonalcoholic fatty liver disease in apparently healthy Korean adults[J]. Clin Mol Hepatol, 2013, 19(2): 140-147. DOI: 10.3350/cmh.2013.19.2.140.
[11]	LI JQ, LEI MY, YANG YY, et al. Advances in anthropometric prediction of cardiovascular risk factors[J]. Chin Gen Pract, 2020, 23(35): 4524-4529. DOI: 10.12114/j.issn.1007-9572.2019.00.747. 李俊晴, 雷梦媛, 杨艳艳, 等. 人体测量学指标预测心血管疾病危险因素的研究进展[J]. 中国全科医学, 2020, 23(35): 4524-4529. DOI: 10.12114/j.issn.1007-9572.2019.00.747.
[12]	LIU XL. Research advances in evaluation methods and measurement indices for adult obesity[J]. Mod Med J China, 2020, 22(5): 105-108. DOI: 10.3969/j.issn.1672-9463.2020.05.032. 刘晓龙. 成人肥胖评价方法与测量指标研究进展[J]. 中国现代医药杂志, 2020, 22(5): 105-108. DOI: 10.3969/j.issn.1672-9463.2020.05.032.
[13]	YU T, CHEN L. Analysis of the early detection value of waist circumference, waist to hip ratio and waist to body ratio in community diabetic population[J]. Chin Primary Health Care, 2021, 35(1): 62-64. DOI: 10.3969/j.issn.1001-568X.2021.01.0020. 俞婷, 陈磊. 腰围、腰臀比及腰身比对社区糖尿病人群早期发现的价值分析[J]. 中国初级卫生保健, 2021, 35(1): 62-64. DOI: 10.3969/j.issn.1001-568X.2021.01.0020.
[14]	ZHANG ZQ, DENG J, HE LP, et al. Comparison of various anthropometric and body fat indices in identifying cardiometabolic disturbances in Chinese men and women[J]. PLoS One, 2013, 8(8): e70893. DOI: 10.1371/journal.pone.0070893.
[15]	ZHENG RD, CHEN ZR, CHEN JN, et al. Role of body mass index, waist-to-height and waist-to-hip ratio in prediction of nonalcoholic fatty liver disease[J]. Gastroenterol Res Pract, 2012, 2012: 362147. DOI: 10.1155/2012/362147.
[16]	MOTAMED N, RABIEE B, HEMASI GR, et al. Body roundness index and waist-to-height ratio are strongly associated with non-alcoholic fatty liver disease: A population-based study[J]. Hepat Mon, 2016, 16(9): e39575. DOI: 10.5812/hepatmon.39575.
[17]	JIANG L, CHEN XW, ZHENG RD, et al. Waist-to-hip ratio is a superior predictor for non-alcoholic simple fatty liver[J]. Chin J Hepatol, 2010, 18(11): 859-861. DOI: 10.3760/cma.j.issn.1007-3418.2010.11.017. 蒋瓅, 陈雪婉, 郑瑞丹, 等. 腰臀比为非酒精性单纯性脂肪肝最有效的预测指标[J]. 中华肝脏病杂志, 2010, 18(11): 859-861. DOI: 10.3760/cma.j.issn.1007-3418.2010.11.017.
[18]	CHON YE, KIM HJ, CHOI YB, et al. Decrease in waist-to-hip ratio reduced the development of chronic kidney disease in non-obese non-alcoholic fatty liver disease[J]. Sci Rep, 2020, 10(1): 8996. DOI: 10.1038/s41598-020-65940-y.
[19]	AI YQ. Waist-to-height ratio: An effective index for central obesity predicting cardiovascular disease risk factors[J]. Jiangxi Med J, 2018, 53(8): 796-798. DOI: 10.3969/j.issn.1006-2238.2018.8.005. 艾雅琴. 腰围身高比值: 预测心血管风险的有效肥胖指标[J]. 江西医药, 2018, 53(8): 796-798. DOI: 10.3969/j.issn.1006-2238.2018.8.005.
[20]	ASHWELL M, GUNN P, GIBSON S. Waist-to-height ratio is a better screening tool than waist circumference and BMI for adult cardiometabolic risk factors: Systematic review and meta-analysis[J]. Obes Rev, 2012, 13(3): 275-286. DOI: 10.1111/j.1467-789X.2011.00952.x.
[21]	DU CG, WU Q, SUN HJ, et al. Predictive capacity of abdominal obesity indices for the severity of non-alcoholic fatty liver disease in physical examination population[J]. Hainan Med, 2020, 31(21): 2728-2733. DOI: 10.3969/j.issn.1003-6350.2020.21.003. 杜程钢, 武强, 孙红娟, 等. 不同腹型肥胖指标对非酒精性脂肪肝严重程度预测能力的研究[J]. 海南医学, 2020, 31(21): 2728-2733. DOI: 10.3969/j.issn.1003-6350.2020.21.003.
[22]	LIN MS, LIN TH, GUO SE, et al. Waist-to-height ratio is a useful index for nonalcoholic fatty liver disease in children and adolescents: A secondary data analysis[J]. BMC Public Health, 2017, 17(1): 851. DOI: 10.1186/s12889-017-4868-5.
[23]	ÖZHAN B, ERSOY B, ÖZKOL M, et al. Waist to height ratio: A simple screening tool for nonalcoholic fatty liver disease in obese children[J]. Turk J Pediatr, 2016, 58(5): 518-523. DOI: 10.24953/turkjped.2016.05.009.
[24]	YOUNOSSI ZM. Non-alcoholic fatty liver disease-A global public health perspective[J]. J Hepatol, 2019, 70(3): 531-544. DOI: 10.1016/j.jhep.2018.10.033.
[25]	ZHANG L, LUO SC, ZHOU XM, et al. A study on association of four physical measurements indexes with non-alcoholic fatty liver disease[J]. Chin J Prevent Control Dis, 2015, 23(9): 649-652. DOI: 10.16386/j.cjpccd.issn.1004-6194.2015.09.003. 张莉, 骆善彩, 周小梅, 等. 四项体脂测量指标与非酒精性脂肪肝的关联性研究[J]. 中国慢性病预防与控制, 2015, 23(9): 649-652. DOI: 10.16386/j.cjpccd.issn.1004-6194.2015.09.003.
[26]	ZHANG Y, LI B, LIU N, et al. Evaluation of different anthropometric indicators for screening for nonalcoholic fatty liver disease in elderly individuals[J]. Int J Endocrinol, 2021, 2021: 6678755. DOI: 10.1155/2021/6678755.
[27]	KRAKAUER NY, KRAKAUER JC. A new body shape index predicts mortality hazard independently of body mass index[J]. PLoS One, 2012, 7(7): e39504. DOI: 10.1371/journal.pone.0039504.
[28]	DHANA K, KAVOUSI M, IKRAM MA, et al. Body shape index in comparison with other anthropometric measures in prediction of total and cause-specific mortality[J]. J Epidemiol Community Health, 2016, 70(1): 90-96. DOI: 10.1136/jech-2014-205257.
[29]	DENG GJ. Association between anthropometric adiposity indexes and osteoporosis among Chinese middle-and older-aged adults[D]. Beijing: Peking Union Med Coll, 2019. 邓桂娟. 中国中老年人群人体肥胖测量指标与骨质疏松相关性研究[D]. 北京: 北京协和医学院, 2019.
[30]	YE JJ, QIN Y, ZHAO L, et al. Relationship between a body shape index and newly-diagnosed type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease[J]. Clin Focus, 2021, 36(2): 144-148. DOI: 10.3969/j.issn.1004-583X.2021.02.010. 叶菁菁, 秦瑜, 赵丽, 等. 身体形态指数与新诊2型糖尿病合并非酒精性脂肪肝的关系[J]. 临床荟萃, 2021, 36(2): 144-148. DOI: 10.3969/j.issn.1004-583X.2021.02.010.
[31]	FUJITA M, SATO Y, NAGASHIMA K, et al. Predictive power of a body shape index for development of diabetes, hypertension, and dyslipidemia in Japanese adults: A retrospective cohort study[J]. PLoS One, 2015, 10(6): e0128972. DOI: 10.1371/journal.pone.0128972.
[32]	DAI H, WANG W, CHEN R, et al. Lipid accumulation product is a powerful tool to predict non-alcoholic fatty liver disease in Chinese adults[J]. Nutr Metab (Lond), 2017, 14: 49. DOI: 10.1186/s12986-017-0206-2.
[33]	AHN N, BAUMEISTER SE, AMANN U, et al. Visceral adiposity index (VAI), lipid accumulation product (LAP), and product of triglycerides and glucose (TyG) to discriminate prediabetes and diabetes[J]. Sci Rep, 2019, 9(1): 9693. DOI: 10.1038/s41598-019-46187-8.
[34]	KYROU I, PANAGIOTAKOS DB, KOULI GM, et al. Lipid accumulation product in relation to 10-year cardiovascular disease incidence in Caucasian adults: The ATTICA study[J]. Atherosclerosis, 2018, 279: 10-16. DOI: 10.1016/j.atherosclerosis.2018.10.015.
[35]	ÖZCABI B, DEMIRHAN S, AKYOL M, et al. Lipid accumulation product is a predictor of nonalcoholic fatty liver disease in childhood obesity[J]. Korean J Pediatr, 2019, 62(12): 450-455. DOI: 10.3345/kjp.2019.00248.
[36]	YOU WY, LI LM. The predictive value of lipid accumulation index for non-alcoholic fatty liver disease with metabolic syndrome[J]. Med Info, 2020, 33(18): 62-65. DOI: 10.3969/j.issn.1006-1959.2020.18.019. 游文一, 李林蔓. 脂质蓄积指数对非酒精性脂肪性肝病合并代谢综合征的预测价值[J]. 医学信息, 2020, 33(18): 62-65. DOI: 10.3969/j.issn.1006-1959.2020.18.019.
[37]	JI BL, LI R, ZHANG SH, et al. The lipid accumulation product is highly related to serum alanine aminotransferase level in male adults[J]. Nutr Res, 2012, 32(8): 581-587. DOI: 10.1016/j.nutres.2012.06.019.