基础慢性肝脏疾病对接受免疫检查点抑制剂治疗的肿瘤患者的疗效及安全性的影响

刘丹; 姚甜甜; 张宇涵; 王贵强; 王艳

doi:10.3969/j.issn.1001-5256.2022.11.005

基础慢性肝脏疾病对接受免疫检查点抑制剂治疗的肿瘤患者的疗效及安全性的影响

DOI: 10.3969/j.issn.1001-5256.2022.11.005

北京大学第一医院感染疾病科，北京 100034

基金项目:

国家十三五重大课题 (2017ZX10203202-002-012);

国家十三五重大课题 (2018ZX10302206-001-007);

国家自然科学基金 (81870417);

国家自然科学基金 (82070605)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：刘丹、姚甜甜、张宇涵负责查找文献，分析资料；刘丹、姚甜甜负责撰写和修改文稿；王贵强负责文章思路指导；王艳负责确定写作思路，指导文章撰写及最终定稿。

详细信息

通信作者:
王艳，wangyanwang@bjmu.edu.cn

作者说明：刘丹和姚甜甜对本文贡献等同，为共同第一作者

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出版历程
- 收稿日期: 2022-06-19
- 录用日期: 2022-07-25
- 出版日期: 2022-11-20

Efficiency and safety of immune checkpoint inhibitors in cancer patients with chronic liver disease: A systematic review

Department of Infectious Diseases, Peking University First Hospital, Beijing 100034, China

Research funding:

The Sub-Subject of the Major Projects of National Science and Technology (2017ZX10203202-002-012);

The Sub-Subject of the Major Projects of National Science and Technology (2018ZX10302206-001-007);

National Natural Science Foundation of China (81870417);

National Natural Science Foundation of China (82070605)

More Information

Corresponding author: WANG Yan, wangyanwang@bjmu.edu.cn(ORCID: 0000-0002-8577-0527)

摘要

摘要: 近年来免疫检查点抑制剂(ICI)已经被批准用于多种恶性肿瘤的治疗，与此同时，接受ICI治疗且具有慢性肝脏疾病背景的肿瘤人群大幅增加。慢性肝脏疾病是否影响ICI的疗效和安全性逐渐成为热点问题。本文简要概述合并不同类型慢性肝脏疾病(慢性病毒性肝炎、非酒精性脂肪性肝病、自身免疫性肝病、肝硬化等)基础的肿瘤(原发性肝癌、非小细胞肺癌、黑色素瘤)患者应用ICI的有效性和安全性，并对慢性乙型肝炎患者ICI治疗后HBV再激活的相关文献进行综述，以期对存在慢性肝脏疾病基础的肿瘤患者ICI使用诊疗规范的制订和完善提供依据。
- 肝疾病 /
- 肿瘤 /
- 免疫检查点抑制剂 /
- 乙型肝炎
Abstract: Immune checkpoint inhibitors (ICIs) have recently been approved for the treatment of cancer, and the number of cancer patients with chronic liver disease (CLD) receiving ICIs is growing rapidly. However, whether CLD affects the efficiency and safety of ICIs is becoming a research focus. This review summarizes the efficiency and safety of ICIs in cancer patients with CLD, including chronic viral hepatitis, non-alcoholic fatty liver disease, autoimmune liver disease, and cirrhosis. Specifically, data on hepatitis B virus reactivation of patients with chronic hepatitis B after ICIs treatment were reviewed, which may help to perfect and standardize the guidelines of treatment and following-up for ICIs in CLD patients.
- Liver Diseases /
- Neoplasms /
- Immune Checkpoint Inhibitors /
- Hepatitis B

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参考文献(39)

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