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吲哚菁绿荧光显影在困难胆囊腹腔镜胆囊切除术中的应用价值

冯其柱 王思雨 张超

引用本文:
Citation:

吲哚菁绿荧光显影在困难胆囊腹腔镜胆囊切除术中的应用价值

DOI: 10.3969/j.issn.1001-5256.2022.11.019
基金项目: 

安徽高校自然科学研究基金资助重点项目 KJ2021A0439

伦理学声明:本研究方案于2021年9月7日经由安徽医科大学第一附属医院医学伦理委员会批准, 批号:2021-15-15,所有患者均签署知情同意书。
利益冲突声明:本研究不存在研究者、伦理委员会成员、受试者监护人以及与公开研究成果有关的利益冲突。
作者贡献声明:冯其柱负责课题设计,资料分析,撰写和修改文章;王思雨参与数据收集分析;张超负责拟定写作思路,指导撰写文章。
详细信息
    通信作者:

    张超,zhangchaolove88@163.com

Application value of indocyanine green fluorescence imaging in laparoscopic cholecystectomy of difficult gallbladder

Research funding: 

Natural Science Foundation of Anhui Universities KJ2021A0439

More Information
  • 摘要:   目的  探讨吲哚菁绿(ICG)荧光显影在困难胆囊腹腔镜胆囊切除术(LC)中的应用价值。  方法  回顾性分析安徽医科大学第一附属医院2021年10月—12月行LC的患者临床资料,根据术中是否使用ICG荧光显影和是否为困难胆囊分为4组:A组为使用ICG荧光显影普通胆囊,B组为使用ICG荧光显影困难胆囊,C组为未使用ICG荧光显影普通胆囊,D组为未使用ICG荧光显影困难胆囊。比较各组手术时间、术中出血、住院时间、住院费用和术后并发症间的差异。正态分布的计量资料2组间比较采用t检验。计数资料2组间比较用χ2检验或Fisher确切概率法。  结果  A组与C组相比手术时间、术中出血、住院时间、住院费用和术中并发症,差异均无统计学意义(P值均>0.05)。B组手术时间和术中出血分别为(75.41±12.96)min和(18.27±6.97)mL,D组分别为(106.78±19.21)min和(23.99±8.43)mL,两组相比差异均有统计学意义(P值均<0.05);B组住院时间、住院费用和术后并发症与D组相比,差异均无统计学意义(P值均>0.05)。  结论  普通胆囊患者LC术中使用ICG荧光显影优势不明显;但在困难胆囊中,ICG荧光显影有利于胆道显露,可以缩短手术时间,减少术中出血。ZHANG Chao

     

  • 图  1  A组白光模式肝外胆管显露清晰

    Figure  1.  White light mode showed clear extrahepatic bile duct in group A

    图  2  C组荧光模式肝外胆管染色

    Figure  2.  Fluorescent mode extrahepatic bile duct staining in group C

    图  3  B组白光模式肝外胆管解剖不清

    Figure  3.  The anatomy of extrahepatic bile duct in group B with white light was unclear

    图  4  B组荧光模式肝外胆管显影

    Figure  4.  Fluorescent-mode extrahepatic bile duct development in group B

    表  1  患者一般资料比较

    Table  1.   Comparison of general data of patients

    组别 例数 性别(例) 年龄(岁) 合并症
    (例)
    A组 49 18 31 55.29±12.66 13
    B组 44 19 25 48.59±14.88 10
    C组 45 10 35 52.98±12.76 8
    D组 37 16 21 50.95±13.62 10
    下载: 导出CSV

    表  2  A、C组患者手术相关指标比较

    Table  2.   Comparison of surgical indicators in group A and C

    组别 例数 手术时间(min) 住院时间(d) 术中出血(mL) 住院费用(元)
    A组 49 47.16±9.79 2.51±1.00 9.63±2.60 10 163.70±1 040.61
    C组 45 49.24±9.45 2.58±1.37 9.49±2.90 9 901.79±1 044.43
    t 1.047 0.274 0.253 1.218
    P 0.298 0.785 0.801 0.226
    下载: 导出CSV

    表  3  B、D组患者手术相关指标比较

    Table  3.   Comparison of surgical indicators in group B and D

    组别 例数 手术时间(min) 住院时间(d) 术中出血(mL) 住院费用(元) 三孔法/四孔法(例)
    B组 44 75.41±12.96 2.82±1.24 18.27±6.97 10 124.12±915.56 30/14
    D组 37 106.78±19.21 3.27±1.73 23.99±8.43 10 578.99±1 404.03 15/22
    统计值 t=8.729 t=1.366 t=3.300 t=1.691 χ2=6.219
    P <0.001 0.176 0.001 0.096 0.013
    下载: 导出CSV
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  • 收稿日期:  2022-04-04
  • 录用日期:  2022-05-21
  • 出版日期:  2022-11-20
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