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肝移植成功治疗噬血细胞综合征导致的急性肝衰竭1例报告

马景胜 武雅君 杨文涛 何佳珂 朱红飞 饶燕飞 钟林 李齐根

引用本文:
Citation:

肝移植成功治疗噬血细胞综合征导致的急性肝衰竭1例报告

DOI: 10.3969/j.issn.1001-5256.2021.12.033
基金项目: 

国家自然科学基金 (82060126);

国家自然科学基金 (82160707);

江西省卫生健康委员会普通项目 (202130436);

江西省中医药管理局一般项目 (2020A0286)

详细信息
    通信作者:

    李齐根,22432989@qq.com

  • 中图分类号: R575.3; R617

Successful liver transplantation in the treatment of acute liver failure caused by hemophagocytic syndrome: A case report

Research funding: 

National Natural Science Foundation of China (82060126);

National Natural Science Foundation of China (82160707);

General project of Jiangxi Provincial Health Commission (202130436);

General project of Jiangxi Administration of traditional Chinese medicine (2020A0286)

  • 图  1  患者骨髓涂片

    注:图中箭头所示为噬血细胞,可见细胞吞噬RBC、粒细胞及PLT(瑞氏染色,×1000)。

    表  1  治疗过程中主要化验指标结果

    时间点 TBil
    (μmol/L)
    ALT
    (U/L)
    AST
    (U/L)
    PT
    (s)
    INR WBC
    (×109/L)
    Hb
    (g/L)
    PLT
    (×109/L)
    术前 749 83 125 45.9 3.94 2.87 93 98
    第4天 94 74 32 12.2 1.05 7.57 88 54
    第5天 150 86 72 14.9 1.29 6.42 86 38
    第7天 284 2025 4560 22.2 1.93 5.39 81 16
    第10天 271 651 432 14.7 1.28 4.31 68 24
    第14天 197 43 107 11.1 0.97 11.91 75 125
    第28天 41 38 42 11.8 1.04 8.23 96 103
    下载: 导出CSV
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    罗利婷, 张霞, 马鹤铭, 等. 以肝衰竭为主要表现的噬血细胞综合征1例报告[J]. 临床肝胆病杂志, 2020, 36(2): 412-413. DOI: 10.3969/j.issn.1001-5256.2020.02.038.
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    [12] AMMANN S, LEHMBERG K, ZUR STADT U, et al. Primary and secondary hemophagocytic lymphohistiocytosis have different patterns of T-cell activation, differentiation and repertoire[J]. Eur J Immunol, 2017, 47(2): 364-373. DOI: 10.1002/eji.201646686.
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    [14] KOU JT, LIU Z, ZHU JQ, et al. Research on clinical efficacy of liver transplantation for severe liver disease[J]. Organ Transpl, 2020, 11(4): 482-486. DOI: 10.3969/j.issn.1674-7445.2020.04.010.

    寇建涛, 刘喆, 朱继巧, 等. 肝移植治疗危重症肝病的临床疗效研究[J]. 器官移植, 2020, 11(4): 482-486. DOI: 10.3969/j.issn.1674-7445.2020.04.010.
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    傅斌生, 易述红, 易慧敏, 等. 肝移植术后噬血细胞综合征临床分析[J]. 器官移植, 2013, 4(2): 68-74. DOI: 10.3969/j.issn.1674-7445.2013.02.002.
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    [17] JANKA GE. Familial and acquired hemophagocytic lymphohistiocytosis[J]. Annu Rev Med, 2012, 63: 233-246. DOI: 10.1146/annurev-med-041610-134208.
    [18] MATTHES-MARTIN S, PETERS C, FRITSCH G, et al. Successful stem cell transplantation following orthotopic liver transplantation from the same haploidentical family donor in a girl with hemophagocytic lymphohistiocytosis[J]. Blood, 2000, 96(12): 3997-3999. DOI:10.1182/ blood.V96.12.3997.
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出版历程
  • 收稿日期:  2021-08-08
  • 录用日期:  2021-08-30
  • 出版日期:  2021-12-20
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