自身免疫性肝炎发病机制进展与临床干预新靶点

胡明礼; 王绮夏; 马雄

doi:10.3969/j.issn.1001-5256.2022.04.002

自身免疫性肝炎发病机制进展与临床干预新靶点

DOI: 10.3969/j.issn.1001-5256.2022.04.002

上海交通大学医学院附属仁济医院消化内科，上海市消化疾病研究所，上海 200001

基金项目:

国家自然科学基金 (82130017);

国家自然科学基金 (82070581);

国家自然科学基金 (81790634);

上海市卫生计生系统优秀青年医学人才培养计划 (2017YQ037);

上海市青年科技启明星计划 (18QA1402700)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：胡明礼负责查找文献、分析资料、撰写文稿；马雄和王绮夏负责确定写作思路、指导文章撰写及最后定稿。

详细信息

通信作者:
王绮夏，wqx0221155@126.com

马雄，maxiongmd@163.com

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- 被引次数: 0
出版历程
- 收稿日期: 2021-11-30
- 录用日期: 2022-01-13
- 出版日期: 2022-04-20

Advances in the pathogenesis of autoimmune hepatitis and new targets for clinical intervention

Mingli HU,
Qixia WANG^{,
,},
Xiong MA^{,
,}

Shanghai Institute of Digestive Disease, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China

Research funding:

National Natural Science Foundation of China (82130017);

National Natural Science Foundation of China (82070581);

National Natural Science Foundation of China (81790634);

The Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai (2017YQ037);

Shanghai Rising-Star Program (18QA1402700)

More Information

Corresponding author: WANG Qixia, wqx0221155@126.com(ORCID: 0000-0002-8300-6314); MA Xiong, maxiongmd@163.com(ORCID: 0000-0001-9616-4672)

摘要

摘要: 自身免疫性肝炎(AIH)是一种以肝细胞受损为主的免疫介导性肝病，以高免疫球蛋白G血症及自身抗体阳性为特征，组织学可见汇管区大量淋巴-浆细胞浸润所致的界面性肝炎。AIH发病机制尚未完全阐明，目前主要以糖皮质激素联合硫唑嘌呤进行非特异性免疫抑制治疗，多数患者应答良好。但在药物减量过程中以及停药后容易出现反跳或复发，故而大多数患者需长期维持治疗。本文就AIH发病机制进展及临床干预的潜在新靶点进行简要综述，以期为临床转化研究提供参考。
- 肝炎, 自身免疫性 /
- 病理过程 /
- 治疗学 /
- 靶点
Abstract: Autoimmune hepatitis (AIH) is an immune-mediated liver disease with hepatocytes as the main target cells. It is characterized by the high immunoglobulin G level and the presence of autoantibodies, and histological observation shows interface hepatitis at the portal area caused by a large amount of lymphoplasmacytic infiltration. The pathogenesis of AIH has not been fully elucidated. At present, glucocorticoid combined with azathioprine is mainly used as non-specific immunosuppressive therapy, and most patients tend to have good response; however, rebound or relapse is often observed during dose reduction or after drug withdrawal, so most patients need long-term maintenance therapy. This article briefly reviews the advances in the pathogenesis of AIH and the potential new targets for clinical intervention, in order to provide a reference for clinical translational research.
- Hepatitis, Autoimmune /
- Pathologic Processes /
- Therapeutics /
- Targets

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